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Growth hormone together with glutamine-containing total parenteral nutrition maintains muscle glutamine levels and results in a less negative nitrogen balance after surgical trauma.
Surgery. 2001 May; 129(5):576-86.S

Abstract

BACKGROUND

Muscle protein catabolism, reflected by a decrease in glutamine (GLN), a decrease in muscle protein synthesis, and a negative nitrogen balance can be reduced by either administration of GLN or growth hormone (GH). In this study, the effects of a combination of GH and GLH were studied.

METHODS

Patients (n = 16) undergoing abdominal operation were given total parenteral nutrition (TPN) containing either GLN alone or GLN together with GH (GH/GLN) during 3 postoperative days. The amino acid concentration and protein synthesis in muscle tissue and the nitrogen balance were measured.

RESULTS

GH/GLN reduced nitrogen losses compared with GLN alone (-5.8 +/- 1.4 g nitrogen versus -10.6 +/- 1.1 g nitrogen, P <.05). GH/GLN maintained muscle GLN at preoperative levels compared with a 47.5% +/- 6.3% decline in the GLN group. A similar decrease was seen in the fractional synthesis rate of muscle protein postoperatively in both groups.

CONCLUSIONS

GH has an additive effect given together with GLN on muscle amino acid metabolism, preventing the decrease in the GLN concentration in skeletal muscle and diminishing the loss of whole body nitrogen. However, the improvements in muscle amino acid concentrations and nitrogen loss were not associated with differences between the groups in muscle protein synthesis postoperatively.

Authors+Show Affiliations

Gastrocentrum, Huddinge University Hospital, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11331450

Citation

Hammarqvist, F, et al. "Growth Hormone Together With Glutamine-containing Total Parenteral Nutrition Maintains Muscle Glutamine Levels and Results in a Less Negative Nitrogen Balance After Surgical Trauma." Surgery, vol. 129, no. 5, 2001, pp. 576-86.
Hammarqvist F, Sandgren A, Andersson K, et al. Growth hormone together with glutamine-containing total parenteral nutrition maintains muscle glutamine levels and results in a less negative nitrogen balance after surgical trauma. Surgery. 2001;129(5):576-86.
Hammarqvist, F., Sandgren, A., Andersson, K., Essén, P., McNurlan, M. A., Garlick, P. J., & Wernerman, J. (2001). Growth hormone together with glutamine-containing total parenteral nutrition maintains muscle glutamine levels and results in a less negative nitrogen balance after surgical trauma. Surgery, 129(5), 576-86.
Hammarqvist F, et al. Growth Hormone Together With Glutamine-containing Total Parenteral Nutrition Maintains Muscle Glutamine Levels and Results in a Less Negative Nitrogen Balance After Surgical Trauma. Surgery. 2001;129(5):576-86. PubMed PMID: 11331450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth hormone together with glutamine-containing total parenteral nutrition maintains muscle glutamine levels and results in a less negative nitrogen balance after surgical trauma. AU - Hammarqvist,F, AU - Sandgren,A, AU - Andersson,K, AU - Essén,P, AU - McNurlan,M A, AU - Garlick,P J, AU - Wernerman,J, PY - 2001/5/2/pubmed PY - 2001/6/2/medline PY - 2001/5/2/entrez SP - 576 EP - 86 JF - Surgery JO - Surgery VL - 129 IS - 5 N2 - BACKGROUND: Muscle protein catabolism, reflected by a decrease in glutamine (GLN), a decrease in muscle protein synthesis, and a negative nitrogen balance can be reduced by either administration of GLN or growth hormone (GH). In this study, the effects of a combination of GH and GLH were studied. METHODS: Patients (n = 16) undergoing abdominal operation were given total parenteral nutrition (TPN) containing either GLN alone or GLN together with GH (GH/GLN) during 3 postoperative days. The amino acid concentration and protein synthesis in muscle tissue and the nitrogen balance were measured. RESULTS: GH/GLN reduced nitrogen losses compared with GLN alone (-5.8 +/- 1.4 g nitrogen versus -10.6 +/- 1.1 g nitrogen, P <.05). GH/GLN maintained muscle GLN at preoperative levels compared with a 47.5% +/- 6.3% decline in the GLN group. A similar decrease was seen in the fractional synthesis rate of muscle protein postoperatively in both groups. CONCLUSIONS: GH has an additive effect given together with GLN on muscle amino acid metabolism, preventing the decrease in the GLN concentration in skeletal muscle and diminishing the loss of whole body nitrogen. However, the improvements in muscle amino acid concentrations and nitrogen loss were not associated with differences between the groups in muscle protein synthesis postoperatively. SN - 0039-6060 UR - https://www.unboundmedicine.com/medline/citation/11331450/Growth_hormone_together_with_glutamine_containing_total_parenteral_nutrition_maintains_muscle_glutamine_levels_and_results_in_a_less_negative_nitrogen_balance_after_surgical_trauma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6060(01)99750-8 DB - PRIME DP - Unbound Medicine ER -