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[The effect of inhibition of nitric oxide synthesis on vasoregulatory factors in pregnant rats].
Zhonghua Fu Chan Ke Za Zhi. 1999 Sep; 34(9):521-4.ZF

Abstract

OBJECTIVE

To study the effect of the inhibition of nitric oxide(NO) synthesis on plasma endothelin (ET), prostaglandlin I2(PGI2), thromboxane (TXA2) and angiotensin (ANGII) in pregnant rats, and to investigate the role of these factors in the pathogenesis of pregnancy-induced hypertension(PIH).

METHODS

Pregnant rats were divided into two groups randomly. Saline solution or L-nitro arginine methyl ester (L-NAME) 125 mg/day was given subcutaneously from day 14 of gestation till delivery. Systolic blood pressure, urine protein, platelet count, and weight of pups and placentae were determined. Plasma NO, ET, PGI2, TXA2 and ANGII were measured by RIA.

RESULTS

Pregnant rats which were given L-NAME produced physical signs similar to those of PIH, such as increase in systolic blood pressure (140.6 +/- 3.8) mmHg and urine protein (801.38 +/- 57.12) mg/L, and decrease in platelet count (533 +/- 42) x 10(9)/L and weight of pups and placentae. Compared with controls, plasma NO, PGI2 and ANG II were decreased significantly while plasma ET and TXA2 were increased significantly in rats given L-NAME.

CONCLUSION

Inhibition of NO synthesis can cause imbalance of several vaso-regulatory factors, which may be responsible for the pathogenesis of PIH.

Authors+Show Affiliations

Ma C
Obstetrics and Gynecology Hospital, Shanghai Medical University, Shanghai 200011.
Zhuang Y
No affiliation info available
Xu Y
No affiliation info available

MeSH

6-Ketoprostaglandin F1 alphaAngiotensin IIAnimalsEndothelin-1FemaleNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePre-EclampsiaPregnancyRandom AllocationRatsRats, WistarVasodilation

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11360634

Citation

Ma, C, et al. "[The Effect of Inhibition of Nitric Oxide Synthesis On Vasoregulatory Factors in Pregnant Rats]." Zhonghua Fu Chan Ke Za Zhi, vol. 34, no. 9, 1999, pp. 521-4.
Ma C, Zhuang Y, Xu Y. [The effect of inhibition of nitric oxide synthesis on vasoregulatory factors in pregnant rats]. Zhonghua Fu Chan Ke Za Zhi. 1999;34(9):521-4.
Ma, C., Zhuang, Y., & Xu, Y. (1999). [The effect of inhibition of nitric oxide synthesis on vasoregulatory factors in pregnant rats]. Zhonghua Fu Chan Ke Za Zhi, 34(9), 521-4.
Ma C, Zhuang Y, Xu Y. [The Effect of Inhibition of Nitric Oxide Synthesis On Vasoregulatory Factors in Pregnant Rats]. Zhonghua Fu Chan Ke Za Zhi. 1999;34(9):521-4. PubMed PMID: 11360634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of inhibition of nitric oxide synthesis on vasoregulatory factors in pregnant rats]. AU - Ma,C, AU - Zhuang,Y, AU - Xu,Y, PY - 2001/5/22/pubmed PY - 2001/6/8/medline PY - 2001/5/22/entrez SP - 521 EP - 4 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 34 IS - 9 N2 - OBJECTIVE: To study the effect of the inhibition of nitric oxide(NO) synthesis on plasma endothelin (ET), prostaglandlin I2(PGI2), thromboxane (TXA2) and angiotensin (ANGII) in pregnant rats, and to investigate the role of these factors in the pathogenesis of pregnancy-induced hypertension(PIH). METHODS: Pregnant rats were divided into two groups randomly. Saline solution or L-nitro arginine methyl ester (L-NAME) 125 mg/day was given subcutaneously from day 14 of gestation till delivery. Systolic blood pressure, urine protein, platelet count, and weight of pups and placentae were determined. Plasma NO, ET, PGI2, TXA2 and ANGII were measured by RIA. RESULTS: Pregnant rats which were given L-NAME produced physical signs similar to those of PIH, such as increase in systolic blood pressure (140.6 +/- 3.8) mmHg and urine protein (801.38 +/- 57.12) mg/L, and decrease in platelet count (533 +/- 42) x 10(9)/L and weight of pups and placentae. Compared with controls, plasma NO, PGI2 and ANG II were decreased significantly while plasma ET and TXA2 were increased significantly in rats given L-NAME. CONCLUSION: Inhibition of NO synthesis can cause imbalance of several vaso-regulatory factors, which may be responsible for the pathogenesis of PIH. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/11360634/[The_effect_of_inhibition_of_nitric_oxide_synthesis_on_vasoregulatory_factors_in_pregnant_rats]_ DB - PRIME DP - Unbound Medicine ER -