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Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy.
Obstet Gynecol 2001; 97(5 Pt 2):808-9OG

Abstract

BACKGROUND

Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida.

CASE

A 34-year-old primigravida had congenital combined deficiency of factors II, VII, IX, and X that were incompletely sensitive to vitamin K. She had an altered form of vitamin K-dependent factors that retained immunologic activity but lacked coagulant activity and the normal complement of gamma-carboxyglutamic acid residues. She required vitamin K supplementation throughout her life. After an uneventful pregnancy she had postpartum hemorrhage resulting from an episiotomy. Fresh frozen plasma was administered to achieve hemostasis. The remainder of her postpartum course was normal.

CONCLUSION

Combined congenital deficiency of factors II, VII, IX, and X can be managed in pregnancy with the use of vitamin K and fresh frozen plasma.

Authors+Show Affiliations

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 214 MacNider Building, CB #7516, Chapel Hill, NC 27599-7516, USA. mcmahon@med.unc.eduNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11336760

Citation

McMahon, M J., and A H. James. "Combined Deficiency of Factors II, VII, IX, and X (Borgschulte-Grigsby Deficiency) in Pregnancy." Obstetrics and Gynecology, vol. 97, no. 5 Pt 2, 2001, pp. 808-9.
McMahon MJ, James AH. Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. Obstet Gynecol. 2001;97(5 Pt 2):808-9.
McMahon, M. J., & James, A. H. (2001). Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. Obstetrics and Gynecology, 97(5 Pt 2), pp. 808-9.
McMahon MJ, James AH. Combined Deficiency of Factors II, VII, IX, and X (Borgschulte-Grigsby Deficiency) in Pregnancy. Obstet Gynecol. 2001;97(5 Pt 2):808-9. PubMed PMID: 11336760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. AU - McMahon,M J, AU - James,A H, PY - 2001/5/5/pubmed PY - 2001/5/26/medline PY - 2001/5/5/entrez SP - 808 EP - 9 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 97 IS - 5 Pt 2 N2 - BACKGROUND: Combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) is an uncommon challenge for the expectant gravida. CASE: A 34-year-old primigravida had congenital combined deficiency of factors II, VII, IX, and X that were incompletely sensitive to vitamin K. She had an altered form of vitamin K-dependent factors that retained immunologic activity but lacked coagulant activity and the normal complement of gamma-carboxyglutamic acid residues. She required vitamin K supplementation throughout her life. After an uneventful pregnancy she had postpartum hemorrhage resulting from an episiotomy. Fresh frozen plasma was administered to achieve hemostasis. The remainder of her postpartum course was normal. CONCLUSION: Combined congenital deficiency of factors II, VII, IX, and X can be managed in pregnancy with the use of vitamin K and fresh frozen plasma. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/11336760/Combined_deficiency_of_factors_II_VII_IX_and_X__Borgschulte_Grigsby_deficiency__in_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S002978440001214X DB - PRIME DP - Unbound Medicine ER -