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[Study on the relationships between leptin levels and weights of mothers and infants and the relationships of cord serum leptin to C-peptide, insulin and insulin like growth factor-II].
Zhonghua Fu Chan Ke Za Zhi. 2000 Oct; 35(10):603-5.ZF

Abstract

OBJECTIVE

To determine the relationships between serum leptin levels and maternal weights in late pregnancy and cord blood leptin levels to birth-weights, C-peptide, insulin and insulin like growth factor (IGF-II).

METHODS

Fifty normal pregnant women at 37-38 weeks and their newborns were studied, and 29 non-pregnant women were set as control. Venous blood was taken from women and from the cord at delivery. Blood leptin and cord blood C-peptide, insulin, and IGF-II were measured by radio-immunoassay.

RESULTS

The average leptin level in maternal sera was (13.62 +/- 3.68) micrograms/L, significantly higher than that in the control (6.60 +/- 3.04) micrograms/L and that in cord blood (8.05 +/- 4.61) micrograms/L. Maternal leptin levels were significantly correlated with maternal weights and body mass index (BMI. r = 0.33, 0.35, P < 0.05), but not with infant birth-weights (r = 0.10, P > 0.05). Cord blood leptin levels were significantly correlated with birth-weights and BMI (r = 0.54, 0.49, P < 0.001) but have no correlation with maternal leptin levels (r = 0.19, P > 0.05). Significant difference of the cord leptin levels was not seen between the males and females. The cord blood C-peptide was (0.86 +/- 0.35) microgram/L, insulin (8.49 +/- 4.76) mU/L and IGF-II (0.218 +/- 0.076) microgram/T. Cord leptin levels were correlated with C-peptide levels (r = 0.37, P < 0.05), but not with insulin and IGF-II levels (r = 0.19, -0.14, P > 0.05).

CONCLUSIONS

Maternal leptin levels in late pregnancy were significantly higher than those in normal non-pregnant women and positively correlated with maternal weights and BMI. Cord blood leptin levels were positively correlated with birth-weights and BMI of the newborns. The leptin levels of cord blood were correlated with those of C-peptide but not insulin and IGF-II.

Authors+Show Affiliations

General Hospital of the People's Liberation Army, Beijing 100853, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11372411

Citation

Lu, Y, et al. "[Study On the Relationships Between Leptin Levels and Weights of Mothers and Infants and the Relationships of Cord Serum Leptin to C-peptide, Insulin and Insulin Like Growth Factor-II]." Zhonghua Fu Chan Ke Za Zhi, vol. 35, no. 10, 2000, pp. 603-5.
Lu Y, Hao X, Weng X. [Study on the relationships between leptin levels and weights of mothers and infants and the relationships of cord serum leptin to C-peptide, insulin and insulin like growth factor-II]. Zhonghua Fu Chan Ke Za Zhi. 2000;35(10):603-5.
Lu, Y., Hao, X., & Weng, X. (2000). [Study on the relationships between leptin levels and weights of mothers and infants and the relationships of cord serum leptin to C-peptide, insulin and insulin like growth factor-II]. Zhonghua Fu Chan Ke Za Zhi, 35(10), 603-5.
Lu Y, Hao X, Weng X. [Study On the Relationships Between Leptin Levels and Weights of Mothers and Infants and the Relationships of Cord Serum Leptin to C-peptide, Insulin and Insulin Like Growth Factor-II]. Zhonghua Fu Chan Ke Za Zhi. 2000;35(10):603-5. PubMed PMID: 11372411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the relationships between leptin levels and weights of mothers and infants and the relationships of cord serum leptin to C-peptide, insulin and insulin like growth factor-II]. AU - Lu,Y, AU - Hao,X, AU - Weng,X, PY - 2001/5/25/pubmed PY - 2002/10/3/medline PY - 2001/5/25/entrez SP - 603 EP - 5 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 35 IS - 10 N2 - OBJECTIVE: To determine the relationships between serum leptin levels and maternal weights in late pregnancy and cord blood leptin levels to birth-weights, C-peptide, insulin and insulin like growth factor (IGF-II). METHODS: Fifty normal pregnant women at 37-38 weeks and their newborns were studied, and 29 non-pregnant women were set as control. Venous blood was taken from women and from the cord at delivery. Blood leptin and cord blood C-peptide, insulin, and IGF-II were measured by radio-immunoassay. RESULTS: The average leptin level in maternal sera was (13.62 +/- 3.68) micrograms/L, significantly higher than that in the control (6.60 +/- 3.04) micrograms/L and that in cord blood (8.05 +/- 4.61) micrograms/L. Maternal leptin levels were significantly correlated with maternal weights and body mass index (BMI. r = 0.33, 0.35, P < 0.05), but not with infant birth-weights (r = 0.10, P > 0.05). Cord blood leptin levels were significantly correlated with birth-weights and BMI (r = 0.54, 0.49, P < 0.001) but have no correlation with maternal leptin levels (r = 0.19, P > 0.05). Significant difference of the cord leptin levels was not seen between the males and females. The cord blood C-peptide was (0.86 +/- 0.35) microgram/L, insulin (8.49 +/- 4.76) mU/L and IGF-II (0.218 +/- 0.076) microgram/T. Cord leptin levels were correlated with C-peptide levels (r = 0.37, P < 0.05), but not with insulin and IGF-II levels (r = 0.19, -0.14, P > 0.05). CONCLUSIONS: Maternal leptin levels in late pregnancy were significantly higher than those in normal non-pregnant women and positively correlated with maternal weights and BMI. Cord blood leptin levels were positively correlated with birth-weights and BMI of the newborns. The leptin levels of cord blood were correlated with those of C-peptide but not insulin and IGF-II. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/11372411/[Study_on_the_relationships_between_leptin_levels_and_weights_of_mothers_and_infants_and_the_relationships_of_cord_serum_leptin_to_C_peptide_insulin_and_insulin_like_growth_factor_II]_ L2 - http://www.diseaseinfosearch.org/result/2708 DB - PRIME DP - Unbound Medicine ER -