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Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.

Abstract

BACKGROUND

Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida.

CASE

A 34-year-old primigravida had congenital combined deficiency of factors II, VII, IX, and X that were incompletely sensitive to vitamin K. She had an altered form of vitamin K-dependent factors that retained immunologic activity but lacked coagulant activity and the normal complement of gamma-carboxyglutamic acid residues. She required vitamin K supplementation throughout her life. After an uneventful pregnancy she had postpartum hemorrhage resulting from an episiotomy. Fresh frozen plasma was administered to achieve hemostasis. The remainder of her postpartum course was normal.

CONCLUSION

Combined congenital deficiency of factors II, VII, IX, and X can be managed in pregnancy with the use of vitamin K and fresh frozen plasma.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 214 MacNider Building, CB #7516, Chapel Hill, NC 27599-7516, USA. mcmahon@med.unc.edu

    Source

    Obstetrics and gynecology 97:5 Pt 2 2001 May pg 808-9

    MeSH

    Adult
    Blood Transfusion
    Coagulation Protein Disorders
    Factor VII Deficiency
    Factor X Deficiency
    Female
    Hemophilia B
    Humans
    Hypoprothrombinemias
    Plasma
    Postnatal Care
    Pregnancy
    Pregnancy Complications
    Prenatal Care

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    11336760

    Citation

    McMahon, M J., and A H. James. "Combined Deficiency of Factors II, VII, IX, and X (Borgschulte-Grigsby Deficiency) in Pregnancy." Obstetrics and Gynecology, vol. 97, no. 5 Pt 2, 2001, pp. 808-9.
    McMahon MJ, James AH. Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. Obstet Gynecol. 2001;97(5 Pt 2):808-9.
    McMahon, M. J., & James, A. H. (2001). Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. Obstetrics and Gynecology, 97(5 Pt 2), pp. 808-9.
    McMahon MJ, James AH. Combined Deficiency of Factors II, VII, IX, and X (Borgschulte-Grigsby Deficiency) in Pregnancy. Obstet Gynecol. 2001;97(5 Pt 2):808-9. PubMed PMID: 11336760.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. AU - McMahon,M J, AU - James,A H, PY - 2001/5/5/pubmed PY - 2001/5/26/medline PY - 2001/5/5/entrez SP - 808 EP - 9 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 97 IS - 5 Pt 2 N2 - BACKGROUND: Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida. CASE: A 34-year-old primigravida had congenital combined deficiency of factors II, VII, IX, and X that were incompletely sensitive to vitamin K. She had an altered form of vitamin K-dependent factors that retained immunologic activity but lacked coagulant activity and the normal complement of gamma-carboxyglutamic acid residues. She required vitamin K supplementation throughout her life. After an uneventful pregnancy she had postpartum hemorrhage resulting from an episiotomy. Fresh frozen plasma was administered to achieve hemostasis. The remainder of her postpartum course was normal. CONCLUSION: Combined congenital deficiency of factors II, VII, IX, and X can be managed in pregnancy with the use of vitamin K and fresh frozen plasma. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/11336760/Combined_deficiency_of_factors_II_VII_IX_and_X__Borgschulte_Grigsby_deficiency__in_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S002978440001214X DB - PRIME DP - Unbound Medicine ER -