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[Analysis of MDMA and its metabolites in urine by GC and GC/MS].
Fa Yi Xue Za Zhi. 1998; 14(1):10-1, 24, 61.FY

Abstract

The purpose of this study is to investigate the metabolism of MDMA in the person and establish the methods for the determination of MDMA and its metabolites in urine. MDMA and its metabolite were isolated from urine by liquid-liquid extraction after acidic or enzymatic hydrolysis and were determined by GC/MS(EI, PCI) and GC/FID. The results showed that MDMA was metabolized to MDA and HMMA in man. MDA in the urine after MDMA administration was approximately 0.10-0.14 that of the parent drug. The sensitivity limits of methods were 2-50 ng/ml, and the recoveries were greater than 85%(CV < 10%). It is concluded that the methods were simple, quick and accurate for determining urine concentration of MDMA addicts. MDA/MDMA Ratio can be used to indicate whether the parent drug is taken alone or in combination with its active metabolite.

Authors+Show Affiliations

Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11360579

Citation

Shen, M, et al. "[Analysis of MDMA and Its Metabolites in Urine By GC and GC/MS]." Fa Yi Xue Za Zhi, vol. 14, no. 1, 1998, pp. 10-1, 24, 61.
Shen M, Yan W, Shen B, et al. [Analysis of MDMA and its metabolites in urine by GC and GC/MS]. Fa Yi Xue Za Zhi. 1998;14(1):10-1, 24, 61.
Shen, M., Yan, W., Shen, B., Xiang, P., Huang, Z., Liu, W., & Bo, J. (1998). [Analysis of MDMA and its metabolites in urine by GC and GC/MS]. Fa Yi Xue Za Zhi, 14(1), 10-1, 24, 61.
Shen M, et al. [Analysis of MDMA and Its Metabolites in Urine By GC and GC/MS]. Fa Yi Xue Za Zhi. 1998;14(1):10-1, 24, 61. PubMed PMID: 11360579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of MDMA and its metabolites in urine by GC and GC/MS]. AU - Shen,M, AU - Yan,W, AU - Shen,B, AU - Xiang,P, AU - Huang,Z, AU - Liu,W, AU - Bo,J, PY - 2001/5/22/pubmed PY - 2001/6/22/medline PY - 2001/5/22/entrez SP - 10-1, 24, 61 JF - Fa yi xue za zhi JO - Fa Yi Xue Za Zhi VL - 14 IS - 1 N2 - The purpose of this study is to investigate the metabolism of MDMA in the person and establish the methods for the determination of MDMA and its metabolites in urine. MDMA and its metabolite were isolated from urine by liquid-liquid extraction after acidic or enzymatic hydrolysis and were determined by GC/MS(EI, PCI) and GC/FID. The results showed that MDMA was metabolized to MDA and HMMA in man. MDA in the urine after MDMA administration was approximately 0.10-0.14 that of the parent drug. The sensitivity limits of methods were 2-50 ng/ml, and the recoveries were greater than 85%(CV < 10%). It is concluded that the methods were simple, quick and accurate for determining urine concentration of MDMA addicts. MDA/MDMA Ratio can be used to indicate whether the parent drug is taken alone or in combination with its active metabolite. SN - 1004-5619 UR - https://www.unboundmedicine.com/medline/citation/11360579/[Analysis_of_MDMA_and_its_metabolites_in_urine_by_GC_and_GC/MS]_ L2 - https://medlineplus.gov/clubdrugs.html DB - PRIME DP - Unbound Medicine ER -