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Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats.

Abstract

Processed meat intake is associated with increased risk of colorectal cancer. This association may be explained by the endogenous formation of N-nitroso compounds (NOC). The hypothesis that meat intake can increase fecal NOC levels and colon carcinogenesis was tested in 175 Fischer 344 rats. Initiation was assessed by the number of aberrant crypt foci (ACF) in the colon of rats 45 days after the start of a high-fat bacon-based diet. Promotion was assessed by the multiplicity of ACF (crypts per ACF) in rats given experimental diets for 100 days starting 7 days after an azoxymethane injection. Three promotion studies were done, each in 5 groups of 10 rats, whose diets contained 7%, 14%, or 28% fat. Tested meats were bacon, pork, chicken, and beef. Fecal and dietary NOC were assayed by thermal energy analysis. Results show that feces from rats fed bacon-based diets contained 10-20 times more NOC than feces from control rats fed a casein-based diet (all p < 0.0001 in 4 studies). In bacon-fed rats, the amount of NOC input (diet) and output (feces) was similar. Rats fed a diet based on beef, pork, or chicken meat had less fecal NOC than controls (most p < 0.01). No ACF were detected in the colon of bacon-fed uninitiated rats. After azoxymethane injection, unprocessed but cooked meat-based diets did not change the number of ACF or the ACF multiplicity compared with control rats. In contrast, the bacon-based diet consistently reduced the number of large ACF per rat and the ACF multiplicity in the three promotion studies by 12%, 17%, and 20% (all p < 0.01). Results suggest that NOC from dietary bacon would not enhance colon carcinogenesis in rats.

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  • Authors+Show Affiliations

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    Laboratoire Sécurité des Aliments, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire, 31076 Toulouse, France.

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    Source

    Nutrition and cancer 38:1 2000 pg 74-80

    MeSH

    Animals
    Azoxymethane
    Carcinogens
    Cattle
    Chickens
    Colonic Neoplasms
    Dietary Fats
    Disease Models, Animal
    Feces
    Female
    Food Handling
    Meat
    Nitroso Compounds
    Random Allocation
    Rats
    Rats, Inbred F344
    Risk Factors
    Swine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11341048

    Citation

    Parnaud, G, et al. "Endogenous N-nitroso Compounds, and Their Precursors, Present in Bacon, Do Not Initiate or Promote Aberrant Crypt Foci in the Colon of Rats." Nutrition and Cancer, vol. 38, no. 1, 2000, pp. 74-80.
    Parnaud G, Pignatelli B, Peiffer G, et al. Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats. Nutr Cancer. 2000;38(1):74-80.
    Parnaud, G., Pignatelli, B., Peiffer, G., Taché, S., & Corpet, D. E. (2000). Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats. Nutrition and Cancer, 38(1), pp. 74-80.
    Parnaud G, et al. Endogenous N-nitroso Compounds, and Their Precursors, Present in Bacon, Do Not Initiate or Promote Aberrant Crypt Foci in the Colon of Rats. Nutr Cancer. 2000;38(1):74-80. PubMed PMID: 11341048.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats. AU - Parnaud,G, AU - Pignatelli,B, AU - Peiffer,G, AU - Taché,S, AU - Corpet,D E, PY - 2001/5/9/pubmed PY - 2002/1/25/medline PY - 2001/5/9/entrez SP - 74 EP - 80 JF - Nutrition and cancer JO - Nutr Cancer VL - 38 IS - 1 N2 - Processed meat intake is associated with increased risk of colorectal cancer. This association may be explained by the endogenous formation of N-nitroso compounds (NOC). The hypothesis that meat intake can increase fecal NOC levels and colon carcinogenesis was tested in 175 Fischer 344 rats. Initiation was assessed by the number of aberrant crypt foci (ACF) in the colon of rats 45 days after the start of a high-fat bacon-based diet. Promotion was assessed by the multiplicity of ACF (crypts per ACF) in rats given experimental diets for 100 days starting 7 days after an azoxymethane injection. Three promotion studies were done, each in 5 groups of 10 rats, whose diets contained 7%, 14%, or 28% fat. Tested meats were bacon, pork, chicken, and beef. Fecal and dietary NOC were assayed by thermal energy analysis. Results show that feces from rats fed bacon-based diets contained 10-20 times more NOC than feces from control rats fed a casein-based diet (all p < 0.0001 in 4 studies). In bacon-fed rats, the amount of NOC input (diet) and output (feces) was similar. Rats fed a diet based on beef, pork, or chicken meat had less fecal NOC than controls (most p < 0.01). No ACF were detected in the colon of bacon-fed uninitiated rats. After azoxymethane injection, unprocessed but cooked meat-based diets did not change the number of ACF or the ACF multiplicity compared with control rats. In contrast, the bacon-based diet consistently reduced the number of large ACF per rat and the ACF multiplicity in the three promotion studies by 12%, 17%, and 20% (all p < 0.01). Results suggest that NOC from dietary bacon would not enhance colon carcinogenesis in rats. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/11341048/Endogenous_N_nitroso_compounds_and_their_precursors_present_in_bacon_do_not_initiate_or_promote_aberrant_crypt_foci_in_the_colon_of_rats_ L2 - http://www.tandfonline.com/doi/full/10.1207/S15327914NC381_11 DB - PRIME DP - Unbound Medicine ER -