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Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract.
Eur J Clin Nutr 2001; 55(4):293-7EJ

Abstract

OBJECTIVE

To evaluate the effect of oral administration of selenium and zinc tablets in patients with cancer of the digestive tract during chemotherapy.

DESIGN

A case-control, randomized study.

SETTING

Medical Oncology, II University of Naples, Naples, Italy.

SUBJECTS

A total of 60 patients (median age 55 y, range 46-61 y) with diagnosis of gut cancer were randomized in 1999. Patients were treated for 60 days with chemotherapy.

INTERVENTIONS

Trace elements were measured by atomic absorption spectroscopy. The nutritional status of the patients was assessed by biochemical and bio-impedance analysis (BIA) parameters in basal condition and after 60 days of treatment. Oral administration of selenium and zinc in oral tablet form for 50 days was Se 200 microg/day (50 microg/tablet) and Zn 21 mg/day (7 mg/tablet).

RESULTS

Both in the basal condition and at 60 days all patients were malnourished. Selenium and zinc concentrations were significantly lower (P < 0.01) whereas copper concentration was significantly higher (P < 0.01) in cancer patients than in control subjects. However, 21/30 (70%) of those treated with Se and Zn did not showed a further worsening of nutritional status and experienced a significant decrease of asthenia with an increase of appetite. On the other hand, 24/30 (80%) untreated patients had a significant decline of all parameters studied after 60 days (prealbumin, cholesterol, transferrin, P < 0.05 vs 0 time; total proteins, albumin/globulin ratio, P < 0.01 vs 0 time; fat-free mass, fat mass, Na+/K+ ratio, body mass index P < 0.05 vs 0 time; fat free mass/fat mass, total body water, extra cellular/intra cellular water, basal metabolic rate: P < 0.01 vs 0 time).

CONCLUSIONS

Data indicate that Se and Zn supplementation may improve the clinical course of general conditions in patients with gut cancer. These effects of Se and Zn require confirmation in an independent trial of appropriate design before new public health recommendations regarding Se and Zn supplementation can be made.

Authors+Show Affiliations

Semeiotics and Clinical Methodology, II University of Naples, Naples, Italy. alefederico@yahoo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11360134

Citation

Federico, A, et al. "Effects of Selenium and Zinc Supplementation On Nutritional Status in Patients With Cancer of Digestive Tract." European Journal of Clinical Nutrition, vol. 55, no. 4, 2001, pp. 293-7.
Federico A, Iodice P, Federico P, et al. Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. Eur J Clin Nutr. 2001;55(4):293-7.
Federico, A., Iodice, P., Federico, P., Del Rio, A., Mellone, M. C., Catalano, G., & Federico, P. (2001). Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. European Journal of Clinical Nutrition, 55(4), pp. 293-7.
Federico A, et al. Effects of Selenium and Zinc Supplementation On Nutritional Status in Patients With Cancer of Digestive Tract. Eur J Clin Nutr. 2001;55(4):293-7. PubMed PMID: 11360134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. AU - Federico,A, AU - Iodice,P, AU - Federico,P, AU - Del Rio,A, AU - Mellone,M C, AU - Catalano,G, AU - Federico,P, PY - 2000/03/20/received PY - 2000/11/16/revised PY - 2000/11/20/accepted PY - 2001/5/22/pubmed PY - 2001/8/31/medline PY - 2001/5/22/entrez SP - 293 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 4 N2 - OBJECTIVE: To evaluate the effect of oral administration of selenium and zinc tablets in patients with cancer of the digestive tract during chemotherapy. DESIGN: A case-control, randomized study. SETTING: Medical Oncology, II University of Naples, Naples, Italy. SUBJECTS: A total of 60 patients (median age 55 y, range 46-61 y) with diagnosis of gut cancer were randomized in 1999. Patients were treated for 60 days with chemotherapy. INTERVENTIONS: Trace elements were measured by atomic absorption spectroscopy. The nutritional status of the patients was assessed by biochemical and bio-impedance analysis (BIA) parameters in basal condition and after 60 days of treatment. Oral administration of selenium and zinc in oral tablet form for 50 days was Se 200 microg/day (50 microg/tablet) and Zn 21 mg/day (7 mg/tablet). RESULTS: Both in the basal condition and at 60 days all patients were malnourished. Selenium and zinc concentrations were significantly lower (P < 0.01) whereas copper concentration was significantly higher (P < 0.01) in cancer patients than in control subjects. However, 21/30 (70%) of those treated with Se and Zn did not showed a further worsening of nutritional status and experienced a significant decrease of asthenia with an increase of appetite. On the other hand, 24/30 (80%) untreated patients had a significant decline of all parameters studied after 60 days (prealbumin, cholesterol, transferrin, P < 0.05 vs 0 time; total proteins, albumin/globulin ratio, P < 0.01 vs 0 time; fat-free mass, fat mass, Na+/K+ ratio, body mass index P < 0.05 vs 0 time; fat free mass/fat mass, total body water, extra cellular/intra cellular water, basal metabolic rate: P < 0.01 vs 0 time). CONCLUSIONS: Data indicate that Se and Zn supplementation may improve the clinical course of general conditions in patients with gut cancer. These effects of Se and Zn require confirmation in an independent trial of appropriate design before new public health recommendations regarding Se and Zn supplementation can be made. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11360134/Effects_of_selenium_and_zinc_supplementation_on_nutritional_status_in_patients_with_cancer_of_digestive_tract_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601157 DB - PRIME DP - Unbound Medicine ER -