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Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation.

Abstract

OBJECTIVE

To characterize circulating carotenoid and tocopherol levels in Nepali women during pregnancy and post-partum and to determine the effects of beta-carotene and vitamin A supplementation on their concentration in serum.

DESIGN

Randomized community supplementation trial.

SETTING

The study was carried out from 1994 to 1997 in the Southern, rural plains District of Sarlahi, Nepal.

SUBJECTS

A total of 1431 married women had an ascertained pregnancy, of whom 1186 (83%) provided an analyzable serum sample during pregnancy; 1098 (77%) provided an analyzable 3-4 months post-partum serum sample.

INTERVENTIONS

Women received a weekly dose of vitamin A (7000 microg RE), beta-carotene (42 mg) or placebo before, during and after pregnancy. Serum was analyzed for retinol, alpha-tocopherol, gamma-tocopherol, beta-carotene, alpha-carotene, lycopene, lutein + zeaxanthin, and beta-cryptoxanthin concentrations during mid-pregnancy and at approximately 3 months post-partum.

RESULTS

Compared to placebo, serum retinol, beta-carotene, gamma-tocopherol, beta-cryptoxanthin and lutein + zeaxanthin concentrations were higher among beta-carotene recipients during pregnancy and, except for beta-cryptoxanthin, at postpartum. In the vitamin A group, serum retinol and beta-cryptoxanthin were higher during pregnancy, and retinol and gamma-tocopherol higher at postpartum. Lutein + zeaxanthin was the dominant carotenoid, regardless of treatment group, followed by serum beta-carotene. Serum lycopene level was lowest, and very low compared to the US population. Serum retinol was higher, and carotenoid and alpha-tocopherol lower, at postpartum than during pregnancy in all groups.

CONCLUSIONS

Pregnant and lactating Nepali women have lower serum carotenoid and tocopherol levels than well-nourished populations. beta-carotene supplementation appeared to increase levels of tocopherol and other carotenoids in this population.

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  • Authors+Show Affiliations

    ,

    Center for Human Nutrition, Department of International Health and the Sight and Life Institute, The Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

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    Source

    MeSH

    Adult
    Carotenoids
    Dietary Supplements
    Female
    Humans
    Nepal
    Postpartum Period
    Pregnancy
    Rural Population
    Vitamin A
    Vitamin E
    beta Carotene

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11360129

    Citation

    Yamini, S, et al. "Circulating Levels of Retinol, Tocopherol and Carotenoid in Nepali Pregnant and Postpartum Women Following Long-term Beta-carotene and Vitamin a Supplementation." European Journal of Clinical Nutrition, vol. 55, no. 4, 2001, pp. 252-9.
    Yamini S, West KP, Wu L, et al. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. Eur J Clin Nutr. 2001;55(4):252-9.
    Yamini, S., West, K. P., Wu, L., Dreyfuss, M. L., Yang, D. X., & Khatry, S. K. (2001). Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. European Journal of Clinical Nutrition, 55(4), pp. 252-9.
    Yamini S, et al. Circulating Levels of Retinol, Tocopherol and Carotenoid in Nepali Pregnant and Postpartum Women Following Long-term Beta-carotene and Vitamin a Supplementation. Eur J Clin Nutr. 2001;55(4):252-9. PubMed PMID: 11360129.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. AU - Yamini,S, AU - West,K P,Jr AU - Wu,L, AU - Dreyfuss,M L, AU - Yang,D X, AU - Khatry,S K, PY - 2000/05/02/received PY - 2000/11/02/revised PY - 2000/11/06/accepted PY - 2001/5/22/pubmed PY - 2001/8/31/medline PY - 2001/5/22/entrez SP - 252 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 4 N2 - OBJECTIVE: To characterize circulating carotenoid and tocopherol levels in Nepali women during pregnancy and post-partum and to determine the effects of beta-carotene and vitamin A supplementation on their concentration in serum. DESIGN: Randomized community supplementation trial. SETTING: The study was carried out from 1994 to 1997 in the Southern, rural plains District of Sarlahi, Nepal. SUBJECTS: A total of 1431 married women had an ascertained pregnancy, of whom 1186 (83%) provided an analyzable serum sample during pregnancy; 1098 (77%) provided an analyzable 3-4 months post-partum serum sample. INTERVENTIONS: Women received a weekly dose of vitamin A (7000 microg RE), beta-carotene (42 mg) or placebo before, during and after pregnancy. Serum was analyzed for retinol, alpha-tocopherol, gamma-tocopherol, beta-carotene, alpha-carotene, lycopene, lutein + zeaxanthin, and beta-cryptoxanthin concentrations during mid-pregnancy and at approximately 3 months post-partum. RESULTS: Compared to placebo, serum retinol, beta-carotene, gamma-tocopherol, beta-cryptoxanthin and lutein + zeaxanthin concentrations were higher among beta-carotene recipients during pregnancy and, except for beta-cryptoxanthin, at postpartum. In the vitamin A group, serum retinol and beta-cryptoxanthin were higher during pregnancy, and retinol and gamma-tocopherol higher at postpartum. Lutein + zeaxanthin was the dominant carotenoid, regardless of treatment group, followed by serum beta-carotene. Serum lycopene level was lowest, and very low compared to the US population. Serum retinol was higher, and carotenoid and alpha-tocopherol lower, at postpartum than during pregnancy in all groups. CONCLUSIONS: Pregnant and lactating Nepali women have lower serum carotenoid and tocopherol levels than well-nourished populations. beta-carotene supplementation appeared to increase levels of tocopherol and other carotenoids in this population. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11360129/Circulating_levels_of_retinol_tocopherol_and_carotenoid_in_Nepali_pregnant_and_postpartum_women_following_long_term_beta_carotene_and_vitamin_A_supplementation_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601152 DB - PRIME DP - Unbound Medicine ER -