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A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers.

Abstract

In view of the reports that phenytoin and honey are useful in the healing of wounds, a comparison of their topical use in the treatment of chronic leg ulcers was carried out. Fifty cases of chronic leg ulceration were studied, each for a period of four weeks. They were assigned into three groups for honey, phenytoin/honey mixture, and phenytoin topical treatment. Overall mean duration of the ulcers was 56.5 months while the mean(s.d.) size was 3339 (5193) mm2. Mean percent reduction in size in the group treated with honey, 27.0 (36.9), was not significantly different (H = 0.26; 2 df; p = 0.88) from that of the mixture group, which was 25.9 (46.4), and from that of the phenytoin group which was 35.5 (53.2). This percent reduction in size was significantly greater, (H = 7.69; 2 df; P = 0.02), during the first week in the phenytoin group than in the other groups. Four of the cases progressed to complete healing at the end of four weeks with phenytoin. Pain score difference (using a graduation scale from 0 to 10) at the end of the four week treatment, was, 1.8 (1.7) in honey group, 2.0 (1.3) in mixture group and 3.6 (2.4) in phenytoin group. This difference was not significant, (H = 3.09; 2 df; P = 0.21). Our study suggests that phenytoin may be superior to honey as a topical agent in the treatment of chronic ulcers.

Authors+Show Affiliations

,

Department of Surgery, University College Hospital, Ibadan, Nigeria.

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Source

MeSH

Administration, Cutaneous
Adolescent
Adult
Aged
Aged, 80 and over
Child
Chronic Disease
Drug Combinations
Female
Honey
Humans
Leg Ulcer
Male
Middle Aged
Pain
Pain Measurement
Phenytoin
Severity of Illness Index
Time Factors
Treatment Outcome
Wound Healing

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11379464

Citation

Oluwatosin, O M., et al. "A Comparison of Topical Honey and Phenytoin in the Treatment of Chronic Leg Ulcers." African Journal of Medicine and Medical Sciences, vol. 29, no. 1, 2000, pp. 31-4.
Oluwatosin OM, Olabanji JK, Oluwatosin OA, et al. A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. Afr J Med Med Sci. 2000;29(1):31-4.
Oluwatosin, O. M., Olabanji, J. K., Oluwatosin, O. A., Tijani, L. A., & Onyechi, H. U. (2000). A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. African Journal of Medicine and Medical Sciences, 29(1), pp. 31-4.
Oluwatosin OM, et al. A Comparison of Topical Honey and Phenytoin in the Treatment of Chronic Leg Ulcers. Afr J Med Med Sci. 2000;29(1):31-4. PubMed PMID: 11379464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of topical honey and phenytoin in the treatment of chronic leg ulcers. AU - Oluwatosin,O M, AU - Olabanji,J K, AU - Oluwatosin,O A, AU - Tijani,L A, AU - Onyechi,H U, PY - 2001/5/31/pubmed PY - 2001/6/29/medline PY - 2001/5/31/entrez SP - 31 EP - 4 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 29 IS - 1 N2 - In view of the reports that phenytoin and honey are useful in the healing of wounds, a comparison of their topical use in the treatment of chronic leg ulcers was carried out. Fifty cases of chronic leg ulceration were studied, each for a period of four weeks. They were assigned into three groups for honey, phenytoin/honey mixture, and phenytoin topical treatment. Overall mean duration of the ulcers was 56.5 months while the mean(s.d.) size was 3339 (5193) mm2. Mean percent reduction in size in the group treated with honey, 27.0 (36.9), was not significantly different (H = 0.26; 2 df; p = 0.88) from that of the mixture group, which was 25.9 (46.4), and from that of the phenytoin group which was 35.5 (53.2). This percent reduction in size was significantly greater, (H = 7.69; 2 df; P = 0.02), during the first week in the phenytoin group than in the other groups. Four of the cases progressed to complete healing at the end of four weeks with phenytoin. Pain score difference (using a graduation scale from 0 to 10) at the end of the four week treatment, was, 1.8 (1.7) in honey group, 2.0 (1.3) in mixture group and 3.6 (2.4) in phenytoin group. This difference was not significant, (H = 3.09; 2 df; P = 0.21). Our study suggests that phenytoin may be superior to honey as a topical agent in the treatment of chronic ulcers. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/11379464/A_comparison_of_topical_honey_and_phenytoin_in_the_treatment_of_chronic_leg_ulcers_ L2 - https://medlineplus.gov/leginjuriesanddisorders.html DB - PRIME DP - Unbound Medicine ER -