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Reticulocyte subpopulations and reticulocyte maturity index (RMI) rise as body iron status falls.
Am J Hematol. 2001 Jun; 67(2):130-5.AJ

Abstract

To investigate the influence of body iron status on reticulocyte subpopulations and reticulocyte maturity index (RMI), we measured serum iron markers, fluorescent intensity of reticulocytes, and serum transferrin receptor (sTfR) concentrations in 374 females aged 14-19 years. Reticulocyte subpopulations were analyzed by flow cytometry, and sTfR concentration was measured by enzyme immunoassay. There were no significant differences in the values of reticulocyte subpopulations and RMI between ferritin alone-depleted group and healthy controls. However, middle- and high-fluorescence reticulocytes and RMI were significantly higher in both the serum iron- and serum ferritin-depleted groups than in the ferritin alone-depleted group. Middle-fluorescence reticulocytes and RMI increased gradually as the body iron store was depleted and were 3.4- and 3.6-fold higher, respectively, than normal controls, when the subjects attained a frank iron-deficiency anemia. There were no significant changes in the values of red blood cells or total reticulocyte counts during iron-depleted states. The mean value of sTfR (3.98 mg/l) in the subjects with RMI > or = 1.5% was significantly higher than that (2.26 mg/l) in the subjects with RMI < 1.5% (P < 0.01). The sTfR concentration correlated significantly with RMI (r = 0.61, P < 0.01) and middle-fluorescence reticulocytes (r = 0.59, P < 0.01). In short, body iron depletion induces elevation of immature reticulocyte fractions and RMI.

Authors+Show Affiliations

Department of Clinical Pathology, College of Medicine, Inha University, Inha University Hospital, Inchon, Korea. jwchoi@inha.ac.krNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11343386

Citation

Choi, J W., and S H. Pai. "Reticulocyte Subpopulations and Reticulocyte Maturity Index (RMI) Rise as Body Iron Status Falls." American Journal of Hematology, vol. 67, no. 2, 2001, pp. 130-5.
Choi JW, Pai SH. Reticulocyte subpopulations and reticulocyte maturity index (RMI) rise as body iron status falls. Am J Hematol. 2001;67(2):130-5.
Choi, J. W., & Pai, S. H. (2001). Reticulocyte subpopulations and reticulocyte maturity index (RMI) rise as body iron status falls. American Journal of Hematology, 67(2), 130-5.
Choi JW, Pai SH. Reticulocyte Subpopulations and Reticulocyte Maturity Index (RMI) Rise as Body Iron Status Falls. Am J Hematol. 2001;67(2):130-5. PubMed PMID: 11343386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reticulocyte subpopulations and reticulocyte maturity index (RMI) rise as body iron status falls. AU - Choi,J W, AU - Pai,S H, PY - 2001/5/9/pubmed PY - 2001/6/22/medline PY - 2001/5/9/entrez SP - 130 EP - 5 JF - American journal of hematology JO - Am J Hematol VL - 67 IS - 2 N2 - To investigate the influence of body iron status on reticulocyte subpopulations and reticulocyte maturity index (RMI), we measured serum iron markers, fluorescent intensity of reticulocytes, and serum transferrin receptor (sTfR) concentrations in 374 females aged 14-19 years. Reticulocyte subpopulations were analyzed by flow cytometry, and sTfR concentration was measured by enzyme immunoassay. There were no significant differences in the values of reticulocyte subpopulations and RMI between ferritin alone-depleted group and healthy controls. However, middle- and high-fluorescence reticulocytes and RMI were significantly higher in both the serum iron- and serum ferritin-depleted groups than in the ferritin alone-depleted group. Middle-fluorescence reticulocytes and RMI increased gradually as the body iron store was depleted and were 3.4- and 3.6-fold higher, respectively, than normal controls, when the subjects attained a frank iron-deficiency anemia. There were no significant changes in the values of red blood cells or total reticulocyte counts during iron-depleted states. The mean value of sTfR (3.98 mg/l) in the subjects with RMI > or = 1.5% was significantly higher than that (2.26 mg/l) in the subjects with RMI < 1.5% (P < 0.01). The sTfR concentration correlated significantly with RMI (r = 0.61, P < 0.01) and middle-fluorescence reticulocytes (r = 0.59, P < 0.01). In short, body iron depletion induces elevation of immature reticulocyte fractions and RMI. SN - 0361-8609 UR - https://www.unboundmedicine.com/medline/citation/11343386/Reticulocyte_subpopulations_and_reticulocyte_maturity_index__RMI__rise_as_body_iron_status_falls_ L2 - https://doi.org/10.1002/ajh.1091 DB - PRIME DP - Unbound Medicine ER -