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Prognostic factors for influenza-associated hospitalization and death during an epidemic.

Abstract

To predict which patients with current high-risk disease in the community may benefit most from additional preventive or therapeutic measures for influenza, we determined prognostic factors for influenza-associated hospitalization and death in a general practice-based case-control study among this segment of the vaccine target population with high influenza vaccination rates. In 103 general practices followed during the 1996/7 influenza epidemic, cases were either hospitalized, or died due to influenza, bronchitis, pneumonia, diabetes, heart failure or myocardial infarction. Age- and gender-matched controls were randomly sampled from the remaining cohort. Information was collected by review of patient records. In total, 119 cases and 196 matched controls were included. Of the cases, 34, 25 and 4% were hospitalized for acute pulmonary and cardiac disease and diabetes, respectively, and 37% died. Multivariate conditional logistic regression analysis revealed that presence of chronic obstructive pulmonary disease, heart failure, previous hospitalization, high GP visiting rate and polypharmacy were independent prognostic factors. Several non-modifiable determinants can be used to ensure targeting additional preventive or therapeutic measures at the most vulnerable segment of the vaccine target group.

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  • Authors+Show Affiliations

    ,

    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands.

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    Source

    Epidemiology and infection 126:2 2001 Apr pg 261-8

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Disease Outbreaks
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Insurance, Health
    Length of Stay
    Lung Diseases
    Male
    Middle Aged
    Netherlands
    Prognosis

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11357897

    Citation

    Hak, E, et al. "Prognostic Factors for Influenza-associated Hospitalization and Death During an Epidemic." Epidemiology and Infection, vol. 126, no. 2, 2001, pp. 261-8.
    Hak E, Verheij TJ, van Essen GA, et al. Prognostic factors for influenza-associated hospitalization and death during an epidemic. Epidemiol Infect. 2001;126(2):261-8.
    Hak, E., Verheij, T. J., van Essen, G. A., Lafeber, A. B., Grobbee, D. E., & Hoes, A. W. (2001). Prognostic factors for influenza-associated hospitalization and death during an epidemic. Epidemiology and Infection, 126(2), pp. 261-8.
    Hak E, et al. Prognostic Factors for Influenza-associated Hospitalization and Death During an Epidemic. Epidemiol Infect. 2001;126(2):261-8. PubMed PMID: 11357897.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prognostic factors for influenza-associated hospitalization and death during an epidemic. AU - Hak,E, AU - Verheij,T J, AU - van Essen,G A, AU - Lafeber,A B, AU - Grobbee,D E, AU - Hoes,A W, PY - 2001/5/19/pubmed PY - 2001/6/2/medline PY - 2001/5/19/entrez SP - 261 EP - 8 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 126 IS - 2 N2 - To predict which patients with current high-risk disease in the community may benefit most from additional preventive or therapeutic measures for influenza, we determined prognostic factors for influenza-associated hospitalization and death in a general practice-based case-control study among this segment of the vaccine target population with high influenza vaccination rates. In 103 general practices followed during the 1996/7 influenza epidemic, cases were either hospitalized, or died due to influenza, bronchitis, pneumonia, diabetes, heart failure or myocardial infarction. Age- and gender-matched controls were randomly sampled from the remaining cohort. Information was collected by review of patient records. In total, 119 cases and 196 matched controls were included. Of the cases, 34, 25 and 4% were hospitalized for acute pulmonary and cardiac disease and diabetes, respectively, and 37% died. Multivariate conditional logistic regression analysis revealed that presence of chronic obstructive pulmonary disease, heart failure, previous hospitalization, high GP visiting rate and polypharmacy were independent prognostic factors. Several non-modifiable determinants can be used to ensure targeting additional preventive or therapeutic measures at the most vulnerable segment of the vaccine target group. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/11357897/Prognostic_factors_for_influenza_associated_hospitalization_and_death_during_an_epidemic_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/11357897/ DB - PRIME DP - Unbound Medicine ER -