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Molecular characterization of field isolates of human pathogenic trypanosomes.
Trop Med Int Health. 2001 May; 6(5):401-6.TM

Abstract

The accurate identification of each of the three subspecies of Trypanosoma brucei remains a challenging problem in the epidemiology of sleeping sickness. Advances in molecular characterization have revealed a much greater degree of heterogeneity within the species than previously supposed. Only group 1 T. b. gambiense stands out as a separate entity, defined by several molecular markers. T. b. rhodesiense is generally too similar to sympatric T. b. brucei strains to be distinguished from them by any particular molecular markers. Nevertheless, characterization of trypanosome isolates from humans and other animals has allowed the identification of potential reservoir hosts of T. b. rhodesiense. The recent discovery of a gene for human serum resistance may provide a useful marker for T. b. rhodesiense in the future. There have been few attempts to find associations between genetic markers and other biological characters, except human infectivity. However, virulence or fly transmissibility have been correlated with molecular markers in some instances.

Authors+Show Affiliations

Gibson W
School of Biological Sciences, University of Bristol, Bristol, UK. w.gibson@bristol.ac.uk

MeSH

AfricaAnimalsDNA, ProtozoanDisease ReservoirsDrug ResistanceGenetic HeterogeneityGenetic MarkersHumansInsect VectorsMolecular BiologyMolecular EpidemiologyTrypanosoma brucei bruceiTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, AfricanTsetse Flies

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11348534

Citation

Gibson, W. "Molecular Characterization of Field Isolates of Human Pathogenic Trypanosomes." Tropical Medicine & International Health : TM & IH, vol. 6, no. 5, 2001, pp. 401-6.
Gibson W. Molecular characterization of field isolates of human pathogenic trypanosomes. Trop Med Int Health. 2001;6(5):401-6.
Gibson, W. (2001). Molecular characterization of field isolates of human pathogenic trypanosomes. Tropical Medicine & International Health : TM & IH, 6(5), 401-6.
Gibson W. Molecular Characterization of Field Isolates of Human Pathogenic Trypanosomes. Trop Med Int Health. 2001;6(5):401-6. PubMed PMID: 11348534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular characterization of field isolates of human pathogenic trypanosomes. A1 - Gibson,W, PY - 2001/5/12/pubmed PY - 2001/6/29/medline PY - 2001/5/12/entrez SP - 401 EP - 6 JF - Tropical medicine & international health : TM & IH JO - Trop Med Int Health VL - 6 IS - 5 N2 - The accurate identification of each of the three subspecies of Trypanosoma brucei remains a challenging problem in the epidemiology of sleeping sickness. Advances in molecular characterization have revealed a much greater degree of heterogeneity within the species than previously supposed. Only group 1 T. b. gambiense stands out as a separate entity, defined by several molecular markers. T. b. rhodesiense is generally too similar to sympatric T. b. brucei strains to be distinguished from them by any particular molecular markers. Nevertheless, characterization of trypanosome isolates from humans and other animals has allowed the identification of potential reservoir hosts of T. b. rhodesiense. The recent discovery of a gene for human serum resistance may provide a useful marker for T. b. rhodesiense in the future. There have been few attempts to find associations between genetic markers and other biological characters, except human infectivity. However, virulence or fly transmissibility have been correlated with molecular markers in some instances. SN - 1360-2276 UR - https://www.unboundmedicine.com/medline/citation/11348534/Molecular_characterization_of_field_isolates_of_human_pathogenic_trypanosomes_ DB - PRIME DP - Unbound Medicine ER -