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Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia?
Am J Gastroenterol. 2001 May; 96(5):1422-8.AJ

Abstract

OBJECTIVE

Different subgroups can be identified in functional dyspepsia based on symptom type or severity, and may correlate with pathophysiological disturbances. In particular, female sex and severe fullness and vomiting have been reported to be strong independent predictors of slow solid gastric emptying. We aimed to determine if symptom patterns or severity could identify those with abnormal gastric emptying among patients with dysmotility-like functional dyspepsia and, for comparison, type I diabetes mellitus.

METHODS

Patients with postprandial symptoms and documented functional dyspepsia by endoscopy (n = 551) and patients with type I diabetes who had postprandial dyspepsia (n = 247) enrolling in two separate randomized controlled trials were evaluated at baseline. Patients were assigned to either the delayed or normal gastric emptying strata, based on a validated C13 octanoic acid breath test with sampling over 4 h. A self-report questionnaire measured the presence and severity of eight symptoms on visual analog scales. The validated Nepean Dyspepsia Index measured the frequency, severity, and bothersomeness of 15 upper GI symptoms on Likert scales.

RESULTS

Gastric emptying was definitely delayed (t1/2 > 192 min) in 24% of patients with functional dyspepsia and 28% with diabetes. Delayed gastric emptying was associated with female gender but not age or Helicobacter pylori status. The age- and sex-adjusted risk (odds ratio) of delayed gastric emptying for the upper GI symptoms ranged from 0.99 to 1.0 (all p values > or =0.2). The results were very similar in functional dyspepsia and diabetes. There was also no correlation between t1/2 and number of symptoms or symptom severity scores.

CONCLUSIONS

Symptom prevalence and severity were similar in dyspeptic patients with and without delayed gastric emptying. Specific symptoms do not seem to be of predictive value in dysmotility-like dyspepsia for identifying alterations of gastric emptying.

Authors+Show Affiliations

Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11374677

Citation

Talley, N J., et al. "Can Symptoms Discriminate Among Those With Delayed or Normal Gastric Emptying in Dysmotility-like Dyspepsia?" The American Journal of Gastroenterology, vol. 96, no. 5, 2001, pp. 1422-8.
Talley NJ, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? Am J Gastroenterol. 2001;96(5):1422-8.
Talley, N. J., Verlinden, M., & Jones, M. (2001). Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? The American Journal of Gastroenterology, 96(5), 1422-8.
Talley NJ, Verlinden M, Jones M. Can Symptoms Discriminate Among Those With Delayed or Normal Gastric Emptying in Dysmotility-like Dyspepsia. Am J Gastroenterol. 2001;96(5):1422-8. PubMed PMID: 11374677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? AU - Talley,N J, AU - Verlinden,M, AU - Jones,M, PY - 2001/5/26/pubmed PY - 2001/6/29/medline PY - 2001/5/26/entrez SP - 1422 EP - 8 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 96 IS - 5 N2 - OBJECTIVE: Different subgroups can be identified in functional dyspepsia based on symptom type or severity, and may correlate with pathophysiological disturbances. In particular, female sex and severe fullness and vomiting have been reported to be strong independent predictors of slow solid gastric emptying. We aimed to determine if symptom patterns or severity could identify those with abnormal gastric emptying among patients with dysmotility-like functional dyspepsia and, for comparison, type I diabetes mellitus. METHODS: Patients with postprandial symptoms and documented functional dyspepsia by endoscopy (n = 551) and patients with type I diabetes who had postprandial dyspepsia (n = 247) enrolling in two separate randomized controlled trials were evaluated at baseline. Patients were assigned to either the delayed or normal gastric emptying strata, based on a validated C13 octanoic acid breath test with sampling over 4 h. A self-report questionnaire measured the presence and severity of eight symptoms on visual analog scales. The validated Nepean Dyspepsia Index measured the frequency, severity, and bothersomeness of 15 upper GI symptoms on Likert scales. RESULTS: Gastric emptying was definitely delayed (t1/2 > 192 min) in 24% of patients with functional dyspepsia and 28% with diabetes. Delayed gastric emptying was associated with female gender but not age or Helicobacter pylori status. The age- and sex-adjusted risk (odds ratio) of delayed gastric emptying for the upper GI symptoms ranged from 0.99 to 1.0 (all p values > or =0.2). The results were very similar in functional dyspepsia and diabetes. There was also no correlation between t1/2 and number of symptoms or symptom severity scores. CONCLUSIONS: Symptom prevalence and severity were similar in dyspeptic patients with and without delayed gastric emptying. Specific symptoms do not seem to be of predictive value in dysmotility-like dyspepsia for identifying alterations of gastric emptying. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11374677/Can_symptoms_discriminate_among_those_with_delayed_or_normal_gastric_emptying_in_dysmotility_like_dyspepsia L2 - https://doi.org/10.1111/j.1572-0241.2001.03683.x DB - PRIME DP - Unbound Medicine ER -