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Vertical transmission of HIV from mother to child in sub-Saharan Africa: modes of transmission and methods for prevention.
Obstet Gynecol Surv 2001; 56(5):306-12OG

Abstract

The impact of the human immunodeficiency virus (HIV) epidemic in sub-Saharan Africa on future mortality rates of infants, children, and mothers, life expectancy, and economic growth is profound. Vertical transmission of HIV, transmission from mother to child, is a major factor in the increasing rates of HIV infection in sub-Saharan Africa. Vertical transmission of HIV occurs in utero, intrapartum during labor and delivery, and postpartum during breast-feeding. Because of the large numbers of HIV-infected mothers in developing countries, the majority trials regarding prevention of vertical transmission of HIV have been conducted in sub-Saharan Africa. Thus, sub-Saharan Africa has become a human laboratory, which demonstrates both the successes and failures of preventative methods to reduce vertical transmission of HIV. This review summarizes the body of research dedicated to understanding the pathophysiology of vertical transmission of HIV and pharmacology of inhibition of vertical transmission of HIV. While many debate the ethics of conducting trials in developing countries where effective prevention modalities have been slow to be implemented for economic, social and political reasons, studies continue and researchers continue to discover therapies and preventative methods, which may reduce the future devastation of HIV both in sub-Saharan Africa and throughout the world.

Authors+Show Affiliations

West Virginia University School of Medicine, Morgantown, USA. santimyi@hotmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11333377

Citation

Santmyire, B R.. "Vertical Transmission of HIV From Mother to Child in sub-Saharan Africa: Modes of Transmission and Methods for Prevention." Obstetrical & Gynecological Survey, vol. 56, no. 5, 2001, pp. 306-12.
Santmyire BR. Vertical transmission of HIV from mother to child in sub-Saharan Africa: modes of transmission and methods for prevention. Obstet Gynecol Surv. 2001;56(5):306-12.
Santmyire, B. R. (2001). Vertical transmission of HIV from mother to child in sub-Saharan Africa: modes of transmission and methods for prevention. Obstetrical & Gynecological Survey, 56(5), pp. 306-12.
Santmyire BR. Vertical Transmission of HIV From Mother to Child in sub-Saharan Africa: Modes of Transmission and Methods for Prevention. Obstet Gynecol Surv. 2001;56(5):306-12. PubMed PMID: 11333377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vertical transmission of HIV from mother to child in sub-Saharan Africa: modes of transmission and methods for prevention. A1 - Santmyire,B R, PY - 2001/5/3/pubmed PY - 2001/7/13/medline PY - 2001/5/3/entrez SP - 306 EP - 12 JF - Obstetrical & gynecological survey JO - Obstet Gynecol Surv VL - 56 IS - 5 N2 - The impact of the human immunodeficiency virus (HIV) epidemic in sub-Saharan Africa on future mortality rates of infants, children, and mothers, life expectancy, and economic growth is profound. Vertical transmission of HIV, transmission from mother to child, is a major factor in the increasing rates of HIV infection in sub-Saharan Africa. Vertical transmission of HIV occurs in utero, intrapartum during labor and delivery, and postpartum during breast-feeding. Because of the large numbers of HIV-infected mothers in developing countries, the majority trials regarding prevention of vertical transmission of HIV have been conducted in sub-Saharan Africa. Thus, sub-Saharan Africa has become a human laboratory, which demonstrates both the successes and failures of preventative methods to reduce vertical transmission of HIV. This review summarizes the body of research dedicated to understanding the pathophysiology of vertical transmission of HIV and pharmacology of inhibition of vertical transmission of HIV. While many debate the ethics of conducting trials in developing countries where effective prevention modalities have been slow to be implemented for economic, social and political reasons, studies continue and researchers continue to discover therapies and preventative methods, which may reduce the future devastation of HIV both in sub-Saharan Africa and throughout the world. SN - 0029-7828 UR - https://www.unboundmedicine.com/medline/citation/11333377/Vertical_transmission_of_HIV_from_mother_to_child_in_sub_Saharan_Africa:_modes_of_transmission_and_methods_for_prevention_ L2 - http://RD3FS2PT9J.search.serialssolutions.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqm&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&issn=0029-7828&eissn=1533-9866&volume=56&issue=5&spage=306&date=2001 DB - PRIME DP - Unbound Medicine ER -