Tags

Type your tag names separated by a space and hit enter

Adhesion molecules in different treatments of acute myocardial infarction.
Crit Care. 2001; 5(3):145-50.CC

Abstract

BACKGROUND

Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to determine the time course of soluble adhesion molecules in patients with acute myocardial infarction after attempted reperfusion by thrombolysis with tissue plasminogen activator (tPA) or streptokinase (SK), or percutaneous transluminal coronary angioplasty (PTCA).

METHODS

In 3 x 10 randomly selected patients with acute myocardial infarction undergoing thrombolysis with tPA or SK, or treated with PTCA, plasma concentrations of soluble L-selectin, P-selectin, E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) were measured by enzyme-linked immunosorbent assay, 30 min and 1, 2, 4, 8, 12 and 24 hours after intervention.

RESULTS

After thrombolysis with tPA, soluble L-selectin concentrations were persistently depressed and soluble PECAM-1 concentrations were elevated, compared with controls, SK and PTCA. While soluble VCAM-1 concentrations did not differ within the first hours after interventions between the three groups, soluble VCAM-1 rose by 24 hours after tPA thrombolysis but did not increase after SK and PTCA treatment. Soluble ICAM-1 concentrations were consistently elevated after PTCA compared with controls and thrombolysed patients. Soluble E-selectin was depressed after tPA thrombolysis and PTCA in comparison with controls, while the SK group showed an increase throughout the observation period. Soluble P-selectin was increased after PTCA and SK lysis up to 8 hours after treatment compared with controls, but no significant differences could be found between treatment groups.

CONCLUSION

Adhesion molecules mediating leukocyte endothelial interactions are altered subsequent to postischemic reperfusion and by treatment with thrombolytic agents and angioplasty. The clinical relevance of these biological changes remains to be determined.

Authors+Show Affiliations

Department of Anesthesiology and Intensive Care Medicine, Charité Medical Center, Virchow Hospital, Humboldt-University, Berlin, Germany. thoralf.kerner@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11353931

Citation

Kerner, T, et al. "Adhesion Molecules in Different Treatments of Acute Myocardial Infarction." Critical Care (London, England), vol. 5, no. 3, 2001, pp. 145-50.
Kerner T, Ahlers O, Reschreiter H, et al. Adhesion molecules in different treatments of acute myocardial infarction. Crit Care. 2001;5(3):145-50.
Kerner, T., Ahlers, O., Reschreiter, H., Bührer, C., Möckel, M., & Gerlach, H. (2001). Adhesion molecules in different treatments of acute myocardial infarction. Critical Care (London, England), 5(3), 145-50.
Kerner T, et al. Adhesion Molecules in Different Treatments of Acute Myocardial Infarction. Crit Care. 2001;5(3):145-50. PubMed PMID: 11353931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adhesion molecules in different treatments of acute myocardial infarction. AU - Kerner,T, AU - Ahlers,O, AU - Reschreiter,H, AU - Bührer,C, AU - Möckel,M, AU - Gerlach,H, Y1 - 2001/04/06/ PY - 2001/03/05/received PY - 2001/03/08/accepted PY - 2001/5/17/pubmed PY - 2001/8/17/medline PY - 2001/5/17/entrez SP - 145 EP - 50 JF - Critical care (London, England) JO - Crit Care VL - 5 IS - 3 N2 - BACKGROUND: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to determine the time course of soluble adhesion molecules in patients with acute myocardial infarction after attempted reperfusion by thrombolysis with tissue plasminogen activator (tPA) or streptokinase (SK), or percutaneous transluminal coronary angioplasty (PTCA). METHODS: In 3 x 10 randomly selected patients with acute myocardial infarction undergoing thrombolysis with tPA or SK, or treated with PTCA, plasma concentrations of soluble L-selectin, P-selectin, E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) were measured by enzyme-linked immunosorbent assay, 30 min and 1, 2, 4, 8, 12 and 24 hours after intervention. RESULTS: After thrombolysis with tPA, soluble L-selectin concentrations were persistently depressed and soluble PECAM-1 concentrations were elevated, compared with controls, SK and PTCA. While soluble VCAM-1 concentrations did not differ within the first hours after interventions between the three groups, soluble VCAM-1 rose by 24 hours after tPA thrombolysis but did not increase after SK and PTCA treatment. Soluble ICAM-1 concentrations were consistently elevated after PTCA compared with controls and thrombolysed patients. Soluble E-selectin was depressed after tPA thrombolysis and PTCA in comparison with controls, while the SK group showed an increase throughout the observation period. Soluble P-selectin was increased after PTCA and SK lysis up to 8 hours after treatment compared with controls, but no significant differences could be found between treatment groups. CONCLUSION: Adhesion molecules mediating leukocyte endothelial interactions are altered subsequent to postischemic reperfusion and by treatment with thrombolytic agents and angioplasty. The clinical relevance of these biological changes remains to be determined. SN - 1364-8535 UR - https://www.unboundmedicine.com/medline/citation/11353931/Adhesion_molecules_in_different_treatments_of_acute_myocardial_infarction_ L2 - https://ccforum.biomedcentral.com/articles/10.1186/cc1014 DB - PRIME DP - Unbound Medicine ER -