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Sexually dimorphic effects of GHRH on sleep-endocrine activity in patients with depression and normal controls - part II: hormone secretion.
Sleep Res Online. 2000; 3(1):15-21.SR

Abstract

In depression and aging an increase in nocturnal cortisol secretion and a blunted nocturnal growth hormone (GH) surge have been described. In normal young men, growth hormone-releasing hormone (GHRH) promotes GH release and reduces plasma cortisol. Here, we examined whether GHRH could help to restore sleep-endocrine regulation in patients with depression and aging. GHRH (4x50 microgram, at 2200, 2300, 2400 and 0100 h) or saline (placebo) was injected intravenously to 42 patients with depression (19 females, 23 males) and matched controls (age range 19-76 years). Blood samples were withdrawn at 20 min intervals between 2200-0700 h and analysed using Manova (D.F. 1, 72). Patients compared to controls had significantly higher levels of ACTH and cortisol, particularly during the first half of the night (F=9 and F=11.8, each p<0.05). GHRH reduced ACTH during the first and cortisol secretion during the second half of the night in males, regardless of diagnosis, but enhanced it in females (F=5.1 and F=4.0, each p<0.05). ACTH and cortisol secretion were inversely related to NREM and stage 2 sleep in patients (r= -0.42, -0.42 and r= -0.36, -0.39, respectively, each p<0.05) but not in controls. Our data suggest that: 1) female gender, depression and aging add-on to enhance HPA activity, and 2) hyperactivity of the HPA system and the decrease in NREM and in particular stage 2 sleep in depression are interrelated. In men, GHRH can restore some of the sleep-endocrine alterations associated with depression and aging.

Authors+Show Affiliations

Max Planc Institute of Psychiatry, Department of Psychiatry, Munich D-80804, Germany. irina@mpipsykl.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11382895

Citation

Antonijevic, I A., et al. "Sexually Dimorphic Effects of GHRH On Sleep-endocrine Activity in Patients With Depression and Normal Controls - Part II: Hormone Secretion." Sleep Research Online : SRO, vol. 3, no. 1, 2000, pp. 15-21.
Antonijevic IA, Murck H, Frieboes RM, et al. Sexually dimorphic effects of GHRH on sleep-endocrine activity in patients with depression and normal controls - part II: hormone secretion. Sleep Res Online. 2000;3(1):15-21.
Antonijevic, I. A., Murck, H., Frieboes, R. M., & Steiger, A. (2000). Sexually dimorphic effects of GHRH on sleep-endocrine activity in patients with depression and normal controls - part II: hormone secretion. Sleep Research Online : SRO, 3(1), 15-21.
Antonijevic IA, et al. Sexually Dimorphic Effects of GHRH On Sleep-endocrine Activity in Patients With Depression and Normal Controls - Part II: Hormone Secretion. Sleep Res Online. 2000;3(1):15-21. PubMed PMID: 11382895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sexually dimorphic effects of GHRH on sleep-endocrine activity in patients with depression and normal controls - part II: hormone secretion. AU - Antonijevic,I A, AU - Murck,H, AU - Frieboes,R M, AU - Steiger,A, PY - 2001/5/31/pubmed PY - 2002/1/5/medline PY - 2001/5/31/entrez SP - 15 EP - 21 JF - Sleep research online : SRO JO - Sleep Res Online VL - 3 IS - 1 N2 - In depression and aging an increase in nocturnal cortisol secretion and a blunted nocturnal growth hormone (GH) surge have been described. In normal young men, growth hormone-releasing hormone (GHRH) promotes GH release and reduces plasma cortisol. Here, we examined whether GHRH could help to restore sleep-endocrine regulation in patients with depression and aging. GHRH (4x50 microgram, at 2200, 2300, 2400 and 0100 h) or saline (placebo) was injected intravenously to 42 patients with depression (19 females, 23 males) and matched controls (age range 19-76 years). Blood samples were withdrawn at 20 min intervals between 2200-0700 h and analysed using Manova (D.F. 1, 72). Patients compared to controls had significantly higher levels of ACTH and cortisol, particularly during the first half of the night (F=9 and F=11.8, each p<0.05). GHRH reduced ACTH during the first and cortisol secretion during the second half of the night in males, regardless of diagnosis, but enhanced it in females (F=5.1 and F=4.0, each p<0.05). ACTH and cortisol secretion were inversely related to NREM and stage 2 sleep in patients (r= -0.42, -0.42 and r= -0.36, -0.39, respectively, each p<0.05) but not in controls. Our data suggest that: 1) female gender, depression and aging add-on to enhance HPA activity, and 2) hyperactivity of the HPA system and the decrease in NREM and in particular stage 2 sleep in depression are interrelated. In men, GHRH can restore some of the sleep-endocrine alterations associated with depression and aging. SN - 1096-214X UR - https://www.unboundmedicine.com/medline/citation/11382895/Sexually_dimorphic_effects_of_GHRH_on_sleep_endocrine_activity_in_patients_with_depression_and_normal_controls___part_II:_hormone_secretion_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -