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CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice.
Proc Natl Acad Sci U S A 2001; 98(11):6301-6PN

Abstract

Trimolecular interactions between the T cell antigen receptor and MHC/peptide complexes, together with costimulatory molecules and cytokines, control the initial activation of naive T cells and determine whether the helper precursor cell differentiates into either T helper (TH)1 or TH2 effector cells. We now present evidence that regulatory CD8(+) T cells provide another level of control of TH phenotype during further evolution of immune responses. These regulatory CD8(+) T cells are induced by antigen-triggered CD4(+) TH1 cells during T cell vaccination and, in vitro, distinguish mature TH1 from TH2 cells in a T cell antigen receptor Vbeta-specific and Qa-1-restricted manner. In vivo, protection from experimental autoimmune encephalomyelitis (EAE) induced by T cell vaccination depends on CD8(+) T cells, and myelin basic protein-reactive TH1 Vbeta8(+) clones, but not TH2 Vbeta8(+) clones, used as vaccine T cells, protect animals from subsequent induction of EAE. Moreover, in vivo depletion of CD8(+) T cells during the first episode of EAE results in skewing of the TH phenotype toward TH1 upon secondary myelin basic protein stimulation. These data provide evidence that CD8(+) T cells control autoimmune responses, in part, by regulating the TH phenotype of self-reactive CD4(+) T cells.

Authors+Show Affiliations

College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. hj4@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11353822

Citation

Jiang, H, et al. "CD8+ T Cells Control the TH Phenotype of MBP-reactive CD4+ T Cells in EAE Mice." Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 11, 2001, pp. 6301-6.
Jiang H, Braunstein NS, Yu B, et al. CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Natl Acad Sci USA. 2001;98(11):6301-6.
Jiang, H., Braunstein, N. S., Yu, B., Winchester, R., & Chess, L. (2001). CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proceedings of the National Academy of Sciences of the United States of America, 98(11), pp. 6301-6.
Jiang H, et al. CD8+ T Cells Control the TH Phenotype of MBP-reactive CD4+ T Cells in EAE Mice. Proc Natl Acad Sci USA. 2001 May 22;98(11):6301-6. PubMed PMID: 11353822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. AU - Jiang,H, AU - Braunstein,N S, AU - Yu,B, AU - Winchester,R, AU - Chess,L, Y1 - 2001/05/15/ PY - 2001/5/17/pubmed PY - 2001/7/20/medline PY - 2001/5/17/entrez SP - 6301 EP - 6 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 98 IS - 11 N2 - Trimolecular interactions between the T cell antigen receptor and MHC/peptide complexes, together with costimulatory molecules and cytokines, control the initial activation of naive T cells and determine whether the helper precursor cell differentiates into either T helper (TH)1 or TH2 effector cells. We now present evidence that regulatory CD8(+) T cells provide another level of control of TH phenotype during further evolution of immune responses. These regulatory CD8(+) T cells are induced by antigen-triggered CD4(+) TH1 cells during T cell vaccination and, in vitro, distinguish mature TH1 from TH2 cells in a T cell antigen receptor Vbeta-specific and Qa-1-restricted manner. In vivo, protection from experimental autoimmune encephalomyelitis (EAE) induced by T cell vaccination depends on CD8(+) T cells, and myelin basic protein-reactive TH1 Vbeta8(+) clones, but not TH2 Vbeta8(+) clones, used as vaccine T cells, protect animals from subsequent induction of EAE. Moreover, in vivo depletion of CD8(+) T cells during the first episode of EAE results in skewing of the TH phenotype toward TH1 upon secondary myelin basic protein stimulation. These data provide evidence that CD8(+) T cells control autoimmune responses, in part, by regulating the TH phenotype of self-reactive CD4(+) T cells. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/11353822/CD8+_T_cells_control_the_TH_phenotype_of_MBP_reactive_CD4+_T_cells_in_EAE_mice_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=11353822 DB - PRIME DP - Unbound Medicine ER -