Tags

Type your tag names separated by a space and hit enter

Circadian rhythm and postural change in natriuresis in non-dipper type of essential hypertension.
J Hum Hypertens. 2001 May; 15(5):323-7.JH

Abstract

Recently we found that, in non-dipper type of essential hypertensive patients who showed the lack of nocturnal fall in blood pressure, circadian rhythm of urinary sodium excretion rate was disturbed. In the present study we examined whether postural change in natriuresis is also disturbed in non-dippers. Sixteen inpatients with essential hypertension were maintained on a relatively high sodium diet containing 10 to 12 g of NaCl per day for 8 days. On the 7th day of the study period, 24-h ambulatory blood pressures were measured, and 5-7th days urinary samples were collected for both daytime and night-time. On the last day of the study period, patients stood for 2 h and then lay down for 2 h. Urinary volume and excretion rates of creatinine and sodium were measured every hour in both positions. Night-time urinary sodium excretion rate was significantly higher in non-dippers (n = 9) than that in dippers (n = 7). Night/day ratio of mean arterial pressure had a positive relationship with night/day ratio of urinary sodium excretion rate. In non-dippers, but not in dippers, the mean value of U(Na)V during upright position was significantly lower than that during supine position. There was a significantly negative relationship between upright/supine ratio of U(Na)V and night/day ratio of MAP or night/day ratio of U(Na)V. In patients with non-dipper type of essential hypertension, both natriuresis patterns, circadian rhythm and postural change, were disturbed.

Authors+Show Affiliations

Division of Nephrology, Osaka Rosai Hospital, Osaka 591-8025, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11378834

Citation

Uzu, T, et al. "Circadian Rhythm and Postural Change in Natriuresis in Non-dipper Type of Essential Hypertension." Journal of Human Hypertension, vol. 15, no. 5, 2001, pp. 323-7.
Uzu T, Takeji M, Yamauchi A, et al. Circadian rhythm and postural change in natriuresis in non-dipper type of essential hypertension. J Hum Hypertens. 2001;15(5):323-7.
Uzu, T., Takeji, M., Yamauchi, A., & Kimura, G. (2001). Circadian rhythm and postural change in natriuresis in non-dipper type of essential hypertension. Journal of Human Hypertension, 15(5), 323-7.
Uzu T, et al. Circadian Rhythm and Postural Change in Natriuresis in Non-dipper Type of Essential Hypertension. J Hum Hypertens. 2001;15(5):323-7. PubMed PMID: 11378834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian rhythm and postural change in natriuresis in non-dipper type of essential hypertension. AU - Uzu,T, AU - Takeji,M, AU - Yamauchi,A, AU - Kimura,G, PY - 2000/09/28/received PY - 2000/12/10/revised PY - 2000/12/11/accepted PY - 2001/5/30/pubmed PY - 2001/7/28/medline PY - 2001/5/30/entrez SP - 323 EP - 7 JF - Journal of human hypertension JO - J Hum Hypertens VL - 15 IS - 5 N2 - Recently we found that, in non-dipper type of essential hypertensive patients who showed the lack of nocturnal fall in blood pressure, circadian rhythm of urinary sodium excretion rate was disturbed. In the present study we examined whether postural change in natriuresis is also disturbed in non-dippers. Sixteen inpatients with essential hypertension were maintained on a relatively high sodium diet containing 10 to 12 g of NaCl per day for 8 days. On the 7th day of the study period, 24-h ambulatory blood pressures were measured, and 5-7th days urinary samples were collected for both daytime and night-time. On the last day of the study period, patients stood for 2 h and then lay down for 2 h. Urinary volume and excretion rates of creatinine and sodium were measured every hour in both positions. Night-time urinary sodium excretion rate was significantly higher in non-dippers (n = 9) than that in dippers (n = 7). Night/day ratio of mean arterial pressure had a positive relationship with night/day ratio of urinary sodium excretion rate. In non-dippers, but not in dippers, the mean value of U(Na)V during upright position was significantly lower than that during supine position. There was a significantly negative relationship between upright/supine ratio of U(Na)V and night/day ratio of MAP or night/day ratio of U(Na)V. In patients with non-dipper type of essential hypertension, both natriuresis patterns, circadian rhythm and postural change, were disturbed. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/11378834/Circadian_rhythm_and_postural_change_in_natriuresis_in_non_dipper_type_of_essential_hypertension_ L2 - https://doi.org/10.1038/sj.jhh.1001185 DB - PRIME DP - Unbound Medicine ER -