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Role of amygdala norepinephrine in mediating stress hormone regulation of memory storage.
Acta Pharmacol Sin. 2000 Jun; 21(6):481-93.AP

Abstract

There is extensive evidence indicating that the noradrenergic system of the amygdala, particularly the basolateral nucleus of the amygdala (BLA), is involved in memory consolidation. This article reviews the central hypothesis that stress hormones released during emotionally arousing experiences activate noradrenergic mechanisms in the BLA, resulting in enhanced memory for those events. Findings from experiments using rats have shown that the memory-modulatory effects of the adrenocortical stress hormones epinephrine and glucocorticoids involve activation of beta-adrenoceptors in the BLA. In addition, both behavioral and microdialysis studies have shown that the noradrenergic system of the BLA also mediates the influences of other neuromodulatory systems such as opioid peptidergic and GABAergic systems on memory storage. Other findings indicate that this stress hormone-induced activation of noradrenergic mechanisms in the BLA regulates memory storage in other brain regions.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697-3800, USA. barbaraferry@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11360681

Citation

Ferry, B, and J L. McGaugh. "Role of Amygdala Norepinephrine in Mediating Stress Hormone Regulation of Memory Storage." Acta Pharmacologica Sinica, vol. 21, no. 6, 2000, pp. 481-93.
Ferry B, McGaugh JL. Role of amygdala norepinephrine in mediating stress hormone regulation of memory storage. Acta Pharmacol Sin. 2000;21(6):481-93.
Ferry, B., & McGaugh, J. L. (2000). Role of amygdala norepinephrine in mediating stress hormone regulation of memory storage. Acta Pharmacologica Sinica, 21(6), 481-93.
Ferry B, McGaugh JL. Role of Amygdala Norepinephrine in Mediating Stress Hormone Regulation of Memory Storage. Acta Pharmacol Sin. 2000;21(6):481-93. PubMed PMID: 11360681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of amygdala norepinephrine in mediating stress hormone regulation of memory storage. AU - Ferry,B, AU - McGaugh,J L, PY - 2001/5/22/pubmed PY - 2001/6/2/medline PY - 2001/5/22/entrez SP - 481 EP - 93 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 21 IS - 6 N2 - There is extensive evidence indicating that the noradrenergic system of the amygdala, particularly the basolateral nucleus of the amygdala (BLA), is involved in memory consolidation. This article reviews the central hypothesis that stress hormones released during emotionally arousing experiences activate noradrenergic mechanisms in the BLA, resulting in enhanced memory for those events. Findings from experiments using rats have shown that the memory-modulatory effects of the adrenocortical stress hormones epinephrine and glucocorticoids involve activation of beta-adrenoceptors in the BLA. In addition, both behavioral and microdialysis studies have shown that the noradrenergic system of the BLA also mediates the influences of other neuromodulatory systems such as opioid peptidergic and GABAergic systems on memory storage. Other findings indicate that this stress hormone-induced activation of noradrenergic mechanisms in the BLA regulates memory storage in other brain regions. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/11360681/Role_of_amygdala_norepinephrine_in_mediating_stress_hormone_regulation_of_memory_storage_ L2 - http://www.chinaphar.com/1671-4083/21/481.pdf DB - PRIME DP - Unbound Medicine ER -