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Relation between plasma leptin and anthropometric and metabolic covariates in lean and obese diabetic and hyperlipidaemic Asian Northern Indian subjects.
Diabetes Nutr Metab. 2001 Feb; 14(1):18-26.DN

Abstract

This study investigated the relationship of plasma leptin to obesity, diabetes and hyperlipidaemia in Asian Northern Indian subjects, considered to have a predisposition to abdominal obesity and metabolic syndrome. A total of 72 subjects, subcategorised into lean and obese healthy subjects, lean and obese Type 2 diabetic and lean and obese non-diabetic hyperlipidaemic subjects were recruited. High leptin values were observed in all obese groups, and obese diabetic patients showed the highest levels. In lean and obese diabetic subjects, plasma leptin did not show any correlation to any index of glycaemia. When all lean and all obese subjects were analysed in two separate groups, body mass index (BMI), percent total body fat, and body density significantly correlated with the plasma leptin levels (p<0.05). Leptin values, when correlated to all variables in all patients taken together, showed the greatest magnitude of correlation with BMI (r=0.64), percent total body fat (r=0.67), and waist circumference (r=0.51). Strong inverse correlation was seen with body density (r=-0.67). Levels of serum insulin did not show any correlation with leptin levels in all subjects combined, and separately in various groups. Multiple linear regression analysis performed in obese, non-diabetic and normolipidaemic subjects, all Type 2 diabetic and all non-diabetic hyperlipidaemic subjects separately showed that percent total body fat is the only significant predictor of plasma leptin concentration in all the 3 groups. The present study suggests that plasma leptin has a strong positive correlation with percent total body fat in Asian Northern Indian subjects. Among other components of metabolic syndrome, only abdominal obesity is weakly correlated to serum leptin levels.

Authors+Show Affiliations

Department of Medicine, All India Institute of Medical Sciences, New Delhi. anoopmisra@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11345162

Citation

Misra, A, et al. "Relation Between Plasma Leptin and Anthropometric and Metabolic Covariates in Lean and Obese Diabetic and Hyperlipidaemic Asian Northern Indian Subjects." Diabetes, Nutrition & Metabolism, vol. 14, no. 1, 2001, pp. 18-26.
Misra A, Arora N, Mondal S, et al. Relation between plasma leptin and anthropometric and metabolic covariates in lean and obese diabetic and hyperlipidaemic Asian Northern Indian subjects. Diabetes Nutr Metab. 2001;14(1):18-26.
Misra, A., Arora, N., Mondal, S., Pandey, R. M., Jailkhani, B., Peshin, S., Chaudhary, D., Saluja, T., Singh, P., Chandna, S., Luthra, K., & Vikram, N. K. (2001). Relation between plasma leptin and anthropometric and metabolic covariates in lean and obese diabetic and hyperlipidaemic Asian Northern Indian subjects. Diabetes, Nutrition & Metabolism, 14(1), 18-26.
Misra A, et al. Relation Between Plasma Leptin and Anthropometric and Metabolic Covariates in Lean and Obese Diabetic and Hyperlipidaemic Asian Northern Indian Subjects. Diabetes Nutr Metab. 2001;14(1):18-26. PubMed PMID: 11345162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between plasma leptin and anthropometric and metabolic covariates in lean and obese diabetic and hyperlipidaemic Asian Northern Indian subjects. AU - Misra,A, AU - Arora,N, AU - Mondal,S, AU - Pandey,R M, AU - Jailkhani,B, AU - Peshin,S, AU - Chaudhary,D, AU - Saluja,T, AU - Singh,P, AU - Chandna,S, AU - Luthra,K, AU - Vikram,N K, PY - 2001/5/10/pubmed PY - 2001/9/21/medline PY - 2001/5/10/entrez SP - 18 EP - 26 JF - Diabetes, nutrition & metabolism JO - Diabetes Nutr. Metab. VL - 14 IS - 1 N2 - This study investigated the relationship of plasma leptin to obesity, diabetes and hyperlipidaemia in Asian Northern Indian subjects, considered to have a predisposition to abdominal obesity and metabolic syndrome. A total of 72 subjects, subcategorised into lean and obese healthy subjects, lean and obese Type 2 diabetic and lean and obese non-diabetic hyperlipidaemic subjects were recruited. High leptin values were observed in all obese groups, and obese diabetic patients showed the highest levels. In lean and obese diabetic subjects, plasma leptin did not show any correlation to any index of glycaemia. When all lean and all obese subjects were analysed in two separate groups, body mass index (BMI), percent total body fat, and body density significantly correlated with the plasma leptin levels (p<0.05). Leptin values, when correlated to all variables in all patients taken together, showed the greatest magnitude of correlation with BMI (r=0.64), percent total body fat (r=0.67), and waist circumference (r=0.51). Strong inverse correlation was seen with body density (r=-0.67). Levels of serum insulin did not show any correlation with leptin levels in all subjects combined, and separately in various groups. Multiple linear regression analysis performed in obese, non-diabetic and normolipidaemic subjects, all Type 2 diabetic and all non-diabetic hyperlipidaemic subjects separately showed that percent total body fat is the only significant predictor of plasma leptin concentration in all the 3 groups. The present study suggests that plasma leptin has a strong positive correlation with percent total body fat in Asian Northern Indian subjects. Among other components of metabolic syndrome, only abdominal obesity is weakly correlated to serum leptin levels. SN - 0394-3402 UR - https://www.unboundmedicine.com/medline/citation/11345162/Relation_between_plasma_leptin_and_anthropometric_and_metabolic_covariates_in_lean_and_obese_diabetic_and_hyperlipidaemic_Asian_Northern_Indian_subjects_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -