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Primary sclerosing cholangitis.
Semin Gastrointest Dis 2001; 12(2):103-12SG

Abstract

Primary sclerosing cholangitis is a chronic cholestatic disease characterized by periductal inflammation of intrahepatic and extrahepatic bile ducts with obliterative fibrosis and duct loss. Significant loss of bile ducts leads to interference with bile flow and ultimately results in cirrhosis of the biliary type. Aside from viral hepatitis and alcoholic liver disease, primary sclerosing cholangitis is one of the most common indications for liver transplantation. Although there is no known beneficial therapy for these patients, research aimed toward better understanding the pathogenetic mechanisms and clinical trials with promising new agents are ongoing.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA. lindor.keith@mayo.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11352117

Citation

Zein, C O., and K D. Lindor. "Primary Sclerosing Cholangitis." Seminars in Gastrointestinal Disease, vol. 12, no. 2, 2001, pp. 103-12.
Zein CO, Lindor KD. Primary sclerosing cholangitis. Semin Gastrointest Dis. 2001;12(2):103-12.
Zein, C. O., & Lindor, K. D. (2001). Primary sclerosing cholangitis. Seminars in Gastrointestinal Disease, 12(2), pp. 103-12.
Zein CO, Lindor KD. Primary Sclerosing Cholangitis. Semin Gastrointest Dis. 2001;12(2):103-12. PubMed PMID: 11352117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary sclerosing cholangitis. AU - Zein,C O, AU - Lindor,K D, PY - 2001/5/16/pubmed PY - 2001/9/21/medline PY - 2001/5/16/entrez SP - 103 EP - 12 JF - Seminars in gastrointestinal disease JO - Semin. Gastrointest. Dis. VL - 12 IS - 2 N2 - Primary sclerosing cholangitis is a chronic cholestatic disease characterized by periductal inflammation of intrahepatic and extrahepatic bile ducts with obliterative fibrosis and duct loss. Significant loss of bile ducts leads to interference with bile flow and ultimately results in cirrhosis of the biliary type. Aside from viral hepatitis and alcoholic liver disease, primary sclerosing cholangitis is one of the most common indications for liver transplantation. Although there is no known beneficial therapy for these patients, research aimed toward better understanding the pathogenetic mechanisms and clinical trials with promising new agents are ongoing. SN - 1049-5118 UR - https://www.unboundmedicine.com/medline/citation/11352117/Primary_sclerosing_cholangitis_ L2 - http://www.diseaseinfosearch.org/result/5961 DB - PRIME DP - Unbound Medicine ER -