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Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease.
Diabetes Res Clin Pract. 2001 Jul; 53(1):33-9.DR

Abstract

Lipid peroxides are thought to be formed by free radicals and may play an important role in the development of atheromatous vascular diseases. The relationship between serum lipids, lipoproteins, lipid peroxides [thiobarbituric acid reactive substances (TBARS)] and erythrocyte antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD)] was investigated in non-insulin-dependent diabetic patients with and without coronary heart disease (CHD), and a comparison was made for all the above parameters with non-diabetic patients with CHD. Lipid peroxide concentrations were significantly increased in both groups of diabetic patients and also in non-diabetic patients with CHD, compared to those in control subjects. Diabetic patients with CHD had higher levels of TBARS compared to those diabetics without CHD. Hyperlipidaemia and abnormal lipoprotein levels were observed in all three groups of patients. Increased total cholesterol and LDL-cholesterol were observed in diabetics with CHD compared to those without CHD. Among the erythrocyte antioxidant enzymes, CAT activity was increased, GPx activity was decreased and no change was observed in SOD activity in both groups of diabetic patients and non-diabetic patients with CHD compared to those in controls. A clear correlation was observed between the CAT activity and lipid peroxide concentrations in all the diabetic patients. These observations suggest that there are similar abnormalities in lipid metabolism and erythrocyte antioxidant enzymes in diabetic patients and non-diabetic patients with CHD.

Authors+Show Affiliations

Department of Biochemistry, School of Biological and Earth Sciences, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11378211

Citation

Kesavulu, M M., et al. "Lipid Peroxidation and Antioxidant Enzyme Status in Type 2 Diabetics With Coronary Heart Disease." Diabetes Research and Clinical Practice, vol. 53, no. 1, 2001, pp. 33-9.
Kesavulu MM, Rao BK, Giri R, et al. Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. Diabetes Res Clin Pract. 2001;53(1):33-9.
Kesavulu, M. M., Rao, B. K., Giri, R., Vijaya, J., Subramanyam, G., & Apparao, C. (2001). Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. Diabetes Research and Clinical Practice, 53(1), 33-9.
Kesavulu MM, et al. Lipid Peroxidation and Antioxidant Enzyme Status in Type 2 Diabetics With Coronary Heart Disease. Diabetes Res Clin Pract. 2001;53(1):33-9. PubMed PMID: 11378211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. AU - Kesavulu,M M, AU - Rao,B K, AU - Giri,R, AU - Vijaya,J, AU - Subramanyam,G, AU - Apparao,C, PY - 2001/5/30/pubmed PY - 2001/7/6/medline PY - 2001/5/30/entrez SP - 33 EP - 9 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 53 IS - 1 N2 - Lipid peroxides are thought to be formed by free radicals and may play an important role in the development of atheromatous vascular diseases. The relationship between serum lipids, lipoproteins, lipid peroxides [thiobarbituric acid reactive substances (TBARS)] and erythrocyte antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD)] was investigated in non-insulin-dependent diabetic patients with and without coronary heart disease (CHD), and a comparison was made for all the above parameters with non-diabetic patients with CHD. Lipid peroxide concentrations were significantly increased in both groups of diabetic patients and also in non-diabetic patients with CHD, compared to those in control subjects. Diabetic patients with CHD had higher levels of TBARS compared to those diabetics without CHD. Hyperlipidaemia and abnormal lipoprotein levels were observed in all three groups of patients. Increased total cholesterol and LDL-cholesterol were observed in diabetics with CHD compared to those without CHD. Among the erythrocyte antioxidant enzymes, CAT activity was increased, GPx activity was decreased and no change was observed in SOD activity in both groups of diabetic patients and non-diabetic patients with CHD compared to those in controls. A clear correlation was observed between the CAT activity and lipid peroxide concentrations in all the diabetic patients. These observations suggest that there are similar abnormalities in lipid metabolism and erythrocyte antioxidant enzymes in diabetic patients and non-diabetic patients with CHD. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/11378211/Lipid_peroxidation_and_antioxidant_enzyme_status_in_Type_2_diabetics_with_coronary_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168822701002388 DB - PRIME DP - Unbound Medicine ER -