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Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis.
Contact Dermatitis. 2001 Jun; 44(6):337-43.CD

Abstract

In experimentally-induced irritant (ICD) and allergic (ACD) contact dermatitis, an oil-in-water (o/w) cream was applied to investigate its effects on a disturbed barrier function compared to untreated physiological barrier repair. Transepidermal water loss (TEWL) measurements were performed. Before the start of the experiments, the skin tolerance of the cream was examined, revealing the non-irritating characteristics of the ingredients and the absence of any contact allergic patch test reaction. In the ICD study, sodium lauryl sulfate (SLS) patches were applied to the forearms of young female volunteers. Consequently, it was observed that repeated cream application (14 days, 2x/day) significantly improved the TEWL of SLS-damaged skin, leading to a complete recovery on day 15. In the ACD study, disruption of skin barrier function was obtained by a nickel-mediated contact allergy patch (CAP) test. The cream was then applied 2x/day for 4 consecutive days. Assessment of TEWL clearly showed that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair.

Authors+Show Affiliations

Department of Toxicology, Vrije Universiteit Brussel, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11380543

Citation

De Paépe, K, et al. "Beneficial Effects of a Skin Tolerance-tested Moisturizing Cream On the Barrier Function in Experimentally-elicited Irritant and Allergic Contact Dermatitis." Contact Dermatitis, vol. 44, no. 6, 2001, pp. 337-43.
De Paépe K, Hachem JP, Vanpee E, et al. Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis. Contact Dermatitis. 2001;44(6):337-43.
De Paépe, K., Hachem, J. P., Vanpee, E., Goossens, A., Germaux, M. A., Lachapelle, J. M., Lambert, J., Matthieu, L., Roseeuw, D., Suys, E., Van Hecke, E., & Rogiers, V. (2001). Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis. Contact Dermatitis, 44(6), 337-43.
De Paépe K, et al. Beneficial Effects of a Skin Tolerance-tested Moisturizing Cream On the Barrier Function in Experimentally-elicited Irritant and Allergic Contact Dermatitis. Contact Dermatitis. 2001;44(6):337-43. PubMed PMID: 11380543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis. AU - De Paépe,K, AU - Hachem,J P, AU - Vanpee,E, AU - Goossens,A, AU - Germaux,M A, AU - Lachapelle,J M, AU - Lambert,J, AU - Matthieu,L, AU - Roseeuw,D, AU - Suys,E, AU - Van Hecke,E, AU - Rogiers,V, PY - 2001/6/21/pubmed PY - 2001/7/20/medline PY - 2001/6/21/entrez SP - 337 EP - 43 JF - Contact dermatitis JO - Contact Dermatitis VL - 44 IS - 6 N2 - In experimentally-induced irritant (ICD) and allergic (ACD) contact dermatitis, an oil-in-water (o/w) cream was applied to investigate its effects on a disturbed barrier function compared to untreated physiological barrier repair. Transepidermal water loss (TEWL) measurements were performed. Before the start of the experiments, the skin tolerance of the cream was examined, revealing the non-irritating characteristics of the ingredients and the absence of any contact allergic patch test reaction. In the ICD study, sodium lauryl sulfate (SLS) patches were applied to the forearms of young female volunteers. Consequently, it was observed that repeated cream application (14 days, 2x/day) significantly improved the TEWL of SLS-damaged skin, leading to a complete recovery on day 15. In the ACD study, disruption of skin barrier function was obtained by a nickel-mediated contact allergy patch (CAP) test. The cream was then applied 2x/day for 4 consecutive days. Assessment of TEWL clearly showed that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/11380543/Beneficial_effects_of_a_skin_tolerance_tested_moisturizing_cream_on_the_barrier_function_in_experimentally_elicited_irritant_and_allergic_contact_dermatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-1873&date=2001&volume=44&issue=6&spage=337 DB - PRIME DP - Unbound Medicine ER -