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Hypothalamic function in response to 2-deoxy-D-glucose in long-term abstinent alcoholics.
Alcohol Clin Exp Res. 2001 May; 25(5):781-6.AC

Abstract

BACKGROUND

The body adapts to diverse stressful stimuli with a response characterized by activation of the hypothalamic-pituitary-adrenal (HPA) axis. Chronic alcohol consumption can cause changes in the function of this neuroendocrine system. Although many studies have examined this phenomenon in drinking and recently sober alcoholics, few studies have examined HPA axis function in long-term sober alcoholics.

METHODS

To characterize HPA axis function in long-term sober alcoholics, we used a challenge paradigm with 2-deoxy-d-glucose (2-DG). An infusion of 2-DG (a nonmetabolizable glucose analog) induces a well-characterized stress response. In a previous study, our laboratory found an exaggerated corticotropin and cortisol response in alcoholics abstinent 3 weeks; in this investigation we compared the effects of an infusion of 2-DG on 19 healthy volunteers and 20 community-living alcoholics who had been abstinent more than 6 months.

RESULTS

In contrast to the previous study, long-term sober alcoholics did not have an exaggerated corticotropin and cortisol response after 2-DG.

CONCLUSIONS

Previously observed abnormalities in cortisol regulation in 3-week-sober alcoholics may be related to the acute effects of recent alcohol consumption and withdrawal. Future investigations into the metabolic function of alcoholics, particularly investigations involving the HPA system, should consider the possibility that normalization may not occur until long-term abstinence has been achieved.

Authors+Show Affiliations

National Institute on Alcohol Abuse and Alcoholism Bethesda, Maryland 20892-1610, USA. Umhau@nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11371728

Citation

Umhau, J C., et al. "Hypothalamic Function in Response to 2-deoxy-D-glucose in Long-term Abstinent Alcoholics." Alcoholism, Clinical and Experimental Research, vol. 25, no. 5, 2001, pp. 781-6.
Umhau JC, Petrulis SG, Diaz R, et al. Hypothalamic function in response to 2-deoxy-D-glucose in long-term abstinent alcoholics. Alcohol Clin Exp Res. 2001;25(5):781-6.
Umhau, J. C., Petrulis, S. G., Diaz, R., Biddison, J. R., & George, A. D. (2001). Hypothalamic function in response to 2-deoxy-D-glucose in long-term abstinent alcoholics. Alcoholism, Clinical and Experimental Research, 25(5), 781-6.
Umhau JC, et al. Hypothalamic Function in Response to 2-deoxy-D-glucose in Long-term Abstinent Alcoholics. Alcohol Clin Exp Res. 2001;25(5):781-6. PubMed PMID: 11371728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypothalamic function in response to 2-deoxy-D-glucose in long-term abstinent alcoholics. AU - Umhau,J C, AU - Petrulis,S G, AU - Diaz,R, AU - Biddison,J R, AU - George,A D, PY - 2001/5/24/pubmed PY - 2001/8/10/medline PY - 2001/5/24/entrez SP - 781 EP - 6 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 25 IS - 5 N2 - BACKGROUND: The body adapts to diverse stressful stimuli with a response characterized by activation of the hypothalamic-pituitary-adrenal (HPA) axis. Chronic alcohol consumption can cause changes in the function of this neuroendocrine system. Although many studies have examined this phenomenon in drinking and recently sober alcoholics, few studies have examined HPA axis function in long-term sober alcoholics. METHODS: To characterize HPA axis function in long-term sober alcoholics, we used a challenge paradigm with 2-deoxy-d-glucose (2-DG). An infusion of 2-DG (a nonmetabolizable glucose analog) induces a well-characterized stress response. In a previous study, our laboratory found an exaggerated corticotropin and cortisol response in alcoholics abstinent 3 weeks; in this investigation we compared the effects of an infusion of 2-DG on 19 healthy volunteers and 20 community-living alcoholics who had been abstinent more than 6 months. RESULTS: In contrast to the previous study, long-term sober alcoholics did not have an exaggerated corticotropin and cortisol response after 2-DG. CONCLUSIONS: Previously observed abnormalities in cortisol regulation in 3-week-sober alcoholics may be related to the acute effects of recent alcohol consumption and withdrawal. Future investigations into the metabolic function of alcoholics, particularly investigations involving the HPA system, should consider the possibility that normalization may not occur until long-term abstinence has been achieved. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/11371728/Hypothalamic_function_in_response_to_2_deoxy_D_glucose_in_long_term_abstinent_alcoholics_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11371728.ui DB - PRIME DP - Unbound Medicine ER -