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[Effects of prepartum infusion solutions on glucose and bilirubin metabolism of mother and child in the prepartum and postpartum period].

Abstract

BACKGROUND

Administration of glucose 5% infusion is regularly used in obstetrics. The purpose of the study was to investigate the effects of glucose as compared to xylose and electrolyte solutions on parameters of maternal and fetal glucose and bilirubin metabolism during labour and after delivery.

PATIENTS AND METHODS

53 pregnant women (> or = 37 weeks of gestation, uncomplicated pregnancies) were randomised by entering the delivery ward. Under labour either glucose 5%, xylose 5% or electrolyte infusions were administered. Maternal serum glucose, serum osmolarity, insulin and glucagon were analysed before administration and 20 minutes after delivery. In the newborn blood osmolarity and serum glucose levels were analysed in the umbilical cord directly after birth and in capillary blood samplings 2 hours after birth.

RESULTS

Maternal blood glucose levels 20 min. post partum were significantly different (p < 0.05). Maternal insulin and glucagon concentrations 20 min. pp showed similar trends with glucose levels but were not significantly different. Glucose levels in the umbilical cord were significantly higher in the glucose than in the electrolyte group, but not higher than in the Xylit group. In contrast, the glucose-levels in the newborns after 2 h were significantly higher in the glucose group compared with both other groups. No significant differences were observed in bilirubin levels. Osmolarity in the umbilical cord between groups differed significantly.

CONCLUSIONS AND DISCUSSION

In conclusion, the administration of different solutions showed a distinct influence on the maternal and neonatal glucose metabolism. A significant impact on the bilirubin levels could not be shown in this study.

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  • Authors+Show Affiliations

    ,

    Universitäts-Frauenklinik Würzburg. j.hofmann@mail.uni-wuerzburg.de

    , , ,

    Source

    MeSH

    Adult
    Bilirubin
    Blood Glucose
    Contrast Media
    Female
    Fetal Blood
    Fluid Therapy
    Glucose Solution, Hypertonic
    Humans
    Infant, Newborn
    Insulin
    Labor, Obstetric
    Maternal-Fetal Exchange
    Organic Chemicals
    Pregnancy

    Pub Type(s)

    Clinical Trial
    Comparative Study
    English Abstract
    Journal Article
    Randomized Controlled Trial

    Language

    ger

    PubMed ID

    11360851

    Citation

    Hofmann, J, et al. "[Effects of Prepartum Infusion Solutions On Glucose and Bilirubin Metabolism of Mother and Child in the Prepartum and Postpartum Period]." Zeitschrift Fur Geburtshilfe Und Neonatologie, vol. 205, no. 2, 2001, pp. 60-4.
    Hofmann J, Schrod L, Schleelein O, et al. [Effects of prepartum infusion solutions on glucose and bilirubin metabolism of mother and child in the prepartum and postpartum period]. Z Geburtshilfe Neonatol. 2001;205(2):60-4.
    Hofmann, J., Schrod, L., Schleelein, O., Springer, S., & Steck, T. (2001). [Effects of prepartum infusion solutions on glucose and bilirubin metabolism of mother and child in the prepartum and postpartum period]. Zeitschrift Fur Geburtshilfe Und Neonatologie, 205(2), pp. 60-4.
    Hofmann J, et al. [Effects of Prepartum Infusion Solutions On Glucose and Bilirubin Metabolism of Mother and Child in the Prepartum and Postpartum Period]. Z Geburtshilfe Neonatol. 2001;205(2):60-4. PubMed PMID: 11360851.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Effects of prepartum infusion solutions on glucose and bilirubin metabolism of mother and child in the prepartum and postpartum period]. AU - Hofmann,J, AU - Schrod,L, AU - Schleelein,O, AU - Springer,S, AU - Steck,T, PY - 2001/5/22/pubmed PY - 2001/8/3/medline PY - 2001/5/22/entrez SP - 60 EP - 4 JF - Zeitschrift fur Geburtshilfe und Neonatologie JO - Z Geburtshilfe Neonatol VL - 205 IS - 2 N2 - BACKGROUND: Administration of glucose 5% infusion is regularly used in obstetrics. The purpose of the study was to investigate the effects of glucose as compared to xylose and electrolyte solutions on parameters of maternal and fetal glucose and bilirubin metabolism during labour and after delivery. PATIENTS AND METHODS: 53 pregnant women (> or = 37 weeks of gestation, uncomplicated pregnancies) were randomised by entering the delivery ward. Under labour either glucose 5%, xylose 5% or electrolyte infusions were administered. Maternal serum glucose, serum osmolarity, insulin and glucagon were analysed before administration and 20 minutes after delivery. In the newborn blood osmolarity and serum glucose levels were analysed in the umbilical cord directly after birth and in capillary blood samplings 2 hours after birth. RESULTS: Maternal blood glucose levels 20 min. post partum were significantly different (p < 0.05). Maternal insulin and glucagon concentrations 20 min. pp showed similar trends with glucose levels but were not significantly different. Glucose levels in the umbilical cord were significantly higher in the glucose than in the electrolyte group, but not higher than in the Xylit group. In contrast, the glucose-levels in the newborns after 2 h were significantly higher in the glucose group compared with both other groups. No significant differences were observed in bilirubin levels. Osmolarity in the umbilical cord between groups differed significantly. CONCLUSIONS AND DISCUSSION: In conclusion, the administration of different solutions showed a distinct influence on the maternal and neonatal glucose metabolism. A significant impact on the bilirubin levels could not be shown in this study. SN - 0948-2393 UR - https://www.unboundmedicine.com/medline/citation/11360851/[Effects_of_prepartum_infusion_solutions_on_glucose_and_bilirubin_metabolism_of_mother_and_child_in_the_prepartum_and_postpartum_period]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-14822 DB - PRIME DP - Unbound Medicine ER -