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Age and gender differences in basal and isoprenaline protocols for head-up tilt table testing.
Europace. 2001 Apr; 3(2):136-40.E

Abstract

AIMS

Syncope is a common occurrence, the prevalence of which increases with age, and among the multiple causes of syncope, neurally mediated syncope is thought to be a frequent cause in the young and in the elderly. Head-up tilt table testing (HUT) has become the diagnostic test of choice for neurally mediated syncope, the response to which varies clearly with age. The purpose of this study is to report the differences among patients suffering syncope referred for HUT, and the influence of age and gender on HUT results (percentage of positive responses and response patterns) in two study protocols (basal and isoprenaline).

METHODS AND RESULTS

One thousand, two hundred and nineteen patients with syncope were referred to the authors' Cardiology Department for HUT from September 1990 to April 2000; 1061 undergoing basal HUT (Group A) and 158 undergoing isoprenaline tilt table testing (Group B). Complications were noted in neither protocol. Females were more frequent among young people, and males in the elderly (P<0.05). Head-up tilt table testing was abnormal in 259 (24.4%) patients in Group A and in 85 (53.7%) patients in Group B (P<0.05), and no gender differences were observed. The positive rate of tests in men and women significantly declined with age in Group A (P<0.05), but not in Group B (P=ns). There were no differences in the patterns of haemodynamic collapse in both groups.

CONCLUSIONS

In the study of syncope, basal HUT has a high positive rate in young people; a decrease in positive rate with age suggests, however, the need for using another protocol with a similar diagnostic accuracy in the elderly.

Authors+Show Affiliations

Barón-Esquivias G
Cardiology Department, Hospital Universitario Virgen del Rocío, Seville, Spain. gbaron@jet.es
Pedrote A
No affiliation info available
Cayuela A
No affiliation info available
Valle JI
No affiliation info available
Fernández JM
No affiliation info available
Estepa MJ
No affiliation info available
Martínez-Morentín E
No affiliation info available
Navarro M
No affiliation info available
Burgos J
No affiliation info available

MeSH

AdultAge FactorsDose-Response Relationship, DrugFemaleHumansIsoproterenolMaleMiddle AgedReference ValuesSex FactorsSyncopeSyncope, VasovagalTilt-Table Test

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11333051

Citation

Barón-Esquivias, G, et al. "Age and Gender Differences in Basal and Isoprenaline Protocols for Head-up Tilt Table Testing." Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 3, no. 2, 2001, pp. 136-40.
Barón-Esquivias G, Pedrote A, Cayuela A, et al. Age and gender differences in basal and isoprenaline protocols for head-up tilt table testing. Europace. 2001;3(2):136-40.
Barón-Esquivias, G., Pedrote, A., Cayuela, A., Valle, J. I., Fernández, J. M., Estepa, M. J., Martínez-Morentín, E., Navarro, M., & Burgos, J. (2001). Age and gender differences in basal and isoprenaline protocols for head-up tilt table testing. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 3(2), 136-40.
Barón-Esquivias G, et al. Age and Gender Differences in Basal and Isoprenaline Protocols for Head-up Tilt Table Testing. Europace. 2001;3(2):136-40. PubMed PMID: 11333051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age and gender differences in basal and isoprenaline protocols for head-up tilt table testing. AU - Barón-Esquivias,G, AU - Pedrote,A, AU - Cayuela,A, AU - Valle,J I, AU - Fernández,J M, AU - Estepa,M J, AU - Martínez-Morentín,E, AU - Navarro,M, AU - Burgos,J, PY - 2001/5/3/pubmed PY - 2001/9/8/medline PY - 2001/5/3/entrez SP - 136 EP - 40 JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology JO - Europace VL - 3 IS - 2 N2 - AIMS: Syncope is a common occurrence, the prevalence of which increases with age, and among the multiple causes of syncope, neurally mediated syncope is thought to be a frequent cause in the young and in the elderly. Head-up tilt table testing (HUT) has become the diagnostic test of choice for neurally mediated syncope, the response to which varies clearly with age. The purpose of this study is to report the differences among patients suffering syncope referred for HUT, and the influence of age and gender on HUT results (percentage of positive responses and response patterns) in two study protocols (basal and isoprenaline). METHODS AND RESULTS: One thousand, two hundred and nineteen patients with syncope were referred to the authors' Cardiology Department for HUT from September 1990 to April 2000; 1061 undergoing basal HUT (Group A) and 158 undergoing isoprenaline tilt table testing (Group B). Complications were noted in neither protocol. Females were more frequent among young people, and males in the elderly (P<0.05). Head-up tilt table testing was abnormal in 259 (24.4%) patients in Group A and in 85 (53.7%) patients in Group B (P<0.05), and no gender differences were observed. The positive rate of tests in men and women significantly declined with age in Group A (P<0.05), but not in Group B (P=ns). There were no differences in the patterns of haemodynamic collapse in both groups. CONCLUSIONS: In the study of syncope, basal HUT has a high positive rate in young people; a decrease in positive rate with age suggests, however, the need for using another protocol with a similar diagnostic accuracy in the elderly. SN - 1099-5129 UR - https://www.unboundmedicine.com/medline/citation/11333051/Age_and_gender_differences_in_basal_and_isoprenaline_protocols_for_head_up_tilt_table_testing_ DB - PRIME DP - Unbound Medicine ER -