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An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine.
J Infect Dis. 2001 Jun 15; 183(12):1775-80.JI

Abstract

To evaluate the effectiveness of Vi polysaccharide vaccine (Vi vaccine) in preventing typhoid fever, an analysis was done of an outbreak of typhoid fever among students attending a middle school in the People's Republic of China, where Vi vaccine is licensed for use. Vi vaccine effectiveness was analyzed by using Cox proportional hazards modeling to account for the time-dependent nature of vaccination and illness status during the outbreak. Among 1260 students who had been immunized before the outbreak, receipt of Vi vaccine was associated with 73% (95% confidence interval [CI], 32%-89%) protection. Among the additional 441 students immunized during the outbreak, receipt of Vi vaccine was associated with 71% (95% CI, -9% to 92%) protection. These results provide the first evidence about the effectiveness of Vi vaccine when deployed routinely in a typhoid-endemic area and support the use of Vi vaccine as a public health tool to control typhoid fever.

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Authors+Show Affiliations

Yang HH
Guangxi Health and Anti-Epidemic Center, Guangxi Zhuang Autonomous Region, People's Republic of China.
Kilgore PE
No affiliation info available
Yang LH
No affiliation info available
Park JK
No affiliation info available
Pan YF
No affiliation info available
Kim Y
No affiliation info available
Lee YJ
No affiliation info available
Xu ZY
No affiliation info available
Clemens JD
No affiliation info available

MeSH

AdolescentAdultChildChinaDisease OutbreaksFemaleHumansMalePolysaccharides, BacterialProportional Hazards ModelsSalmonella typhiTime FactorsTreatment OutcomeTyphoid FeverTyphoid-Paratyphoid VaccinesVaccination

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11372030

Citation

Yang, H H., et al. "An Outbreak of Typhoid Fever, Xing-An County, People's Republic of China, 1999: Estimation of the Field Effectiveness of Vi Polysaccharide Typhoid Vaccine." The Journal of Infectious Diseases, vol. 183, no. 12, 2001, pp. 1775-80.
Yang HH, Kilgore PE, Yang LH, et al. An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. J Infect Dis. 2001;183(12):1775-80.
Yang, H. H., Kilgore, P. E., Yang, L. H., Park, J. K., Pan, Y. F., Kim, Y., Lee, Y. J., Xu, Z. Y., & Clemens, J. D. (2001). An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. The Journal of Infectious Diseases, 183(12), 1775-80.
Yang HH, et al. An Outbreak of Typhoid Fever, Xing-An County, People's Republic of China, 1999: Estimation of the Field Effectiveness of Vi Polysaccharide Typhoid Vaccine. J Infect Dis. 2001 Jun 15;183(12):1775-80. PubMed PMID: 11372030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. AU - Yang,H H, AU - Kilgore,P E, AU - Yang,L H, AU - Park,J K, AU - Pan,Y F, AU - Kim,Y, AU - Lee,Y J, AU - Xu,Z Y, AU - Clemens,J D, Y1 - 2001/05/17/ PY - 2000/12/05/received PY - 2001/03/05/revised PY - 2001/5/24/pubmed PY - 2001/7/13/medline PY - 2001/5/24/entrez SP - 1775 EP - 80 JF - The Journal of infectious diseases JO - J Infect Dis VL - 183 IS - 12 N2 - To evaluate the effectiveness of Vi polysaccharide vaccine (Vi vaccine) in preventing typhoid fever, an analysis was done of an outbreak of typhoid fever among students attending a middle school in the People's Republic of China, where Vi vaccine is licensed for use. Vi vaccine effectiveness was analyzed by using Cox proportional hazards modeling to account for the time-dependent nature of vaccination and illness status during the outbreak. Among 1260 students who had been immunized before the outbreak, receipt of Vi vaccine was associated with 73% (95% confidence interval [CI], 32%-89%) protection. Among the additional 441 students immunized during the outbreak, receipt of Vi vaccine was associated with 71% (95% CI, -9% to 92%) protection. These results provide the first evidence about the effectiveness of Vi vaccine when deployed routinely in a typhoid-endemic area and support the use of Vi vaccine as a public health tool to control typhoid fever. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11372030/An_outbreak_of_typhoid_fever_Xing_An_County_People's_Republic_of_China_1999:_estimation_of_the_field_effectiveness_of_Vi_polysaccharide_typhoid_vaccine_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/320729 DB - PRIME DP - Unbound Medicine ER -