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Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats.
Behav Neurosci. 2001 Apr; 115(2):365-75.BN

Abstract

C. Shi and M. Davis (1999) recently reported that combined lesions of the posterior extension of the intralaminar complex (PINT) and caudal insular cortex (INS) block acquisition but not expression of fear-potentiated startle to discrete conditioned stimuli (CSs) and a footshock unconditioned stimulus (US) and proposed that PINT-INS projections to the amygdala constitute the essential US pathways involved in fear conditioning. The present study further tested this hypothesis by examining whether PINT-INS lesions block fear conditioning (as measured by freezing) to diffuse-context and discrete-tone CSs, and whether posttraining lesions with continued CS-US training result in extinction to the CSs. Posttraining lesions resulted in a selective attenuation of tone conditioning, but context conditioning was unaffected by pre- and posttraining lesions. These results do not support the view that the PINT-INS represent the essential US pathway in fear conditioning.

Authors+Show Affiliations

Department of Psychology, Yale University, New Haven, Connecticut 06520-8205, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11345961

Citation

Brunzell, D H., and J J. Kim. "Fear Conditioning to Tone, but Not to Context, Is Attenuated By Lesions of the Insular Cortex and Posterior Extension of the Intralaminar Complex in Rats." Behavioral Neuroscience, vol. 115, no. 2, 2001, pp. 365-75.
Brunzell DH, Kim JJ. Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats. Behav Neurosci. 2001;115(2):365-75.
Brunzell, D. H., & Kim, J. J. (2001). Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats. Behavioral Neuroscience, 115(2), 365-75.
Brunzell DH, Kim JJ. Fear Conditioning to Tone, but Not to Context, Is Attenuated By Lesions of the Insular Cortex and Posterior Extension of the Intralaminar Complex in Rats. Behav Neurosci. 2001;115(2):365-75. PubMed PMID: 11345961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fear conditioning to tone, but not to context, is attenuated by lesions of the insular cortex and posterior extension of the intralaminar complex in rats. AU - Brunzell,D H, AU - Kim,J J, PY - 2001/5/11/pubmed PY - 2001/9/28/medline PY - 2001/5/11/entrez SP - 365 EP - 75 JF - Behavioral neuroscience JO - Behav Neurosci VL - 115 IS - 2 N2 - C. Shi and M. Davis (1999) recently reported that combined lesions of the posterior extension of the intralaminar complex (PINT) and caudal insular cortex (INS) block acquisition but not expression of fear-potentiated startle to discrete conditioned stimuli (CSs) and a footshock unconditioned stimulus (US) and proposed that PINT-INS projections to the amygdala constitute the essential US pathways involved in fear conditioning. The present study further tested this hypothesis by examining whether PINT-INS lesions block fear conditioning (as measured by freezing) to diffuse-context and discrete-tone CSs, and whether posttraining lesions with continued CS-US training result in extinction to the CSs. Posttraining lesions resulted in a selective attenuation of tone conditioning, but context conditioning was unaffected by pre- and posttraining lesions. These results do not support the view that the PINT-INS represent the essential US pathway in fear conditioning. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/11345961/Fear_conditioning_to_tone_but_not_to_context_is_attenuated_by_lesions_of_the_insular_cortex_and_posterior_extension_of_the_intralaminar_complex_in_rats_ L2 - http://content.apa.org/journals/bne/115/2/365 DB - PRIME DP - Unbound Medicine ER -