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Anti-alpha-fodrin antibodies in Sjögren's syndrome in children.
J Rheumatol. 2001 Apr; 28(4):860-4.JR

Abstract

OBJECTIVE

To investigate the prevalence of anti-alpha-fodrin antibody specific for adult Sjögren's syndrome (SS) in patients with juvenile onset SS.

METHODS

Serum anti-alpha-fodrin antibody was examined in 15 patients with juvenile SS (11 cases of primary SS and 4 secondary SS) and in 16 children with systemic lupus erythematosus (SLE) by Western blot analysis using a recombinant 120 kDa alpha-fodrin fusion protein.

RESULTS

All the 15 serum samples from patients with SS reacted with a recombinant alpha-fodrin fusion protein in Western blot analysis. In contrast, reactivity was found in only 2 of the 16 patients with SLE. The clinical features of the 15 patients with juvenile onset SS were very specific; only 4 patients complained of dryness, while 6 had abnormal excretion ability. Salivary gland enlargement was the most common clinical manifestation. Characteristic laboratory findings in juvenile onset SS included a higher prevalence of antinuclear antibodies, anti-SSA/Ro antibodies, and rheumatoid factor, as well as increased erythrocyte sedimentation rate and hypergammaglobulinemia.

CONCLUSION

The pathogenesis of juvenile SS seems to be the same as that of adult SS, although subjective symptoms of dryness are less frequent in juvenile cases. This discrepancy may indicate that SS is a slowly progressive disease with a long time span. The anti-alpha-fodrin antibody is likely to be a reliable diagnostic marker for juvenile SS.

Authors+Show Affiliations

Department of Pediatrics, Faculty of Medicine, Kagoshima University, Kagoshima City, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11327263

Citation

Maeno, N, et al. "Anti-alpha-fodrin Antibodies in Sjögren's Syndrome in Children." The Journal of Rheumatology, vol. 28, no. 4, 2001, pp. 860-4.
Maeno N, Takei S, Imanaka H, et al. Anti-alpha-fodrin antibodies in Sjögren's syndrome in children. J Rheumatol. 2001;28(4):860-4.
Maeno, N., Takei, S., Imanaka, H., Oda, H., Yanagi, K., Hayashi, Y., & Miyata, K. (2001). Anti-alpha-fodrin antibodies in Sjögren's syndrome in children. The Journal of Rheumatology, 28(4), 860-4.
Maeno N, et al. Anti-alpha-fodrin Antibodies in Sjögren's Syndrome in Children. J Rheumatol. 2001;28(4):860-4. PubMed PMID: 11327263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-alpha-fodrin antibodies in Sjögren's syndrome in children. AU - Maeno,N, AU - Takei,S, AU - Imanaka,H, AU - Oda,H, AU - Yanagi,K, AU - Hayashi,Y, AU - Miyata,K, PY - 2001/5/1/pubmed PY - 2001/8/10/medline PY - 2001/5/1/entrez SP - 860 EP - 4 JF - The Journal of rheumatology JO - J Rheumatol VL - 28 IS - 4 N2 - OBJECTIVE: To investigate the prevalence of anti-alpha-fodrin antibody specific for adult Sjögren's syndrome (SS) in patients with juvenile onset SS. METHODS: Serum anti-alpha-fodrin antibody was examined in 15 patients with juvenile SS (11 cases of primary SS and 4 secondary SS) and in 16 children with systemic lupus erythematosus (SLE) by Western blot analysis using a recombinant 120 kDa alpha-fodrin fusion protein. RESULTS: All the 15 serum samples from patients with SS reacted with a recombinant alpha-fodrin fusion protein in Western blot analysis. In contrast, reactivity was found in only 2 of the 16 patients with SLE. The clinical features of the 15 patients with juvenile onset SS were very specific; only 4 patients complained of dryness, while 6 had abnormal excretion ability. Salivary gland enlargement was the most common clinical manifestation. Characteristic laboratory findings in juvenile onset SS included a higher prevalence of antinuclear antibodies, anti-SSA/Ro antibodies, and rheumatoid factor, as well as increased erythrocyte sedimentation rate and hypergammaglobulinemia. CONCLUSION: The pathogenesis of juvenile SS seems to be the same as that of adult SS, although subjective symptoms of dryness are less frequent in juvenile cases. This discrepancy may indicate that SS is a slowly progressive disease with a long time span. The anti-alpha-fodrin antibody is likely to be a reliable diagnostic marker for juvenile SS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/11327263/Anti_alpha_fodrin_antibodies_in_Sjögren's_syndrome_in_children_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=11327263 DB - PRIME DP - Unbound Medicine ER -