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Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori.
Am J Trop Med Hyg. 2000 Sep-Oct; 63(3-4):189-91.AJ

Abstract

Helicobacter pylori and hepatitis A virus (HAV) are documented to share common transmission routes including fecal-oral. This study examined the association between seropositivity of antibodies against H. pylori (anti-HP) and HAV (anti-HAV) via a community-based survey of 40 randomly selected kindergartens in 10 urban and 10 rural areas. Serum samples from 2,047 healthy preschool children and 104 teachers were screened for anti-HP by enzyme-linked immunosorbent assay, and for anti-HAV by microparticle enzyme immunoassay. In children, a low prevalence of anti-HAV (0.44%) was found, in contrast to a high prevalence in their teachers (78.8%); anti-HP seroprevalence was 6.4% for children and 30.8% for teachers. Anti-HAV and anti-HP seropositivities were significantly associated in teachers after adjustment for age, sex, and residential area through multiple logistic regression analysis (multivariate-adjusted odds ratio = 7.3; 95% confidence interval [CI] = 1.4-36.8, P < 0.001). Our findings suggest that HAV and H. pylori may have shared transmission routes in central Taiwan 15 years or more ago, but not any recently.

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Authors+Show Affiliations

Lin DB
School of Medical Technology, and Graduate Institute of Medicine, Department of Anatomy, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China.
Tsai TP
No affiliation info available
Yang CC
No affiliation info available
Wang HM
No affiliation info available
Nieh WT
No affiliation info available
Ling UP
No affiliation info available
Changlai SP
No affiliation info available
You SL
No affiliation info available
Ho MS
No affiliation info available
Chen CJ
No affiliation info available

MeSH

AdultAntibodies, BacterialAntibodies, ViralChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleHelicobacter InfectionsHelicobacter pyloriHepatitis AHepatovirusHumansIncidenceMaleRural HealthSeroepidemiologic StudiesTaiwanUrban Health

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11388513

Citation

Lin, D B., et al. "Association Between Seropositivity of Antibodies Against Hepatitis a Virus and Helicobacter Pylori." The American Journal of Tropical Medicine and Hygiene, vol. 63, no. 3-4, 2000, pp. 189-91.
Lin DB, Tsai TP, Yang CC, et al. Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori. Am J Trop Med Hyg. 2000;63(3-4):189-91.
Lin, D. B., Tsai, T. P., Yang, C. C., Wang, H. M., Nieh, W. T., Ling, U. P., Changlai, S. P., You, S. L., Ho, M. S., & Chen, C. J. (2000). Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori. The American Journal of Tropical Medicine and Hygiene, 63(3-4), 189-91.
Lin DB, et al. Association Between Seropositivity of Antibodies Against Hepatitis a Virus and Helicobacter Pylori. Am J Trop Med Hyg. 2000 Sep-Oct;63(3-4):189-91. PubMed PMID: 11388513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori. AU - Lin,D B, AU - Tsai,T P, AU - Yang,C C, AU - Wang,H M, AU - Nieh,W T, AU - Ling,U P, AU - Changlai,S P, AU - You,S L, AU - Ho,M S, AU - Chen,C J, PY - 2001/6/5/pubmed PY - 2001/6/15/medline PY - 2001/6/5/entrez SP - 189 EP - 91 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 63 IS - 3-4 N2 - Helicobacter pylori and hepatitis A virus (HAV) are documented to share common transmission routes including fecal-oral. This study examined the association between seropositivity of antibodies against H. pylori (anti-HP) and HAV (anti-HAV) via a community-based survey of 40 randomly selected kindergartens in 10 urban and 10 rural areas. Serum samples from 2,047 healthy preschool children and 104 teachers were screened for anti-HP by enzyme-linked immunosorbent assay, and for anti-HAV by microparticle enzyme immunoassay. In children, a low prevalence of anti-HAV (0.44%) was found, in contrast to a high prevalence in their teachers (78.8%); anti-HP seroprevalence was 6.4% for children and 30.8% for teachers. Anti-HAV and anti-HP seropositivities were significantly associated in teachers after adjustment for age, sex, and residential area through multiple logistic regression analysis (multivariate-adjusted odds ratio = 7.3; 95% confidence interval [CI] = 1.4-36.8, P < 0.001). Our findings suggest that HAV and H. pylori may have shared transmission routes in central Taiwan 15 years or more ago, but not any recently. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/11388513/Association_between_seropositivity_of_antibodies_against_hepatitis_a_virus_and_Helicobacter_pylori_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.2000.63.189 DB - PRIME DP - Unbound Medicine ER -