TY - JOUR T1 - Application of capillary electrophoresis with laser-induced fluorescence detection to the determination of biogenic amines and amino acids in brain microdialysate and homogenate samples. AU - Chen,Z, AU - Wu,J, AU - Baker,G B, AU - Parent,M, AU - Dovichi,N J, PY - 2001/5/19/pubmed PY - 2001/9/14/medline PY - 2001/5/19/entrez SP - 293 EP - 8 JF - Journal of chromatography. A JO - J Chromatogr A VL - 914 IS - 1-2 N2 - A procedure is described to derivatize 16 primary-amine-containing biogenic amines and amino acids in brain mixtures with the fluorogenic reagent 5-furoylquinoline-3-carboxaldehyde (FQ). These FQ-tagged compounds in the brain sample were resolved in less than 16 min based on micellar electrokinetic chromatography and laser-induced fluorescence. There was a linear relationship between the concentration of analyte and the fluorescence intensity, with correlation coefficients in the range of 0.96-1.00. The utility of this method for the quantification of the important inhibitory neurotransmitter gamma-aminobutyric acid in microdialysates and brain homogenates from rats is illustrated. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/11358224/Application_of_capillary_electrophoresis_with_laser_induced_fluorescence_detection_to_the_determination_of_biogenic_amines_and_amino_acids_in_brain_microdialysate_and_homogenate_samples_ DB - PRIME DP - Unbound Medicine ER -