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Patterns of open-angle glaucoma in the Barbados Family Study.

Abstract

OBJECTIVE

To describe the Barbados Family Study of open-angle glaucoma (OAG) and present risk factors for OAG in siblings of study probands.

DESIGN

Observational study of families of probands with OAG.

PARTICIPANTS

Two hundred thirty probands and 1056 relatives (from 207 families).

METHODS

Probands and their family members underwent standardized examinations, including automated perimetry, applanation tonometry, ophthalmologic evaluation, fundus photography, blood pressure, interview, and genotyping. Generalized estimation equation methods were used to evaluate risk factors.

MAIN OUTCOME MEASURES

Presence of OAG in the relatives, as defined by both visual field and optic disc findings, after ophthalmologic exclusion of other causes.

RESULTS

The median ages of probands and relatives were 68 and 47 years, respectively. In the 207 families, 29% of the probands had one relative with OAG and 10% had two or more relatives affected. Of the 1056 family members, 10% had OAG, 13% had suspect OAG, and 6% had ocular hypertension. One fifth of the 338 siblings had OAG (n = 67); they tended to be older and more often were male. Multivariate comparisons between siblings with and without OAG found that age, higher intraocular pressure (IOP), myopia, and lower diastolic blood pressure-IOP differences were related to OAG, whereas hypertension and diabetes were not.

CONCLUSIONS

Based on standardized protocols and examinations, approximately one quarter of the relatives had OAG or suspected OAG, despite their relatively young age. Risk factors for OAG in siblings were similar to risk factors in unrelated individuals. Analyses are ongoing to determine OAG inheritance and to localize potential gene(s) involved.

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  • Authors+Show Affiliations

    ,

    School of Medicine, University Medical Center at Stony Brook, Stony Brook, New York 11794-8036, USA. cleske@uhmc.sunysb.edu

    , , , ,

    Source

    Ophthalmology 108:6 2001 Jun pg 1015-22

    MeSH

    Adult
    African Continental Ancestry Group
    Aged
    Aged, 80 and over
    Barbados
    Blood Pressure
    Family Health
    Female
    Glaucoma, Open-Angle
    Humans
    Intraocular Pressure
    Male
    Middle Aged
    Ocular Hypertension
    Optic Disk
    Pedigree
    Risk Factors
    Tonometry, Ocular
    Visual Field Tests
    Visual Fields

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11382622

    Citation

    Leske, M C., et al. "Patterns of Open-angle Glaucoma in the Barbados Family Study." Ophthalmology, vol. 108, no. 6, 2001, pp. 1015-22.
    Leske MC, Nemesure B, He Q, et al. Patterns of open-angle glaucoma in the Barbados Family Study. Ophthalmology. 2001;108(6):1015-22.
    Leske, M. C., Nemesure, B., He, Q., Wu, S. Y., Fielding Hejtmancik, J., & Hennis, A. (2001). Patterns of open-angle glaucoma in the Barbados Family Study. Ophthalmology, 108(6), pp. 1015-22.
    Leske MC, et al. Patterns of Open-angle Glaucoma in the Barbados Family Study. Ophthalmology. 2001;108(6):1015-22. PubMed PMID: 11382622.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Patterns of open-angle glaucoma in the Barbados Family Study. AU - Leske,M C, AU - Nemesure,B, AU - He,Q, AU - Wu,S Y, AU - Fielding Hejtmancik,J, AU - Hennis,A, PY - 2001/5/31/pubmed PY - 2001/6/22/medline PY - 2001/5/31/entrez SP - 1015 EP - 22 JF - Ophthalmology JO - Ophthalmology VL - 108 IS - 6 N2 - OBJECTIVE: To describe the Barbados Family Study of open-angle glaucoma (OAG) and present risk factors for OAG in siblings of study probands. DESIGN: Observational study of families of probands with OAG. PARTICIPANTS: Two hundred thirty probands and 1056 relatives (from 207 families). METHODS: Probands and their family members underwent standardized examinations, including automated perimetry, applanation tonometry, ophthalmologic evaluation, fundus photography, blood pressure, interview, and genotyping. Generalized estimation equation methods were used to evaluate risk factors. MAIN OUTCOME MEASURES: Presence of OAG in the relatives, as defined by both visual field and optic disc findings, after ophthalmologic exclusion of other causes. RESULTS: The median ages of probands and relatives were 68 and 47 years, respectively. In the 207 families, 29% of the probands had one relative with OAG and 10% had two or more relatives affected. Of the 1056 family members, 10% had OAG, 13% had suspect OAG, and 6% had ocular hypertension. One fifth of the 338 siblings had OAG (n = 67); they tended to be older and more often were male. Multivariate comparisons between siblings with and without OAG found that age, higher intraocular pressure (IOP), myopia, and lower diastolic blood pressure-IOP differences were related to OAG, whereas hypertension and diabetes were not. CONCLUSIONS: Based on standardized protocols and examinations, approximately one quarter of the relatives had OAG or suspected OAG, despite their relatively young age. Risk factors for OAG in siblings were similar to risk factors in unrelated individuals. Analyses are ongoing to determine OAG inheritance and to localize potential gene(s) involved. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/11382622/Patterns_of_open_angle_glaucoma_in_the_Barbados_Family_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161642001005668 DB - PRIME DP - Unbound Medicine ER -