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Acute plasma volume expansion in the untrained alters the hormonal response to prolonged moderate-intensity exercise.
Horm Metab Res. 2001 Apr; 33(4):238-45.HM

Abstract

To investigate the role of an increase in plasma volume (PV), characteristically observed with short-term endurance training, on the endocrine response to prolonged moderate intensity exercise, eight untrained males (VO2 peak = 3.52 +/- 0.12 l x min(-1)) performed 90 min of cycle ergometry at approximately 60% VO2peak both before (CON) and following (PVX) PV expansion. Acute PV expansion, which was accomplished using a solution of Dextran (6%) or Pentispan (10%) (6.7 ml kg(-1)), resulted in a calculated 15.8+/-2.2% increase (p<0.05) in PV. The prolonged exercise resulted in increases (p<0.05) in plasma vasopressin (AVP), plasma rennin activity (PRA), aldosterone (ALD), atrial naturetic peptide (alpha-ANP), and the catecholamines norepinephrine (NE) and epinephrine (EPI). PVX blunted the increases (p<0.05) in AVP, PRA, ALD, NE and EPI, during the exercise itself. The concentration of alpha-ANP was also lower (p<0.05) during exercise following PVX, an effect that could be attributed to the lower resting levels. No differences in osmolality was observed between conditions. These results demonstrate that PVX alters the fluid regulatory hormonal response in untrained subjects to moderate intensity dynamic exercise in a manner similar to that observed following short-term training induced alterations in PV. The specific mechanisms responsible for these alterations remain unclear, but appear to be related directly to the increase in PV.

Authors+Show Affiliations

Dept. of Kinesiology, University of Waterloo, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11383929

Citation

Roy, B D., et al. "Acute Plasma Volume Expansion in the Untrained Alters the Hormonal Response to Prolonged Moderate-intensity Exercise." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 33, no. 4, 2001, pp. 238-45.
Roy BD, Green HJ, Grant SM, et al. Acute plasma volume expansion in the untrained alters the hormonal response to prolonged moderate-intensity exercise. Horm Metab Res. 2001;33(4):238-45.
Roy, B. D., Green, H. J., Grant, S. M., & Tarnopolsky, M. A. (2001). Acute plasma volume expansion in the untrained alters the hormonal response to prolonged moderate-intensity exercise. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 33(4), 238-45.
Roy BD, et al. Acute Plasma Volume Expansion in the Untrained Alters the Hormonal Response to Prolonged Moderate-intensity Exercise. Horm Metab Res. 2001;33(4):238-45. PubMed PMID: 11383929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute plasma volume expansion in the untrained alters the hormonal response to prolonged moderate-intensity exercise. AU - Roy,B D, AU - Green,H J, AU - Grant,S M, AU - Tarnopolsky,M A, PY - 2001/6/1/pubmed PY - 2001/10/19/medline PY - 2001/6/1/entrez SP - 238 EP - 45 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 33 IS - 4 N2 - To investigate the role of an increase in plasma volume (PV), characteristically observed with short-term endurance training, on the endocrine response to prolonged moderate intensity exercise, eight untrained males (VO2 peak = 3.52 +/- 0.12 l x min(-1)) performed 90 min of cycle ergometry at approximately 60% VO2peak both before (CON) and following (PVX) PV expansion. Acute PV expansion, which was accomplished using a solution of Dextran (6%) or Pentispan (10%) (6.7 ml kg(-1)), resulted in a calculated 15.8+/-2.2% increase (p<0.05) in PV. The prolonged exercise resulted in increases (p<0.05) in plasma vasopressin (AVP), plasma rennin activity (PRA), aldosterone (ALD), atrial naturetic peptide (alpha-ANP), and the catecholamines norepinephrine (NE) and epinephrine (EPI). PVX blunted the increases (p<0.05) in AVP, PRA, ALD, NE and EPI, during the exercise itself. The concentration of alpha-ANP was also lower (p<0.05) during exercise following PVX, an effect that could be attributed to the lower resting levels. No differences in osmolality was observed between conditions. These results demonstrate that PVX alters the fluid regulatory hormonal response in untrained subjects to moderate intensity dynamic exercise in a manner similar to that observed following short-term training induced alterations in PV. The specific mechanisms responsible for these alterations remain unclear, but appear to be related directly to the increase in PV. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/11383929/Acute_plasma_volume_expansion_in_the_untrained_alters_the_hormonal_response_to_prolonged_moderate_intensity_exercise_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-14943 DB - PRIME DP - Unbound Medicine ER -