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Oxidative stress in cystic fibrosis: dietary and metabolic factors.
J Am Coll Nutr 2001; 20(2 Suppl):157-65JA

Abstract

OBJECTIVE

To examine oxidative stress in CF by measuring 8-iso-PGF2alpha and antioxidant defenses, in relation to dietary intake, immune function and clinical status.

METHODS

We measured total plasma concentrations of 8-iso-PGF2alpha and dietary antioxidants (vitamin E, vitamin C, beta-carotene), erythrocyte antioxidant enzyme activities (glutathione peroxidase and superoxide dismutase), lung function and dietary intake in 21 CF subjects and 21 healthy age- and gender-matched controls.

RESULTS

Total plasma 8-iso-PGF2alpha concentration (median [quartile 1-quartile 3]) was significantly higher in CF subjects compared to controls (214 pg/mL (155-331) vs. 135 pg/mL (101-168), p = 0.001). Neutrophil, monocyte and total white cell counts were elevated in the CF group and these correlated with 8-iso-PGF2alpha concentration. Despite similar dietary intake, lower plasma antioxidant concentrations were observed in the CF group (vitamin E, p < 0.001, vitamin C, p = 0.004, beta-carotene, p = 0.001). 8-iso-PGF2alpha correlated negatively with plasma vitamin E, C and beta-carotene concentrations.

CONCLUSION

Oxidative stress is increased in CF patients, despite normal dietary antioxidant intake. The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed.

Authors+Show Affiliations

Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11349939

Citation

Wood, L G., et al. "Oxidative Stress in Cystic Fibrosis: Dietary and Metabolic Factors." Journal of the American College of Nutrition, vol. 20, no. 2 Suppl, 2001, pp. 157-65.
Wood LG, Fitzgerald DA, Gibson PG, et al. Oxidative stress in cystic fibrosis: dietary and metabolic factors. J Am Coll Nutr. 2001;20(2 Suppl):157-65.
Wood, L. G., Fitzgerald, D. A., Gibson, P. G., Cooper, D. M., Collins, C. E., & Garg, M. L. (2001). Oxidative stress in cystic fibrosis: dietary and metabolic factors. Journal of the American College of Nutrition, 20(2 Suppl), pp. 157-65.
Wood LG, et al. Oxidative Stress in Cystic Fibrosis: Dietary and Metabolic Factors. J Am Coll Nutr. 2001;20(2 Suppl):157-65. PubMed PMID: 11349939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress in cystic fibrosis: dietary and metabolic factors. AU - Wood,L G, AU - Fitzgerald,D A, AU - Gibson,P G, AU - Cooper,D M, AU - Collins,C E, AU - Garg,M L, PY - 2001/5/15/pubmed PY - 2001/11/3/medline PY - 2001/5/15/entrez SP - 157 EP - 65 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 20 IS - 2 Suppl N2 - OBJECTIVE: To examine oxidative stress in CF by measuring 8-iso-PGF2alpha and antioxidant defenses, in relation to dietary intake, immune function and clinical status. METHODS: We measured total plasma concentrations of 8-iso-PGF2alpha and dietary antioxidants (vitamin E, vitamin C, beta-carotene), erythrocyte antioxidant enzyme activities (glutathione peroxidase and superoxide dismutase), lung function and dietary intake in 21 CF subjects and 21 healthy age- and gender-matched controls. RESULTS: Total plasma 8-iso-PGF2alpha concentration (median [quartile 1-quartile 3]) was significantly higher in CF subjects compared to controls (214 pg/mL (155-331) vs. 135 pg/mL (101-168), p = 0.001). Neutrophil, monocyte and total white cell counts were elevated in the CF group and these correlated with 8-iso-PGF2alpha concentration. Despite similar dietary intake, lower plasma antioxidant concentrations were observed in the CF group (vitamin E, p < 0.001, vitamin C, p = 0.004, beta-carotene, p = 0.001). 8-iso-PGF2alpha correlated negatively with plasma vitamin E, C and beta-carotene concentrations. CONCLUSION: Oxidative stress is increased in CF patients, despite normal dietary antioxidant intake. The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/11349939/Oxidative_stress_in_cystic_fibrosis:_dietary_and_metabolic_factors_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2001.10719028 DB - PRIME DP - Unbound Medicine ER -