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Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin).
Clin Infect Dis. 2001 Jun 15; 32(12):1798-802.CI

Abstract

We compared recommended doses of 2 oral macrolide antibiotics (10 days of clarithromycin, 5 days of azithromycin) for eradicating group A streptococci from the throats of individuals aged > or = 12 years with symptomatic pharyngitis and a positive throat culture. Patients received either clarithromycin (250 mg b.i.d. for 10 days [n=260]) or azythromycin (500 mg on day 1, followed by 250 mg q.d. for 4 days [n=265]). Follow-up throat cultures were obtained both at 13--19 days and at 28--38 days. We evaluated 392 patients (median age, 26 years; clarithromycin, 194 patients; azyithromycin, 198 patients). Ten days of clarithromycin therapy was more effective than 5 days of azithromycin therapy in eradicating the organism (91% [176/194] vs. 82% [162/198]; P=.012). More than 97% of all streptococcal isolates were macrolide-sensitive. Whether these bacteriologic eradication rates were the result of the 2 macrolides compared or were due to differences in duration of therapy could not be determined, but the statistically significant difference in eradication of group A streptococci does raise additional questions about shortened courses of macrolide therapy for this common infection.

Authors+Show Affiliations

Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. kapla001@.umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11360224

Citation

Kaplan, E L., et al. "Macrolide Therapy of Group a Streptococcal Pharyngitis: 10 Days of Macrolide Therapy (clarithromycin) Is More Effective in Streptococcal Eradication Than 5 Days (azithromycin)." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 32, no. 12, 2001, pp. 1798-802.
Kaplan EL, Gooch III WM, Notario GF, et al. Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clin Infect Dis. 2001;32(12):1798-802.
Kaplan, E. L., Gooch III, W. M., Notario, G. F., & Craft, J. C. (2001). Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 32(12), 1798-802.
Kaplan EL, et al. Macrolide Therapy of Group a Streptococcal Pharyngitis: 10 Days of Macrolide Therapy (clarithromycin) Is More Effective in Streptococcal Eradication Than 5 Days (azithromycin). Clin Infect Dis. 2001 Jun 15;32(12):1798-802. PubMed PMID: 11360224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). AU - Kaplan,E L, AU - Gooch III,W M, AU - Notario,G F, AU - Craft,J C, Y1 - 2001/05/21/ PY - 2000/03/01/received PY - 2001/5/22/pubmed PY - 2001/9/14/medline PY - 2001/5/22/entrez SP - 1798 EP - 802 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 32 IS - 12 N2 - We compared recommended doses of 2 oral macrolide antibiotics (10 days of clarithromycin, 5 days of azithromycin) for eradicating group A streptococci from the throats of individuals aged > or = 12 years with symptomatic pharyngitis and a positive throat culture. Patients received either clarithromycin (250 mg b.i.d. for 10 days [n=260]) or azythromycin (500 mg on day 1, followed by 250 mg q.d. for 4 days [n=265]). Follow-up throat cultures were obtained both at 13--19 days and at 28--38 days. We evaluated 392 patients (median age, 26 years; clarithromycin, 194 patients; azyithromycin, 198 patients). Ten days of clarithromycin therapy was more effective than 5 days of azithromycin therapy in eradicating the organism (91% [176/194] vs. 82% [162/198]; P=.012). More than 97% of all streptococcal isolates were macrolide-sensitive. Whether these bacteriologic eradication rates were the result of the 2 macrolides compared or were due to differences in duration of therapy could not be determined, but the statistically significant difference in eradication of group A streptococci does raise additional questions about shortened courses of macrolide therapy for this common infection. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/11360224/Macrolide_therapy_of_group_A_streptococcal_pharyngitis:_10_days_of_macrolide_therapy__clarithromycin__is_more_effective_in_streptococcal_eradication_than_5_days__azithromycin__ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/320745 DB - PRIME DP - Unbound Medicine ER -