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Conditioned nutritional deficiencies in the cardiomyopathic hamster heart.
Can J Cardiol. 2001 Apr; 17(4):449-58.CJ

Abstract

BACKGROUND

Evidence indicates that nutritional factors may be important in the maintenance of myocyte structure and energetics. The failing myocardium has been reported to exhibit a depletion of several nutrients that are important for the maintenance of intracellular calcium homeostasis and cellular energetics, and levels of oxidative stress. This nutrient depletion may contribute to the progressive deterioration in myocardial structure and function observed in heart failure.

OBJECTIVE

To examine the extent to which advanced cardiomyopathy results in a depletion of nutrients and/or metabolites and antioxidants, and whether supplementation with these nutrients may influence cellular structure or function.

SUBJECTS AND METHODS

Cardiomyopathic hamsters were randomly placed to one of the three following diet groups: chow; control gelled diet; or a supplemented gelled diet that provided taurine, carnitine, coenzyme Q10, selenium, vitamins E and C, creatine, thiamine and L-cysteine. After approximately three months of supplementation, one group of hamsters underwent functional testing using a modified Langendorff technique with biopsy samples taken for electron microscopy. Myocardial nutrient concentrations were determined in a second group of diseased and nondiseased hamsters of the same age.

RESULTS

Cardiomyopathy resulted in a depletion of vitamin E, creatine, carnitine, taurine and coenzyme Q10. Supplementation resulted in improved cardiac ultrastructure, function and contractility compared with nonsupplemented hamsters.

CONCLUSIONS

These studies suggest that heart failure results in 'condition-related nutrient deficiencies' that, once corrected, can significantly impact on heart function and structure.

Authors+Show Affiliations

The University Health Network, Toronto General Hospital, Toronto, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11329545

Citation

Keith, M E., et al. "Conditioned Nutritional Deficiencies in the Cardiomyopathic Hamster Heart." The Canadian Journal of Cardiology, vol. 17, no. 4, 2001, pp. 449-58.
Keith ME, Ball A, Jeejeebhoy KN, et al. Conditioned nutritional deficiencies in the cardiomyopathic hamster heart. Can J Cardiol. 2001;17(4):449-58.
Keith, M. E., Ball, A., Jeejeebhoy, K. N., Kurian, R., Butany, J., Dawood, F., Wen, W. H., Madapallimattam, A., & Sole, M. J. (2001). Conditioned nutritional deficiencies in the cardiomyopathic hamster heart. The Canadian Journal of Cardiology, 17(4), 449-58.
Keith ME, et al. Conditioned Nutritional Deficiencies in the Cardiomyopathic Hamster Heart. Can J Cardiol. 2001;17(4):449-58. PubMed PMID: 11329545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conditioned nutritional deficiencies in the cardiomyopathic hamster heart. AU - Keith,M E, AU - Ball,A, AU - Jeejeebhoy,K N, AU - Kurian,R, AU - Butany,J, AU - Dawood,F, AU - Wen,W H, AU - Madapallimattam,A, AU - Sole,M J, PY - 2001/5/1/pubmed PY - 2001/6/8/medline PY - 2001/5/1/entrez SP - 449 EP - 58 JF - The Canadian journal of cardiology JO - Can J Cardiol VL - 17 IS - 4 N2 - BACKGROUND: Evidence indicates that nutritional factors may be important in the maintenance of myocyte structure and energetics. The failing myocardium has been reported to exhibit a depletion of several nutrients that are important for the maintenance of intracellular calcium homeostasis and cellular energetics, and levels of oxidative stress. This nutrient depletion may contribute to the progressive deterioration in myocardial structure and function observed in heart failure. OBJECTIVE: To examine the extent to which advanced cardiomyopathy results in a depletion of nutrients and/or metabolites and antioxidants, and whether supplementation with these nutrients may influence cellular structure or function. SUBJECTS AND METHODS: Cardiomyopathic hamsters were randomly placed to one of the three following diet groups: chow; control gelled diet; or a supplemented gelled diet that provided taurine, carnitine, coenzyme Q10, selenium, vitamins E and C, creatine, thiamine and L-cysteine. After approximately three months of supplementation, one group of hamsters underwent functional testing using a modified Langendorff technique with biopsy samples taken for electron microscopy. Myocardial nutrient concentrations were determined in a second group of diseased and nondiseased hamsters of the same age. RESULTS: Cardiomyopathy resulted in a depletion of vitamin E, creatine, carnitine, taurine and coenzyme Q10. Supplementation resulted in improved cardiac ultrastructure, function and contractility compared with nonsupplemented hamsters. CONCLUSIONS: These studies suggest that heart failure results in 'condition-related nutrient deficiencies' that, once corrected, can significantly impact on heart function and structure. SN - 0828-282X UR - https://www.unboundmedicine.com/medline/citation/11329545/Conditioned_nutritional_deficiencies_in_the_cardiomyopathic_hamster_heart_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:11329545 DB - PRIME DP - Unbound Medicine ER -