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Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study.
J Intern Med. 2001 May; 249(5):423-32.JI

Abstract

OBJECTIVES

The possibilities of detecting tissue cobalamin and folate deficiency are under debate. In this report the levels of serum cobalamin, folate, methylmalonic acid (MMA) and total homocysteine (tHcy) and their interrelations in a representative random population sample are presented.

DESIGN

Cohort study.

SETTING

A general mid-Swedish population.

SUBJECTS

A 20% random sample of persons 70 years or older in a defined geographical area were invited to a survey. A total of 235 (85%) persons responded, out of whom 224 had no interfering diseases.

MAIN OUTCOME MEASURES

Serum cobalamin, folate, MMA and tHcy.

RESULTS

The serum levels of cobalamin, folate, MMA and tHcy were all correlated to cobalamin and folic acid treatment. They were also correlated to the intake of multivitamin preparations. In addition, serum cobalamin was higher in untreated women than in men but not correlated to age. Serum folate was correlated neither to sex nor age. Serum tHcy and MMA were both directly correlated to age but MMA not to sex. MMA was inversely correlated to serum cobalamin but not to serum folate, whereas serum tHcy was inversely correlated to serum cobalamin, folate and creatinine. Neither serum cobalamin, folate, MMA nor tHcy had any significant correlation to haemoglobin, erythrocyte volume fraction (EVF) or mean red cell volume. Half of the study population had abnormal MMA or tHcy levels, suggesting a latent or overt tissue deficiency of cobalamin or folate.

CONCLUSIONS

A substantial proportion of the elderly general population had signs of low tissue levels of cobalamin or folate. Amongst those who took multivitamin preparations this proportion was much lower.

Authors+Show Affiliations

Uppsala University, Department of Public Health and Caring Sciences, Family Medicine Section, University Hospital, Sweden. karin.bjorkegren@allmmed.uu.seNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11350566

Citation

Björkegren, K, and K Svärdsudd. "Serum Cobalamin, Folate, Methylmalonic Acid and Total Homocysteine as Vitamin B12 and Folate Tissue Deficiency Markers Amongst Elderly Swedes--a Population-based Study." Journal of Internal Medicine, vol. 249, no. 5, 2001, pp. 423-32.
Björkegren K, Svärdsudd K. Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study. J Intern Med. 2001;249(5):423-32.
Björkegren, K., & Svärdsudd, K. (2001). Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study. Journal of Internal Medicine, 249(5), 423-32.
Björkegren K, Svärdsudd K. Serum Cobalamin, Folate, Methylmalonic Acid and Total Homocysteine as Vitamin B12 and Folate Tissue Deficiency Markers Amongst Elderly Swedes--a Population-based Study. J Intern Med. 2001;249(5):423-32. PubMed PMID: 11350566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cobalamin, folate, methylmalonic acid and total homocysteine as vitamin B12 and folate tissue deficiency markers amongst elderly Swedes--a population-based study. AU - Björkegren,K, AU - Svärdsudd,K, PY - 2001/5/15/pubmed PY - 2001/6/2/medline PY - 2001/5/15/entrez SP - 423 EP - 32 JF - Journal of internal medicine JO - J Intern Med VL - 249 IS - 5 N2 - OBJECTIVES: The possibilities of detecting tissue cobalamin and folate deficiency are under debate. In this report the levels of serum cobalamin, folate, methylmalonic acid (MMA) and total homocysteine (tHcy) and their interrelations in a representative random population sample are presented. DESIGN: Cohort study. SETTING: A general mid-Swedish population. SUBJECTS: A 20% random sample of persons 70 years or older in a defined geographical area were invited to a survey. A total of 235 (85%) persons responded, out of whom 224 had no interfering diseases. MAIN OUTCOME MEASURES: Serum cobalamin, folate, MMA and tHcy. RESULTS: The serum levels of cobalamin, folate, MMA and tHcy were all correlated to cobalamin and folic acid treatment. They were also correlated to the intake of multivitamin preparations. In addition, serum cobalamin was higher in untreated women than in men but not correlated to age. Serum folate was correlated neither to sex nor age. Serum tHcy and MMA were both directly correlated to age but MMA not to sex. MMA was inversely correlated to serum cobalamin but not to serum folate, whereas serum tHcy was inversely correlated to serum cobalamin, folate and creatinine. Neither serum cobalamin, folate, MMA nor tHcy had any significant correlation to haemoglobin, erythrocyte volume fraction (EVF) or mean red cell volume. Half of the study population had abnormal MMA or tHcy levels, suggesting a latent or overt tissue deficiency of cobalamin or folate. CONCLUSIONS: A substantial proportion of the elderly general population had signs of low tissue levels of cobalamin or folate. Amongst those who took multivitamin preparations this proportion was much lower. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/11350566/Serum_cobalamin_folate_methylmalonic_acid_and_total_homocysteine_as_vitamin_B12_and_folate_tissue_deficiency_markers_amongst_elderly_Swedes__a_population_based_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=2001&volume=249&issue=5&spage=423 DB - PRIME DP - Unbound Medicine ER -