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Copper-dependent oxidative stress and neurodegeneration.

Abstract

Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper-mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged.

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  • Authors+Show Affiliations

    ,

    Dept. of Biology, University of Rome Tor Vergata, Italy. Rotilio@bio.uniroma2.it

    , ,

    Source

    IUBMB life 50:4-5 pg 309-14

    MeSH

    Alzheimer Disease
    Amyotrophic Lateral Sclerosis
    Animals
    Apoptosis
    Copper
    Hepatolenticular Degeneration
    Humans
    Menkes Kinky Hair Syndrome
    Models, Neurological
    Nerve Degeneration
    Neurodegenerative Diseases
    Oxidative Stress
    Prion Diseases
    Superoxide Dismutase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    11327325

    Citation

    Rotilio, G, et al. "Copper-dependent Oxidative Stress and Neurodegeneration." IUBMB Life, vol. 50, no. 4-5, 2000, pp. 309-14.
    Rotilio G, Carrì MT, Rossi L, et al. Copper-dependent oxidative stress and neurodegeneration. IUBMB Life. 2000;50(4-5):309-14.
    Rotilio, G., Carrì, M. T., Rossi, L., & Ciriolo, M. R. (2000). Copper-dependent oxidative stress and neurodegeneration. IUBMB Life, 50(4-5), pp. 309-14.
    Rotilio G, et al. Copper-dependent Oxidative Stress and Neurodegeneration. IUBMB Life. 2000;50(4-5):309-14. PubMed PMID: 11327325.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Copper-dependent oxidative stress and neurodegeneration. AU - Rotilio,G, AU - Carrì,M T, AU - Rossi,L, AU - Ciriolo,M R, PY - 2001/5/1/pubmed PY - 2001/8/17/medline PY - 2001/5/1/entrez SP - 309 EP - 14 JF - IUBMB life JO - IUBMB Life VL - 50 IS - 4-5 N2 - Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper-mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged. SN - 1521-6543 UR - https://www.unboundmedicine.com/medline/citation/11327325/Copper_dependent_oxidative_stress_and_neurodegeneration_ L2 - https://doi.org/10.1080/713803724 DB - PRIME DP - Unbound Medicine ER -