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Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts.
Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):429-37.CE

Abstract

Although most prospective cohort studies do not support an association between coffee consumption and pancreatic cancer, the findings for alcohol are inconsistent. Recently, a large prospective cohort study of women reported statistically significant elevations in risk of pancreatic cancer for both coffee and alcoholic beverage consumption. We obtained data on coffee, alcohol, and other dietary factors using semiquantitative food frequency questionnaires administered at baseline (1986 in the Health Professionals Follow-Up Study and 1980 in the Nurses' Health Study) and in subsequent follow-up questionnaires. Data on other risk factors for pancreatic cancer, including cigarette smoking, were also available. Individuals with a history of cancer at study initiation were excluded from all of the analyses. During the 1,907,222 person-years of follow-up, 288 incident cases of pancreatic cancer were diagnosed. The data were analyzed separately for each cohort, and results were pooled to compute overall relative risks (RR). Neither coffee nor alcohol intakes were associated with an increased risk of pancreatic cancer in either cohort or after pooling the results (pooled RR, 0.62; 95% confidence interval, 0.27-1.43, for >3 cups of coffee/day versus none; and pooled RR, 1.00; 95% confidence interval, 0.57-1.76, for > or = 30 grams of alcohol/day versus none). The associations did not change with analyses examining different latency periods for coffee and alcohol. Similarly, no statistically significant associations were observed for intakes of tea, decaffeinated coffee, total caffeine, or alcoholic beverages. Data from these two large cohorts do not support any overall association between coffee intake or alcohol intake and risk of pancreatic cancer.

Authors+Show Affiliations

Michaud DS
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. michaudd@mail.nih.gov
Giovannucci E
No affiliation info available
Willett WC
No affiliation info available
Colditz GA
No affiliation info available
Fuchs CS
No affiliation info available

MeSH

AdultAge DistributionAgedAlcohol DrinkingCoffeeCohort StudiesComorbidityConfidence IntervalsFemaleHumansIncidenceMaleMiddle AgedMultivariate AnalysisPancreatic NeoplasmsProbabilityProspective StudiesRisk AssessmentRisk FactorsSensitivity and SpecificitySex DistributionSurveys and QuestionnairesUnited States

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11352851

Citation

Michaud, D S., et al. "Coffee and Alcohol Consumption and the Risk of Pancreatic Cancer in Two Prospective United States Cohorts." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 10, no. 5, 2001, pp. 429-37.
Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev. 2001;10(5):429-37.
Michaud, D. S., Giovannucci, E., Willett, W. C., Colditz, G. A., & Fuchs, C. S. (2001). Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 10(5), 429-37.
Michaud DS, et al. Coffee and Alcohol Consumption and the Risk of Pancreatic Cancer in Two Prospective United States Cohorts. Cancer Epidemiol Biomarkers Prev. 2001;10(5):429-37. PubMed PMID: 11352851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. AU - Michaud,D S, AU - Giovannucci,E, AU - Willett,W C, AU - Colditz,G A, AU - Fuchs,C S, PY - 2001/5/16/pubmed PY - 2001/7/20/medline PY - 2001/5/16/entrez SP - 429 EP - 37 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 10 IS - 5 N2 - Although most prospective cohort studies do not support an association between coffee consumption and pancreatic cancer, the findings for alcohol are inconsistent. Recently, a large prospective cohort study of women reported statistically significant elevations in risk of pancreatic cancer for both coffee and alcoholic beverage consumption. We obtained data on coffee, alcohol, and other dietary factors using semiquantitative food frequency questionnaires administered at baseline (1986 in the Health Professionals Follow-Up Study and 1980 in the Nurses' Health Study) and in subsequent follow-up questionnaires. Data on other risk factors for pancreatic cancer, including cigarette smoking, were also available. Individuals with a history of cancer at study initiation were excluded from all of the analyses. During the 1,907,222 person-years of follow-up, 288 incident cases of pancreatic cancer were diagnosed. The data were analyzed separately for each cohort, and results were pooled to compute overall relative risks (RR). Neither coffee nor alcohol intakes were associated with an increased risk of pancreatic cancer in either cohort or after pooling the results (pooled RR, 0.62; 95% confidence interval, 0.27-1.43, for >3 cups of coffee/day versus none; and pooled RR, 1.00; 95% confidence interval, 0.57-1.76, for > or = 30 grams of alcohol/day versus none). The associations did not change with analyses examining different latency periods for coffee and alcohol. Similarly, no statistically significant associations were observed for intakes of tea, decaffeinated coffee, total caffeine, or alcoholic beverages. Data from these two large cohorts do not support any overall association between coffee intake or alcohol intake and risk of pancreatic cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/11352851/Coffee_and_alcohol_consumption_and_the_risk_of_pancreatic_cancer_in_two_prospective_United_States_cohorts_ DB - PRIME DP - Unbound Medicine ER -