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Effect of castration, testosterone treatment and hereditary sterility on prostaglandin concentration in the male reproductive system of mice.
Prostaglandins. 1975 Feb; 9(2):289-97.P

Abstract

The concentration of prostaglandins E and F in different parts of the male reproductive system of CD-1 and dwarf mice was measured by radioimmunoassay. In intact CD-1 mice, the vas deferens contained a significantly higher concentration of PGE and PGF than was found in the epididymis and in the seminal vesicles. All tissues studied had more PGE than PGF. Castration resulted in increased PG concentrations in both the epididymis and the seminal vesicles and decreased PG concentrations in the vas deferens. There was also a differential response of PGE and PGF in the epididymis of genetically sterile dwarf mice (dw/dw) were significantly higher than those observed in their normal littermates ((PLUS)). A reversed PGE/PGF ratio was found in the mates. The results indicate that testicular androgens affect the levels of PGE and PGF in the reproductive system of male mice. The physiological role of PGs in male reproductive functions has not been established, but there is a suggestion that PH have a role in controlling the transit of spermatozoa through the epididymis and vas deferens.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1135441

Citation

Badr, F M., et al. "Effect of Castration, Testosterone Treatment and Hereditary Sterility On Prostaglandin Concentration in the Male Reproductive System of Mice." Prostaglandins, vol. 9, no. 2, 1975, pp. 289-97.
Badr FM, Barcikowski B, Bartke A. Effect of castration, testosterone treatment and hereditary sterility on prostaglandin concentration in the male reproductive system of mice. Prostaglandins. 1975;9(2):289-97.
Badr, F. M., Barcikowski, B., & Bartke, A. (1975). Effect of castration, testosterone treatment and hereditary sterility on prostaglandin concentration in the male reproductive system of mice. Prostaglandins, 9(2), 289-97.
Badr FM, Barcikowski B, Bartke A. Effect of Castration, Testosterone Treatment and Hereditary Sterility On Prostaglandin Concentration in the Male Reproductive System of Mice. Prostaglandins. 1975;9(2):289-97. PubMed PMID: 1135441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of castration, testosterone treatment and hereditary sterility on prostaglandin concentration in the male reproductive system of mice. AU - Badr,F M, AU - Barcikowski,B, AU - Bartke,A, PY - 1975/2/1/pubmed PY - 1975/2/1/medline PY - 1975/2/1/entrez SP - 289 EP - 97 JF - Prostaglandins JO - Prostaglandins VL - 9 IS - 2 N2 - The concentration of prostaglandins E and F in different parts of the male reproductive system of CD-1 and dwarf mice was measured by radioimmunoassay. In intact CD-1 mice, the vas deferens contained a significantly higher concentration of PGE and PGF than was found in the epididymis and in the seminal vesicles. All tissues studied had more PGE than PGF. Castration resulted in increased PG concentrations in both the epididymis and the seminal vesicles and decreased PG concentrations in the vas deferens. There was also a differential response of PGE and PGF in the epididymis of genetically sterile dwarf mice (dw/dw) were significantly higher than those observed in their normal littermates ((PLUS)). A reversed PGE/PGF ratio was found in the mates. The results indicate that testicular androgens affect the levels of PGE and PGF in the reproductive system of male mice. The physiological role of PGs in male reproductive functions has not been established, but there is a suggestion that PH have a role in controlling the transit of spermatozoa through the epididymis and vas deferens. SN - 0090-6980 UR - https://www.unboundmedicine.com/medline/citation/1135441/Effect_of_castration_testosterone_treatment_and_hereditary_sterility_on_prostaglandin_concentration_in_the_male_reproductive_system_of_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-6980(75)90033-7 DB - PRIME DP - Unbound Medicine ER -