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Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning.
Neuroimage. 2001 Jun; 13(6 Pt 1):1044-52.N

Abstract

We used event-related fMRI to measure neural activity in volunteer subjects during acquisition of an implicit association between a visual conditioned stimulus (CS+) (angry face) and an auditory unconditioned stimulus (UCS) (aversive, loud noise). Three distinct functional regions were identified within left amygdala: a UCS (noise)-related lateral region, a CS+-related ventral region, and a dorsal region where CS+-related responses changed progressively across the learning session. Differential neural responses to the visual CS+ were also evoked in extrastriate and auditory cortices. Our results indicate that learning an association between biologically salient stimuli of different sensory modalities involves parallel changes of neural activity in segregated amygdala subregions and unimodal sensory cortices.

Authors+Show Affiliations

Morris JS
Wellcome Department of Cognitive Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Buchel C
No affiliation info available
Dolan RJ
No affiliation info available

MeSH

AdultAmygdalaAssociation LearningAuditory CortexBrain MappingConditioning, ClassicalFacial ExpressionFearFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysPattern Recognition, VisualSomatosensory CortexVisual Cortex

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11352610

Clinical Trial Links

Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder

Citation

Morris, J S., et al. "Parallel Neural Responses in Amygdala Subregions and Sensory Cortex During Implicit Fear Conditioning." NeuroImage, vol. 13, no. 6 Pt 1, 2001, pp. 1044-52.
Morris JS, Buchel C, Dolan RJ. Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. Neuroimage. 2001;13(6 Pt 1):1044-52.
Morris, J. S., Buchel, C., & Dolan, R. J. (2001). Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. NeuroImage, 13(6 Pt 1), 1044-52.
Morris JS, Buchel C, Dolan RJ. Parallel Neural Responses in Amygdala Subregions and Sensory Cortex During Implicit Fear Conditioning. Neuroimage. 2001;13(6 Pt 1):1044-52. PubMed PMID: 11352610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. AU - Morris,J S, AU - Buchel,C, AU - Dolan,R J, PY - 2001/5/16/pubmed PY - 2001/7/28/medline PY - 2001/5/16/entrez SP - 1044 EP - 52 JF - NeuroImage JO - Neuroimage VL - 13 IS - 6 Pt 1 N2 - We used event-related fMRI to measure neural activity in volunteer subjects during acquisition of an implicit association between a visual conditioned stimulus (CS+) (angry face) and an auditory unconditioned stimulus (UCS) (aversive, loud noise). Three distinct functional regions were identified within left amygdala: a UCS (noise)-related lateral region, a CS+-related ventral region, and a dorsal region where CS+-related responses changed progressively across the learning session. Differential neural responses to the visual CS+ were also evoked in extrastriate and auditory cortices. Our results indicate that learning an association between biologically salient stimuli of different sensory modalities involves parallel changes of neural activity in segregated amygdala subregions and unimodal sensory cortices. SN - 1053-8119 UR - https://www.unboundmedicine.com/medline/citation/11352610/Parallel_neural_responses_in_amygdala_subregions_and_sensory_cortex_during_implicit_fear_conditioning_ DB - PRIME DP - Unbound Medicine ER -