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Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure.
Arthritis Rheum. 2001 May; 44(5):1122-6.AR

Abstract

OBJECTIVE

The possible molecular mimicry of the Epstein-Barr virus (EBV) peptide PPPGRRP by the peptide PPPGMRPP from Sm B'/B of the human spliceosome is consistent with the possibility that EBV infection is related to the origin of systemic lupus erythematosus (SLE) in some patients. Association of EBV exposure with SLE was therefore tested for and subsequently found in children and adolescents (odds ratio [OR] 49.9, 95% confidence interval [95% CI] 9.3-1,025, P < 10(-11)). These results were confirmed at the level of EBV DNA (OR > 10, 95% CI 2.53-infinity, P < 0.002). Much smaller seroconversion rate differences were found against 4 other herpes viruses. Herein, we extend these studies to adults and test the hypothesis that EBV infection is associated with adult SLE.

METHODS

We selected 196 antinuclear antibody-positive adult SLE patients (age > or =20 years) and 2 age-, race-, and sex-matched controls per patient. SLE patients and matched controls were tested for evidence of previous infection with EBV, cytomegalovirus (CMV), herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), or varicella-zoster virus (VZV) by standardized enzyme-linked immunosorbent assays.

RESULTS

Of the 196 lupus patients tested, all but 1 had been exposed to EBV, while 22 of the 392 controls did not have antibodies consistent with previous EBV exposure (OR 9.35, 95% CI 1.45-infinity, P = 0.014). No differences were observed between SLE patients and controls in the seroconversion rate against CMV, HSV-2, or VZV.

CONCLUSION

These new data from adults, along with the many suggestive features of EBV infection, are consistent with the contribution of this infection to the etiology of SLE.

Authors+Show Affiliations

University of Oklahoma Health Sciences Center, Oklahoma City, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11352244

Citation

James, J A., et al. "Systemic Lupus Erythematosus in Adults Is Associated With Previous Epstein-Barr Virus Exposure." Arthritis and Rheumatism, vol. 44, no. 5, 2001, pp. 1122-6.
James JA, Neas BR, Moser KL, et al. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis Rheum. 2001;44(5):1122-6.
James, J. A., Neas, B. R., Moser, K. L., Hall, T., Bruner, G. R., Sestak, A. L., & Harley, J. B. (2001). Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis and Rheumatism, 44(5), 1122-6.
James JA, et al. Systemic Lupus Erythematosus in Adults Is Associated With Previous Epstein-Barr Virus Exposure. Arthritis Rheum. 2001;44(5):1122-6. PubMed PMID: 11352244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. AU - James,J A, AU - Neas,B R, AU - Moser,K L, AU - Hall,T, AU - Bruner,G R, AU - Sestak,A L, AU - Harley,J B, PY - 2001/5/16/pubmed PY - 2001/6/8/medline PY - 2001/5/16/entrez SP - 1122 EP - 6 JF - Arthritis and rheumatism JO - Arthritis Rheum VL - 44 IS - 5 N2 - OBJECTIVE: The possible molecular mimicry of the Epstein-Barr virus (EBV) peptide PPPGRRP by the peptide PPPGMRPP from Sm B'/B of the human spliceosome is consistent with the possibility that EBV infection is related to the origin of systemic lupus erythematosus (SLE) in some patients. Association of EBV exposure with SLE was therefore tested for and subsequently found in children and adolescents (odds ratio [OR] 49.9, 95% confidence interval [95% CI] 9.3-1,025, P < 10(-11)). These results were confirmed at the level of EBV DNA (OR > 10, 95% CI 2.53-infinity, P < 0.002). Much smaller seroconversion rate differences were found against 4 other herpes viruses. Herein, we extend these studies to adults and test the hypothesis that EBV infection is associated with adult SLE. METHODS: We selected 196 antinuclear antibody-positive adult SLE patients (age > or =20 years) and 2 age-, race-, and sex-matched controls per patient. SLE patients and matched controls were tested for evidence of previous infection with EBV, cytomegalovirus (CMV), herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), or varicella-zoster virus (VZV) by standardized enzyme-linked immunosorbent assays. RESULTS: Of the 196 lupus patients tested, all but 1 had been exposed to EBV, while 22 of the 392 controls did not have antibodies consistent with previous EBV exposure (OR 9.35, 95% CI 1.45-infinity, P = 0.014). No differences were observed between SLE patients and controls in the seroconversion rate against CMV, HSV-2, or VZV. CONCLUSION: These new data from adults, along with the many suggestive features of EBV infection, are consistent with the contribution of this infection to the etiology of SLE. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/11352244/Systemic_lupus_erythematosus_in_adults_is_associated_with_previous_Epstein_Barr_virus_exposure_ L2 - https://doi.org/10.1002/1529-0131(200105)44:5&lt;1122::AID-ANR193&gt;3.0.CO;2-D DB - PRIME DP - Unbound Medicine ER -