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Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease.
Gynecol Oncol. 2001 Jun; 81(3):456-60.GO

Abstract

OBJECTIVES

The goal of this work was to evaluate clinical and pathological findings, surgical procedures, and postoperative treatment in women with stage I granulosa cell tumor.

METHODS

Data for 49 women with granulosa cell tumor were collected retrospectively. All pathological sections and findings were reviewed from diagnosis until recently. Follow-up data were collected from the general practitioner, hospital records, or death certificate. Fisher's exact test, Student's t test, Mann-Whitney test, and Kaplan-Meier survival analysis were applied, as appropriate.

RESULTS

Thirty-seven women of median age 58 years (range, 33-82) were diagnosed in stage I. Follow-up time was 8 years (range, 8 months to 26 years). The estimated survival for stage I was 93% at 5 years, 84% at 10 years, and 62% at 20 years; the actual survival rates were 94, 82, and 62% after 5, 10, and 20 years, respectively. Primary treatment consisting of total abdominal hysterectomy and bilateral salpingo-oophorectomy was associated with improved survival (P < 0.05) and tended to be associated with longer relapse-free interval (P < 0.06). The 10-year survival rate was 40% in postmenopausal women operated conservatively and more than 90% for the extensively treated women (P < 0.05). Evidence of increased estrogen secretion was found more often in postmenopausal woman as compared with premenopausal women (P < 0.01) but did not affect survival. No pathological parameter correlated with prognosis.

CONCLUSION

Granulosa cell tumor is a tumor of unquestionable malignant potential and has a tendency for late relapses. Long-time follow-up is recommended.

Authors+Show Affiliations

Department of Gynecology, Aarhus University Hospital, Aarhus, Denmark. affl@ringgamt.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11371138

Citation

Lauszus, F F., et al. "Granulosa Cell Tumor of the Ovary: a Population-based Study of 37 Women With Stage I Disease." Gynecologic Oncology, vol. 81, no. 3, 2001, pp. 456-60.
Lauszus FF, Petersen AC, Greisen J, et al. Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. Gynecol Oncol. 2001;81(3):456-60.
Lauszus, F. F., Petersen, A. C., Greisen, J., & Jakobsen, A. (2001). Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. Gynecologic Oncology, 81(3), 456-60.
Lauszus FF, et al. Granulosa Cell Tumor of the Ovary: a Population-based Study of 37 Women With Stage I Disease. Gynecol Oncol. 2001;81(3):456-60. PubMed PMID: 11371138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. AU - Lauszus,F F, AU - Petersen,A C, AU - Greisen,J, AU - Jakobsen,A, PY - 2001/5/24/pubmed PY - 2001/6/29/medline PY - 2001/5/24/entrez SP - 456 EP - 60 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 81 IS - 3 N2 - OBJECTIVES: The goal of this work was to evaluate clinical and pathological findings, surgical procedures, and postoperative treatment in women with stage I granulosa cell tumor. METHODS: Data for 49 women with granulosa cell tumor were collected retrospectively. All pathological sections and findings were reviewed from diagnosis until recently. Follow-up data were collected from the general practitioner, hospital records, or death certificate. Fisher's exact test, Student's t test, Mann-Whitney test, and Kaplan-Meier survival analysis were applied, as appropriate. RESULTS: Thirty-seven women of median age 58 years (range, 33-82) were diagnosed in stage I. Follow-up time was 8 years (range, 8 months to 26 years). The estimated survival for stage I was 93% at 5 years, 84% at 10 years, and 62% at 20 years; the actual survival rates were 94, 82, and 62% after 5, 10, and 20 years, respectively. Primary treatment consisting of total abdominal hysterectomy and bilateral salpingo-oophorectomy was associated with improved survival (P < 0.05) and tended to be associated with longer relapse-free interval (P < 0.06). The 10-year survival rate was 40% in postmenopausal women operated conservatively and more than 90% for the extensively treated women (P < 0.05). Evidence of increased estrogen secretion was found more often in postmenopausal woman as compared with premenopausal women (P < 0.01) but did not affect survival. No pathological parameter correlated with prognosis. CONCLUSION: Granulosa cell tumor is a tumor of unquestionable malignant potential and has a tendency for late relapses. Long-time follow-up is recommended. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/11371138/Granulosa_cell_tumor_of_the_ovary:_a_population_based_study_of_37_women_with_stage_I_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(01)96183-9 DB - PRIME DP - Unbound Medicine ER -