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[MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain].
Sheng Li Xue Bao. 2001 Feb; 53(1):55-60.SL

Abstract

Using NADPH-d histochemistry, the effect of NMDA receptor antagonist MK-801 on the expression of nitric oxide synthase (NOS) in the dorsal horn of the spinal cord was investigated during inflammatory pain and hyperalgesia induced by injection of formalin into the right hind paw. The course of the change in the nitric oxide (NO) content of the lumbar intumescence was observed by measuring the ratio of nitrate/nitrite (NO3T/NO2T) and also the end product of NO. The results showed that the NOS expression and NO contents significantly increased 24 h after formalin injection, which were substantially inhibited when MK-801 was intrathecally injected 15 min prior to formalin injection or 12 h after formalin injection. The results suggest that the increases in the expression of NOS and NO contents in the dorsal horn of the spinal cord are mediated by activation of NMDA receptors during pain and hyperalgesia after formalin injection.

Authors+Show Affiliations

Department of Pathophysiology, Basic Medical Institute, Hebei Medical University, Shijiazhuang 050017.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11354799

Citation

Zeng, J B., et al. "[MK-801 Attenuates NOS Expression and NO Content in the Spinal Cord of Rats With Inflammatory Pain]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 53, no. 1, 2001, pp. 55-60.
Zeng JB, Li WB, Li QJ, et al. [MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain]. Sheng Li Xue Bao. 2001;53(1):55-60.
Zeng, J. B., Li, W. B., Li, Q. J., Chen, X. L., Zhou, A. M., & Ling, Y. L. (2001). [MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 53(1), 55-60.
Zeng JB, et al. [MK-801 Attenuates NOS Expression and NO Content in the Spinal Cord of Rats With Inflammatory Pain]. Sheng Li Xue Bao. 2001;53(1):55-60. PubMed PMID: 11354799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain]. AU - Zeng,J B, AU - Li,W B, AU - Li,Q J, AU - Chen,X L, AU - Zhou,A M, AU - Ling,Y L, PY - 2001/5/17/pubmed PY - 2002/10/31/medline PY - 2001/5/17/entrez SP - 55 EP - 60 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 53 IS - 1 N2 - Using NADPH-d histochemistry, the effect of NMDA receptor antagonist MK-801 on the expression of nitric oxide synthase (NOS) in the dorsal horn of the spinal cord was investigated during inflammatory pain and hyperalgesia induced by injection of formalin into the right hind paw. The course of the change in the nitric oxide (NO) content of the lumbar intumescence was observed by measuring the ratio of nitrate/nitrite (NO3T/NO2T) and also the end product of NO. The results showed that the NOS expression and NO contents significantly increased 24 h after formalin injection, which were substantially inhibited when MK-801 was intrathecally injected 15 min prior to formalin injection or 12 h after formalin injection. The results suggest that the increases in the expression of NOS and NO contents in the dorsal horn of the spinal cord are mediated by activation of NMDA receptors during pain and hyperalgesia after formalin injection. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/11354799/[MK_801_attenuates_NOS_expression_and_NO_content_in_the_spinal_cord_of_rats_with_inflammatory_pain]_ DB - PRIME DP - Unbound Medicine ER -