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Increased concentration of fecal alpha1-antitrypsin is associated with cow's milk allergy in infants with atopic eczema.
Clin Exp Allergy 2001; 31(4):590-2CE

Abstract

BACKGROUND

The use of fecal alpha1-antitrypsin in the monitoring of intestinal inflammation in infants with atopic eczema and food allergy was evaluated.

METHODS

The study material comprised 26 atopic infants with confirmed food allergy. Fecal samples were collected before an elimination diet and 3 months later for the determination of alpha1-antitrypsin.

RESULTS

Nine (35%) of the 26 patients demonstrated an increased fecal concentration of alpha1-antitrypsin (median 3 mg/g; range 2.8-6.4 mg/g). In all nine patients (100%) the oral cow's milk challenge was positive as opposed to only six (35%) in those with normal alpha1-antitrypsin concentration (P = 0.0024). No further connections between alpha1-antitrypsin and other food allergies were detected. As a result of an adequate elimination diet, the fecal concentration of alpha1-antitrypsin was normalized in seven patients, with a favourable clinical response in atopic eczema in six and no improvement in one patient.

CONCLUSIONS

Our results indicate that serial determinations of fecal alpha1-antitrypsin provide a useful non-invasive tool for the detection and follow-up of intestinal inflammation in a certain group of atopic infants with cow's milk allergy and severe inflammation of the gut.

Authors+Show Affiliations

Medical School, University of Tampere, Department of Dermatology and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11359427

Citation

Majamaa, H, et al. "Increased Concentration of Fecal Alpha1-antitrypsin Is Associated With Cow's Milk Allergy in Infants With Atopic Eczema." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 31, no. 4, 2001, pp. 590-2.
Majamaa H, Aittoniemi J, Miettinen A. Increased concentration of fecal alpha1-antitrypsin is associated with cow's milk allergy in infants with atopic eczema. Clin Exp Allergy. 2001;31(4):590-2.
Majamaa, H., Aittoniemi, J., & Miettinen, A. (2001). Increased concentration of fecal alpha1-antitrypsin is associated with cow's milk allergy in infants with atopic eczema. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 31(4), pp. 590-2.
Majamaa H, Aittoniemi J, Miettinen A. Increased Concentration of Fecal Alpha1-antitrypsin Is Associated With Cow's Milk Allergy in Infants With Atopic Eczema. Clin Exp Allergy. 2001;31(4):590-2. PubMed PMID: 11359427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased concentration of fecal alpha1-antitrypsin is associated with cow's milk allergy in infants with atopic eczema. AU - Majamaa,H, AU - Aittoniemi,J, AU - Miettinen,A, PY - 2001/5/22/pubmed PY - 2001/8/10/medline PY - 2001/5/22/entrez SP - 590 EP - 2 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 31 IS - 4 N2 - BACKGROUND: The use of fecal alpha1-antitrypsin in the monitoring of intestinal inflammation in infants with atopic eczema and food allergy was evaluated. METHODS: The study material comprised 26 atopic infants with confirmed food allergy. Fecal samples were collected before an elimination diet and 3 months later for the determination of alpha1-antitrypsin. RESULTS: Nine (35%) of the 26 patients demonstrated an increased fecal concentration of alpha1-antitrypsin (median 3 mg/g; range 2.8-6.4 mg/g). In all nine patients (100%) the oral cow's milk challenge was positive as opposed to only six (35%) in those with normal alpha1-antitrypsin concentration (P = 0.0024). No further connections between alpha1-antitrypsin and other food allergies were detected. As a result of an adequate elimination diet, the fecal concentration of alpha1-antitrypsin was normalized in seven patients, with a favourable clinical response in atopic eczema in six and no improvement in one patient. CONCLUSIONS: Our results indicate that serial determinations of fecal alpha1-antitrypsin provide a useful non-invasive tool for the detection and follow-up of intestinal inflammation in a certain group of atopic infants with cow's milk allergy and severe inflammation of the gut. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/11359427/Increased_concentration_of_fecal_alpha1_antitrypsin_is_associated_with_cow's_milk_allergy_in_infants_with_atopic_eczema_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2001&volume=31&issue=4&spage=590 DB - PRIME DP - Unbound Medicine ER -