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Oxidative stress in cystic fibrosis: dietary and metabolic factors.

Abstract

OBJECTIVE

To examine oxidative stress in CF by measuring 8-iso-PGF2alpha and antioxidant defenses, in relation to dietary intake, immune function and clinical status.

METHODS

We measured total plasma concentrations of 8-iso-PGF2alpha and dietary antioxidants (vitamin E, vitamin C, beta-carotene), erythrocyte antioxidant enzyme activities (glutathione peroxidase and superoxide dismutase), lung function and dietary intake in 21 CF subjects and 21 healthy age- and gender-matched controls.

RESULTS

Total plasma 8-iso-PGF2alpha concentration (median [quartile 1-quartile 3]) was significantly higher in CF subjects compared to controls (214 pg/mL (155-331) vs. 135 pg/mL (101-168), p = 0.001). Neutrophil, monocyte and total white cell counts were elevated in the CF group and these correlated with 8-iso-PGF2alpha concentration. Despite similar dietary intake, lower plasma antioxidant concentrations were observed in the CF group (vitamin E, p < 0.001, vitamin C, p = 0.004, beta-carotene, p = 0.001). 8-iso-PGF2alpha correlated negatively with plasma vitamin E, C and beta-carotene concentrations.

CONCLUSION

Oxidative stress is increased in CF patients, despite normal dietary antioxidant intake. The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed.

Authors+Show Affiliations

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Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales, Australia.

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Source

Journal of the American College of Nutrition 20:2 Suppl 2001 Apr pg 157-65

MeSH

Adolescent
Antioxidants
Case-Control Studies
Cystic Fibrosis
Dinoprost
Erythrocytes
F2-Isoprostanes
Female
Glutathione Peroxidase
Humans
Leukocytes
Male
Oxidative Stress
Respiratory Function Tests
Superoxide Dismutase
Vitamins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11349939

Citation

Wood, L G., et al. "Oxidative Stress in Cystic Fibrosis: Dietary and Metabolic Factors." Journal of the American College of Nutrition, vol. 20, no. 2 Suppl, 2001, pp. 157-65.
Wood LG, Fitzgerald DA, Gibson PG, et al. Oxidative stress in cystic fibrosis: dietary and metabolic factors. J Am Coll Nutr. 2001;20(2 Suppl):157-65.
Wood, L. G., Fitzgerald, D. A., Gibson, P. G., Cooper, D. M., Collins, C. E., & Garg, M. L. (2001). Oxidative stress in cystic fibrosis: dietary and metabolic factors. Journal of the American College of Nutrition, 20(2 Suppl), pp. 157-65.
Wood LG, et al. Oxidative Stress in Cystic Fibrosis: Dietary and Metabolic Factors. J Am Coll Nutr. 2001;20(2 Suppl):157-65. PubMed PMID: 11349939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in cystic fibrosis: dietary and metabolic factors. AU - Wood,L G, AU - Fitzgerald,D A, AU - Gibson,P G, AU - Cooper,D M, AU - Collins,C E, AU - Garg,M L, PY - 2001/5/15/pubmed PY - 2001/11/3/medline PY - 2001/5/15/entrez SP - 157 EP - 65 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 20 IS - 2 Suppl N2 - OBJECTIVE: To examine oxidative stress in CF by measuring 8-iso-PGF2alpha and antioxidant defenses, in relation to dietary intake, immune function and clinical status. METHODS: We measured total plasma concentrations of 8-iso-PGF2alpha and dietary antioxidants (vitamin E, vitamin C, beta-carotene), erythrocyte antioxidant enzyme activities (glutathione peroxidase and superoxide dismutase), lung function and dietary intake in 21 CF subjects and 21 healthy age- and gender-matched controls. RESULTS: Total plasma 8-iso-PGF2alpha concentration (median [quartile 1-quartile 3]) was significantly higher in CF subjects compared to controls (214 pg/mL (155-331) vs. 135 pg/mL (101-168), p = 0.001). Neutrophil, monocyte and total white cell counts were elevated in the CF group and these correlated with 8-iso-PGF2alpha concentration. Despite similar dietary intake, lower plasma antioxidant concentrations were observed in the CF group (vitamin E, p < 0.001, vitamin C, p = 0.004, beta-carotene, p = 0.001). 8-iso-PGF2alpha correlated negatively with plasma vitamin E, C and beta-carotene concentrations. CONCLUSION: Oxidative stress is increased in CF patients, despite normal dietary antioxidant intake. The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/11349939/Oxidative_stress_in_cystic_fibrosis:_dietary_and_metabolic_factors_ L2 - http://www.diseaseinfosearch.org/result/2071 DB - PRIME DP - Unbound Medicine ER -