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Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay.
Nutr Cancer 2000; 38(1):23-9NC

Abstract

In 1998-1999, a case-control study on esophageal cancer was conducted in Uruguay. For this purpose, 111 cases with squamous cell carcinoma of the esophagus and 444 controls with conditions unrelated to tobacco smoking, alcohol drinking, or recent changes in the diet were frequency matched on age, gender, residence, and urban/rural status. Vegetables and, more markedly, fruits were associated with strong reductions in risk. On the other hand, 12 of 15 dietary antioxidants displayed significant inverse associations with esophageal cancer risk. The strongest effect was observed for high intake of beta-cryptoxanthin (odds ratio = 0.16, 95% confidence interval = 0.08-0.36). Also, alpha-carotene, lycopene, and beta-sitosterol were associated with significant reductions in risk. Most antioxidants lost their effect when they were further adjusted for a term for all vegetables and fruits. beta-Carotene showed an increased risk with high intakes. On the other hand, vegetables and fruits remained as significant variables after adjustment for each antioxidant, suggesting that other substances or other mechanisms could explain this effect.

Authors+Show Affiliations

Registro Nacional de Cáncer, Montevideo, Uruguay.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11341040

Citation

De Stefani, E, et al. "Vegetables, Fruits, Related Dietary Antioxidants, and Risk of Squamous Cell Carcinoma of the Esophagus: a Case-control Study in Uruguay." Nutrition and Cancer, vol. 38, no. 1, 2000, pp. 23-9.
De Stefani E, Brennan P, Boffetta P, et al. Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutr Cancer. 2000;38(1):23-9.
De Stefani, E., Brennan, P., Boffetta, P., Ronco, A. L., Mendilaharsu, M., & Deneo-Pellegrini, H. (2000). Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutrition and Cancer, 38(1), pp. 23-9.
De Stefani E, et al. Vegetables, Fruits, Related Dietary Antioxidants, and Risk of Squamous Cell Carcinoma of the Esophagus: a Case-control Study in Uruguay. Nutr Cancer. 2000;38(1):23-9. PubMed PMID: 11341040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. AU - De Stefani,E, AU - Brennan,P, AU - Boffetta,P, AU - Ronco,A L, AU - Mendilaharsu,M, AU - Deneo-Pellegrini,H, PY - 2001/5/9/pubmed PY - 2002/1/25/medline PY - 2001/5/9/entrez SP - 23 EP - 9 JF - Nutrition and cancer JO - Nutr Cancer VL - 38 IS - 1 N2 - In 1998-1999, a case-control study on esophageal cancer was conducted in Uruguay. For this purpose, 111 cases with squamous cell carcinoma of the esophagus and 444 controls with conditions unrelated to tobacco smoking, alcohol drinking, or recent changes in the diet were frequency matched on age, gender, residence, and urban/rural status. Vegetables and, more markedly, fruits were associated with strong reductions in risk. On the other hand, 12 of 15 dietary antioxidants displayed significant inverse associations with esophageal cancer risk. The strongest effect was observed for high intake of beta-cryptoxanthin (odds ratio = 0.16, 95% confidence interval = 0.08-0.36). Also, alpha-carotene, lycopene, and beta-sitosterol were associated with significant reductions in risk. Most antioxidants lost their effect when they were further adjusted for a term for all vegetables and fruits. beta-Carotene showed an increased risk with high intakes. On the other hand, vegetables and fruits remained as significant variables after adjustment for each antioxidant, suggesting that other substances or other mechanisms could explain this effect. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/11341040/Vegetables_fruits_related_dietary_antioxidants_and_risk_of_squamous_cell_carcinoma_of_the_esophagus:_a_case_control_study_in_Uruguay_ L2 - http://www.tandfonline.com/doi/full/10.1207/S15327914NC381_4 DB - PRIME DP - Unbound Medicine ER -