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Copper-dependent oxidative stress and neurodegeneration.
IUBMB Life. 2000 Oct-Nov; 50(4-5):309-14.IL

Abstract

Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper-mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged.

Authors+Show Affiliations

Dept. of Biology, University of Rome Tor Vergata, Italy. Rotilio@bio.uniroma2.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11327325

Citation

Rotilio, G, et al. "Copper-dependent Oxidative Stress and Neurodegeneration." IUBMB Life, vol. 50, no. 4-5, 2000, pp. 309-14.
Rotilio G, Carrì MT, Rossi L, et al. Copper-dependent oxidative stress and neurodegeneration. IUBMB Life. 2000;50(4-5):309-14.
Rotilio, G., Carrì, M. T., Rossi, L., & Ciriolo, M. R. (2000). Copper-dependent oxidative stress and neurodegeneration. IUBMB Life, 50(4-5), 309-14.
Rotilio G, et al. Copper-dependent Oxidative Stress and Neurodegeneration. IUBMB Life. 2000 Oct-Nov;50(4-5):309-14. PubMed PMID: 11327325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper-dependent oxidative stress and neurodegeneration. AU - Rotilio,G, AU - Carrì,M T, AU - Rossi,L, AU - Ciriolo,M R, PY - 2001/5/1/pubmed PY - 2001/8/17/medline PY - 2001/5/1/entrez SP - 309 EP - 14 JF - IUBMB life JO - IUBMB Life VL - 50 IS - 4-5 N2 - Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper-mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged. SN - 1521-6543 UR - https://www.unboundmedicine.com/medline/citation/11327325/Copper_dependent_oxidative_stress_and_neurodegeneration_ L2 - https://doi.org/10.1080/713803724 DB - PRIME DP - Unbound Medicine ER -