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Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances.
Wien Klin Wochenschr. 2001 Apr 17; 113(7-8):249-53.WK

Abstract

STUDY OBJECTIVE

To assess the frequency of rapid eye movement (REM) sleep abnormalities in Parkinson's disease (PD) patients and compare polygraphic sleep measures in those with and without REM sleep disturbances.

DESIGN

Polysomnographic recordings of 2 consecutive nights were performed in 45 patients with PD (mean age 65 years, mean Hoehn and Yahr stage 2.2). Twenty patients were treated with dopaminergic drugs, 10 were drug-free for two weeks and 15 had never been treated with L-dopa or dopamine agonists. According to the polysomnographic findings, the patients were divided into those with and without REM sleep abnormalities. Abnormal REM sleep features were defined as REM sleep without atonia (RWA) and REM sleep behavior disorder (RBD).

RESULTS

Eighteen (40%) of the PD patients showed either RWA (24%; 6 men, 5 women) or RBD (16%; 6 men, 1 woman). Patients with REM sleep disturbances had a significantly longer duration of the disease (8.3 vs. 3.9 years), a more severe stage of the disease (2.6 vs. 2.0 Hoehn and Yahr stage) and were treated with a higher dosage of dopaminergic drugs (L-dopa, pergolide and bromocriptin). 67% of the patients with normal REM sleep were untreated at the time of the sleep study, but only 39% of those with REM sleep abnormalities. Sleep EEG measures (sleep efficiency, sleep onset latency, sleep period time, relative amounts of sleep stages) for the second night showed no significant differences between both groups apart from a significantly lower sleep period time in PD patients with RWA/RBD.

CONCLUSIONS

Abnormal REM sleep features are a frequent finding in patients with PD. The prevalence seems to increase with a longer disease duration. Therefore, a careful follow-up is necessary. A sleep architecture not different from PD patients without RWA/RBD suggests that the underlying abnormality is confined to REM sleep.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Munich, Federal Republic of Germany. wetter@mpipsyk1.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11383385

Citation

Wetter, T C., et al. "Polysomnographic Measures in Parkinson's Disease: a Comparison Between Patients With and Without REM Sleep Disturbances." Wiener Klinische Wochenschrift, vol. 113, no. 7-8, 2001, pp. 249-53.
Wetter TC, Trenkwalder C, Gershanik O, et al. Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances. Wien Klin Wochenschr. 2001;113(7-8):249-53.
Wetter, T. C., Trenkwalder, C., Gershanik, O., & Högl, B. (2001). Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances. Wiener Klinische Wochenschrift, 113(7-8), 249-53.
Wetter TC, et al. Polysomnographic Measures in Parkinson's Disease: a Comparison Between Patients With and Without REM Sleep Disturbances. Wien Klin Wochenschr. 2001 Apr 17;113(7-8):249-53. PubMed PMID: 11383385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances. AU - Wetter,T C, AU - Trenkwalder,C, AU - Gershanik,O, AU - Högl,B, PY - 2001/6/1/pubmed PY - 2001/7/13/medline PY - 2001/6/1/entrez SP - 249 EP - 53 JF - Wiener klinische Wochenschrift JO - Wien Klin Wochenschr VL - 113 IS - 7-8 N2 - STUDY OBJECTIVE: To assess the frequency of rapid eye movement (REM) sleep abnormalities in Parkinson's disease (PD) patients and compare polygraphic sleep measures in those with and without REM sleep disturbances. DESIGN: Polysomnographic recordings of 2 consecutive nights were performed in 45 patients with PD (mean age 65 years, mean Hoehn and Yahr stage 2.2). Twenty patients were treated with dopaminergic drugs, 10 were drug-free for two weeks and 15 had never been treated with L-dopa or dopamine agonists. According to the polysomnographic findings, the patients were divided into those with and without REM sleep abnormalities. Abnormal REM sleep features were defined as REM sleep without atonia (RWA) and REM sleep behavior disorder (RBD). RESULTS: Eighteen (40%) of the PD patients showed either RWA (24%; 6 men, 5 women) or RBD (16%; 6 men, 1 woman). Patients with REM sleep disturbances had a significantly longer duration of the disease (8.3 vs. 3.9 years), a more severe stage of the disease (2.6 vs. 2.0 Hoehn and Yahr stage) and were treated with a higher dosage of dopaminergic drugs (L-dopa, pergolide and bromocriptin). 67% of the patients with normal REM sleep were untreated at the time of the sleep study, but only 39% of those with REM sleep abnormalities. Sleep EEG measures (sleep efficiency, sleep onset latency, sleep period time, relative amounts of sleep stages) for the second night showed no significant differences between both groups apart from a significantly lower sleep period time in PD patients with RWA/RBD. CONCLUSIONS: Abnormal REM sleep features are a frequent finding in patients with PD. The prevalence seems to increase with a longer disease duration. Therefore, a careful follow-up is necessary. A sleep architecture not different from PD patients without RWA/RBD suggests that the underlying abnormality is confined to REM sleep. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/11383385/Polysomnographic_measures_in_Parkinson's_disease:_a_comparison_between_patients_with_and_without_REM_sleep_disturbances_ DB - PRIME DP - Unbound Medicine ER -