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Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis.
Horm Metab Res. 2001 Apr; 33(4):216-20.HM

Abstract

The objective of the present paper was to assess the presence of hormonal alterations in infertile women with stage I or II endometriosis (Group III, n = 20) compared to fertile women without endometriosis (Group I, n = 14) and to fertile women with endometriosis (Group II, n = 7). Serum levels of FSH, LH, estradiol, TSH, and PRL were measured between days 1 and 5 of the early follicular phase; in the luteal phase, three serum samples were collected for progesterone measurement, and endometrial biopsies were performed. Serum estradiol levels were lower (p = 0.035) in infertile patients with endometriosis than in fertile patients without endometriosis. Six infertile patients with endometriosis presented prolactin levels above 20 ng/ml. This was not observed in the other groups. Luteal insufficiency was more frequent in infertile patients with endometriosis (78.9%) than in fertile patients with (42.9%) or without endometriosis (0%). In a multiple logistic regression analysis, only the presence of endometriosis and infertility was significantly associated with luteal insufficiency. The serum levels of LH, FSH, and TSH were not significantly different among the groups. Luteal insufficiency and altered prolactin secretion were associated with endometriosis, and could be important mechanisms causing infertility in this group of patients.

Authors+Show Affiliations

Obstetrics and Gynecology Department, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11383925

Citation

Cunha-Filho, J S., et al. "Hyperprolactinemia and Luteal Insufficiency in Infertile Patients With Mild and Minimal Endometriosis." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 33, no. 4, 2001, pp. 216-20.
Cunha-Filho JS, Gross JL, Lemos NA, et al. Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis. Horm Metab Res. 2001;33(4):216-20.
Cunha-Filho, J. S., Gross, J. L., Lemos, N. A., Brandelli, A., Castillos, M., & Passos, E. P. (2001). Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 33(4), 216-20.
Cunha-Filho JS, et al. Hyperprolactinemia and Luteal Insufficiency in Infertile Patients With Mild and Minimal Endometriosis. Horm Metab Res. 2001;33(4):216-20. PubMed PMID: 11383925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis. AU - Cunha-Filho,J S, AU - Gross,J L, AU - Lemos,N A, AU - Brandelli,A, AU - Castillos,M, AU - Passos,E P, PY - 2001/6/1/pubmed PY - 2001/10/19/medline PY - 2001/6/1/entrez SP - 216 EP - 20 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 33 IS - 4 N2 - The objective of the present paper was to assess the presence of hormonal alterations in infertile women with stage I or II endometriosis (Group III, n = 20) compared to fertile women without endometriosis (Group I, n = 14) and to fertile women with endometriosis (Group II, n = 7). Serum levels of FSH, LH, estradiol, TSH, and PRL were measured between days 1 and 5 of the early follicular phase; in the luteal phase, three serum samples were collected for progesterone measurement, and endometrial biopsies were performed. Serum estradiol levels were lower (p = 0.035) in infertile patients with endometriosis than in fertile patients without endometriosis. Six infertile patients with endometriosis presented prolactin levels above 20 ng/ml. This was not observed in the other groups. Luteal insufficiency was more frequent in infertile patients with endometriosis (78.9%) than in fertile patients with (42.9%) or without endometriosis (0%). In a multiple logistic regression analysis, only the presence of endometriosis and infertility was significantly associated with luteal insufficiency. The serum levels of LH, FSH, and TSH were not significantly different among the groups. Luteal insufficiency and altered prolactin secretion were associated with endometriosis, and could be important mechanisms causing infertility in this group of patients. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/11383925/Hyperprolactinemia_and_luteal_insufficiency_in_infertile_patients_with_mild_and_minimal_endometriosis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-14945 DB - PRIME DP - Unbound Medicine ER -