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I-stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release.
Acta Pharmacol Sin. 2000 Jul; 21(7):663-7.AP

Abstract

AIM

To determine whether the D1 agonistic action of (-)-stepholidine (SPD) on the medial prefrontal cortex (mPFC) neuron is involved in the modulation of evoked subcortical dopamine (DA) release from nucleus accumbens (NAc) of rats.

METHODS

With the microinjection of SPD into the mPFC, the ventral tegmental area (VTA)-stimulated or amphetamine (AMP)-evoked DA efflux in the NAc was detected by microdialysis + HPLC-ECD in the 6-hydroxydopamine (6-OHDA)-lesioned and intact rats.

RESULTS

The depletion of DA in the mPFC did not modify both the basal level and the VTA-stimulated DA efflux in the NAc, but significantly facilitated the AMP (20 mumol.L-1)-evoked DA efflux within the NAc. It indicates that the mPFC DA system is involved in the regulation of evoked DA release in the NAc. Besides, the AMP-evoked increase of the extracellular DA release in the NAc was significantly attenuated by SPD (10, 30 mmol.L-1) microinjection into the mPFC, though this injection of SPD could not alter the response of DA release by the stimulation of the VTA. Furthermore, the inhibitory effect of SPD on the AMP-evoked DA efflux could be partially reversed by intravenous administration of D1 antagonist Sch-23390 (1 mg.kg-1), but not by D2 antagonist spiperone.

CONCLUSION

SPD is capable of enhancing the function of D1 receptors in the mPFC, by which it facilitates the inhibition of DA release in the NAc.

Authors+Show Affiliations

Department of Pharmacology, Shanghai Institute of Materia Medica, Shanghai 200031, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11360679

Citation

Zhu, Z T., et al. "I-stepholidine Facilitates Inhibition of mPFC DA Receptors On Subcortical NAc DA Release." Acta Pharmacologica Sinica, vol. 21, no. 7, 2000, pp. 663-7.
Zhu ZT, Wu WR, Fu Y, et al. I-stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release. Acta Pharmacol Sin. 2000;21(7):663-7.
Zhu, Z. T., Wu, W. R., Fu, Y., & Jin, G. Z. (2000). I-stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release. Acta Pharmacologica Sinica, 21(7), 663-7.
Zhu ZT, et al. I-stepholidine Facilitates Inhibition of mPFC DA Receptors On Subcortical NAc DA Release. Acta Pharmacol Sin. 2000;21(7):663-7. PubMed PMID: 11360679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - I-stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release. AU - Zhu,Z T, AU - Wu,W R, AU - Fu,Y, AU - Jin,G Z, PY - 2001/5/22/pubmed PY - 2001/6/29/medline PY - 2001/5/22/entrez SP - 663 EP - 7 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 21 IS - 7 N2 - AIM: To determine whether the D1 agonistic action of (-)-stepholidine (SPD) on the medial prefrontal cortex (mPFC) neuron is involved in the modulation of evoked subcortical dopamine (DA) release from nucleus accumbens (NAc) of rats. METHODS: With the microinjection of SPD into the mPFC, the ventral tegmental area (VTA)-stimulated or amphetamine (AMP)-evoked DA efflux in the NAc was detected by microdialysis + HPLC-ECD in the 6-hydroxydopamine (6-OHDA)-lesioned and intact rats. RESULTS: The depletion of DA in the mPFC did not modify both the basal level and the VTA-stimulated DA efflux in the NAc, but significantly facilitated the AMP (20 mumol.L-1)-evoked DA efflux within the NAc. It indicates that the mPFC DA system is involved in the regulation of evoked DA release in the NAc. Besides, the AMP-evoked increase of the extracellular DA release in the NAc was significantly attenuated by SPD (10, 30 mmol.L-1) microinjection into the mPFC, though this injection of SPD could not alter the response of DA release by the stimulation of the VTA. Furthermore, the inhibitory effect of SPD on the AMP-evoked DA efflux could be partially reversed by intravenous administration of D1 antagonist Sch-23390 (1 mg.kg-1), but not by D2 antagonist spiperone. CONCLUSION: SPD is capable of enhancing the function of D1 receptors in the mPFC, by which it facilitates the inhibition of DA release in the NAc. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/11360679/I_stepholidine_facilitates_inhibition_of_mPFC_DA_receptors_on_subcortical_NAc_DA_release_ L2 - http://www.chinaphar.com/1671-4083/21/663.pdf DB - PRIME DP - Unbound Medicine ER -