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A vasoactive agent enhances the effect of ATP on cochlear blood flow.
Acta Otolaryngol. 2001 Jan; 121(2):130-4.AO

Abstract

Adenosine 5'-triphosphate (ATP) has a dual effect on cochlear blood flow (CBF). It induces on initial, transient decrease, which is followed by a long-lasting increase in CBF. Dilazep dihydrochloride (DZ) is a unique vasoactive agent, which increases CBF as well as decreases systemic blood pressure (BP). This agent is thought to keep the concentration of extracellular adenosine higher than normal by preventing the absorption of adenosine into the intracellular space. Thus, it may potentiate the effect of ATP on CBF. In this study, the effects are reported of ATP on CBF in the presence of DZ as measured with a laser Doppler flowmeter in the guinea pig cochlea. In the presence of DZ, the effect of ATP on CBF was amplified and prolonged. Specifically, the mean value of CBF initially decreased to 30.0% of the baseline, determined prior to administration of any agent, and increased gradually up to 287.8% of the baseline. This pharmaceutical effect of DZ might involve a longer activation of both P2x- and P2y-purinoceptors.

Authors+Show Affiliations

Department of Otolaryngology, Tsuchiura Kyodo Hospital, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11349763

Citation

Takago, H, et al. "A Vasoactive Agent Enhances the Effect of ATP On Cochlear Blood Flow." Acta Oto-laryngologica, vol. 121, no. 2, 2001, pp. 130-4.
Takago H, Yokoyama K, Kitamura K. A vasoactive agent enhances the effect of ATP on cochlear blood flow. Acta Otolaryngol. 2001;121(2):130-4.
Takago, H., Yokoyama, K., & Kitamura, K. (2001). A vasoactive agent enhances the effect of ATP on cochlear blood flow. Acta Oto-laryngologica, 121(2), 130-4.
Takago H, Yokoyama K, Kitamura K. A Vasoactive Agent Enhances the Effect of ATP On Cochlear Blood Flow. Acta Otolaryngol. 2001;121(2):130-4. PubMed PMID: 11349763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A vasoactive agent enhances the effect of ATP on cochlear blood flow. AU - Takago,H, AU - Yokoyama,K, AU - Kitamura,K, PY - 2001/5/15/pubmed PY - 2001/10/19/medline PY - 2001/5/15/entrez SP - 130 EP - 4 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 121 IS - 2 N2 - Adenosine 5'-triphosphate (ATP) has a dual effect on cochlear blood flow (CBF). It induces on initial, transient decrease, which is followed by a long-lasting increase in CBF. Dilazep dihydrochloride (DZ) is a unique vasoactive agent, which increases CBF as well as decreases systemic blood pressure (BP). This agent is thought to keep the concentration of extracellular adenosine higher than normal by preventing the absorption of adenosine into the intracellular space. Thus, it may potentiate the effect of ATP on CBF. In this study, the effects are reported of ATP on CBF in the presence of DZ as measured with a laser Doppler flowmeter in the guinea pig cochlea. In the presence of DZ, the effect of ATP on CBF was amplified and prolonged. Specifically, the mean value of CBF initially decreased to 30.0% of the baseline, determined prior to administration of any agent, and increased gradually up to 287.8% of the baseline. This pharmaceutical effect of DZ might involve a longer activation of both P2x- and P2y-purinoceptors. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/11349763/A_vasoactive_agent_enhances_the_effect_of_ATP_on_cochlear_blood_flow_ L2 - https://www.tandfonline.com/doi/full/10.1080/000164801300043181 DB - PRIME DP - Unbound Medicine ER -